{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:18:27Z","timestamp":1791875907322,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Independent Research Fund Denmark","award":["DFF-4092\u20130004"],"award-info":[{"award-number":["DFF-4092\u20130004"]}]},{"name":"Independent Research Fund Denmark","award":["DFF-6110\u201300166"],"award-info":[{"award-number":["DFF-6110\u201300166"]}]},{"name":"The Novo Nordisk Foundation","award":["NNF15OC0017586"],"award-info":[{"award-number":["NNF15OC0017586"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL134328"],"award-info":[{"award-number":["RO1 HL134328"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1074\/mcp.ra119.001878","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T21:54:27Z","timestamp":1586901267000},"page":"1132-1144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation"],"prefix":"10.1016","volume":"19","author":[{"given":"Nora","family":"Linscheid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi Camilla","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Dalgaard","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gregers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Hastrup","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Salling","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-4938","authenticated-orcid":false,"given":"Jesper Velgaard","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Delmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1612-6041","authenticated-orcid":false,"given":"Alicia","family":"Lundby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.RA119.001878_bib1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/s12864-015-1686-y","article-title":"The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling","volume":"16","author":"Lindskog","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1074\/mcp.RA119.001878_bib2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s00109-004-0527-2","article-title":"Global gene expression in human myocardium\u2014oligonucleotide microarray analysis of regional diversity and transcriptional regulation in heart failure","volume":"82","author":"K\u00e4\u00e4b","year":"2004","journal-title":"J. Mol. Med"},{"key":"10.1074\/mcp.RA119.001878_bib3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature13319","article-title":"Mass-spectrometry-based draft of the human proteome","volume":"509","author":"Wilhelm","year":"2014","journal-title":"Nature"},{"key":"10.1074\/mcp.RA119.001878_bib4","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature13302","article-title":"A draft map of the human proteome","volume":"509","author":"Kim","year":"2014","journal-title":"Nature"},{"key":"10.1074\/mcp.RA119.001878_bib5","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1039\/c004495d","article-title":"Proteome-wide protein concentrations in the human heart","volume":"6","author":"Aye","year":"2010","journal-title":"Mol. BioSystems"},{"key":"10.1074\/mcp.RA119.001878_bib6","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1021\/pr5007685","article-title":"Proteomic analysis of human fetal atria and ventricle","volume":"13","author":"Lu","year":"2014","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA119.001878_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01747-2","article-title":"Region and cell-type resolved quantitative proteomic map of the human heart","volume":"8","author":"Doll","year":"2017","journal-title":"Nat. Communications"},{"key":"10.1074\/mcp.RA119.001878_bib8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.RA119.001878_bib9","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1074\/mcp.RA119.001878_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cels.2017.05.009","article-title":"An optimized shotgun strategy for the rapid generation of comprehensive human proteomes","volume":"4","author":"Bekker-Jensen","year":"2017","journal-title":"Cell Systems"},{"key":"10.1074\/mcp.RA119.001878_bib11","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat. Protocols"},{"key":"10.1074\/mcp.RA119.001878_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1074\/mcp.RA119.001878_bib13","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.RA119.001878_bib14","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1021\/pr500893m","article-title":"Off-line high-pH reversed-phase fractionation for in-depth phosphoproteomics","volume":"13","author":"Batth","year":"2014","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA119.001878_bib15","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ng.3383","article-title":"Genetic association analyses highlight biological pathways underlying mitral valve prolapse","volume":"47","author":"Dina","year":"2015","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.RA119.001878_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanh\u00e4usser","year":"2011","journal-title":"Nature"},{"key":"10.1074\/mcp.RA119.001878_bib17","article-title":"Genome-wide genetic data on \u223c500,000 UK Biobank participants","author":"Bycroft","year":"2017","journal-title":"bioRxiv"},{"key":"10.1074\/mcp.RA119.001878_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tcm.2003.09.005","article-title":"Molecular Regulation of Cardiac Chamber-Specific Gene Expression","volume":"14","author":"Small","year":"2004","journal-title":"Trends Cardiovascular Med"},{"key":"10.1074\/mcp.RA119.001878_bib19","doi-asserted-by":"crossref","first-page":"23295","DOI":"10.1016\/S0021-9258(18)50090-9","article-title":"Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development","volume":"267","author":"Hailstones","year":"1992","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.RA119.001878_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-1119(99)00365-0","article-title":"Functional and structural diversity of the human Dickkopf gene family","volume":"238","author":"Krupnik","year":"1999","journal-title":"Gene"},{"key":"10.1074\/mcp.RA119.001878_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0925-4773(99)00138-0","article-title":"Dickkopf genes are co-ordinately expressed in mesodermal lineages","volume":"87","author":"Monaghan","year":"1999","journal-title":"Mech. Dev"},{"key":"10.1074\/mcp.RA119.001878_bib22","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCULATIONAHA.117.028585","article-title":"Experimental modeling supports a role for MyBP-HL as a novel myofilament component in arrhythmia and dilated cardiomyopathy","volume":"136","author":"Barefield","year":"2017","journal-title":"Circulation"},{"key":"10.1074\/mcp.RA119.001878_bib23","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1074\/mcp.RA119.001878_bib24","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/1471-2105-12-436","article-title":"clusterMaker: a multi-algorithm clustering plugin for Cytoscape","volume":"12","author":"Morris","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.RA119.001878_bib25","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein\u2013protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.RA119.001878_bib26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.RA119.001878_bib27","doi-asserted-by":"crossref","first-page":"e26389","DOI":"10.1371\/journal.pone.0026389","article-title":"Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue","volume":"6","author":"Kahr","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.RA119.001878_bib28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/CIRCGENETICS.112.962894","article-title":"Genetic basis of familial valvular heart disease","volume":"5","author":"Padang","year":"2012","journal-title":"Circ. Cardiovasc. Genet"},{"key":"10.1074\/mcp.RA119.001878_bib29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1152\/physiolgenomics.00137.2011","article-title":"Comparison of human cardiac gene expression profiles in paired samples of right atrium and left ventricle collected in vivo","volume":"44","author":"Asp","year":"2012","journal-title":"Physiol. Genomics"},{"key":"10.1074\/mcp.RA119.001878_bib30","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1096\/fj.11-190728","article-title":"Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload","volume":"26","author":"Frolova","year":"2012","journal-title":"FASEB J"},{"key":"10.1074\/mcp.RA119.001878_bib31","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/CIRCRESAHA.111.256743","article-title":"Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle","volume":"109","author":"Cingolani","year":"2011","journal-title":"Circ. Res"},{"key":"10.1074\/mcp.RA119.001878_bib32","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.RES.0000165480.82737.33","article-title":"Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature","volume":"96","author":"Barth","year":"2005","journal-title":"Circ. Res"},{"key":"10.1074\/mcp.RA119.001878_bib33","doi-asserted-by":"crossref","first-page":"354ra115","DOI":"10.1126\/scitranslmed.aaf4891","article-title":"Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm","volume":"8","author":"Nadadur","year":"2016","journal-title":"Sci. Transl. Med"},{"key":"10.1074\/mcp.RA119.001878_bib34","article-title":"Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies","author":"Zhou","year":"2017","journal-title":"bioRxiv"},{"key":"10.1074\/mcp.RA119.001878_bib35","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nmeth.2997","article-title":"Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics","volume":"11","author":"Lundby","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.RA119.001878_bib36","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat. Rev. Cardiol"},{"key":"10.1074\/mcp.RA119.001878_bib37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00380-013-0400-8","article-title":"Pentraxin 3 is a local inflammatory marker in atrial fibrillation","volume":"29","author":"Soeki","year":"2014","journal-title":"Heart Vessels"},{"key":"10.1074\/mcp.RA119.001878_bib38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/01.HYP.0000025443.61926.12","article-title":"Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts","volume":"40","author":"Akiyama-Uchida","year":"2002","journal-title":"Hypertension"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762034977X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S153594762034977X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.RA119.001878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:05:04Z","timestamp":1761527104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S153594762034977X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S153594762034977X"],"URL":"https:\/\/doi.org\/10.1074\/mcp.ra119.001878","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.RA119.001878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Linscheid et al.","name":"copyright","label":"Copyright"}]}}