{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T09:10:30Z","timestamp":1771146630724,"version":"3.50.1"},"reference-count":80,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR071359"],"award-info":[{"award-number":["R01 AR071359"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DP2 AT009833"],"award-info":[{"award-number":["DP2 AT009833"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1074\/mcp.ra120.001998","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T14:56:21Z","timestamp":1588863381000},"page":"1220-1235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8501-1822","authenticated-orcid":false,"given":"Alexander R.","family":"Ocken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline M.","family":"Ku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara L.","family":"Kinzer-Ursem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-6307","authenticated-orcid":false,"given":"Sarah","family":"Calve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.RA120.001998_bib1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.matbio.2012.05.002","article-title":"A biomechanical role for perlecan in the pericellular matrix of articular cartilage","volume":"31","author":"Wilusz","year":"2012","journal-title":"Matrix Biol"},{"key":"10.1074\/mcp.RA120.001998_bib2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1196\/annals.1346.011","article-title":"The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage","volume":"1068","author":"Guilak","year":"2006","journal-title":"Ann. N.Y. Acad. Sci"},{"key":"10.1074\/mcp.RA120.001998_bib3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1083\/jcb.145.5.1103","article-title":"Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro","volume":"145","author":"French","year":"1999","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.RA120.001998_bib4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.joca.2007.01.021","article-title":"FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer","volume":"15","author":"Vincent","year":"2007","journal-title":"Osteoarthr. Cartil"},{"key":"10.1074\/mcp.RA120.001998_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.matbio.2013.08.004","article-title":"Border patrol: Insights into the unique role of perlecan\/heparan sulfate proteoglycan 2 at cell and tissue borders","volume":"34","author":"Farach-Carson","year":"2014","journal-title":"Matrix Biol"},{"key":"10.1074\/mcp.RA120.001998_bib6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/86941","article-title":"Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene","volume":"27","author":"Arikawa-Hirasawa","year":"2001","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.RA120.001998_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/82638","article-title":"Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia)","volume":"26","author":"Nicole","year":"2000","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.RA120.001998_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/hmg\/ddl484","article-title":"Reduced perlecan in mice results in chondrodysplasia resembling Schwartz\u2013Jampel syndrome","volume":"16","author":"Rodgers","year":"2007","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/mcp.RA120.001998_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/SAP.0b013e3181fac1ec","article-title":"Multidisciplinary approach to the treatment of a patient with chondrodystrophic myotonia (Schwartz-Jampel vel Aberfeld Syndrome)","volume":"67","author":"Nessler","year":"2011","journal-title":"Ann. Plast. Surg"},{"key":"10.1074\/mcp.RA120.001998_bib10","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1083\/jcb.147.5.1109","article-title":"Perlecan maintains the integrity of cartilage and some basement membranes","volume":"147","author":"Costell","year":"1999","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.RA120.001998_bib11","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1093\/hmg\/ddn213","article-title":"Evidence of a dosage effect and a physiological endplate acetylcholinesterase deficiency in the first mouse models mimicking Schwartz\u2013Jampel syndrome neuromyotonia","volume":"17","author":"Stum","year":"2008","journal-title":"Hum. Mol. Genet"},{"key":"10.1074\/mcp.RA120.001998_bib12","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/jcb.27521","article-title":"Perlecan\/HSPG2: Signaling role of domain IV in chondrocyte clustering with implications for Schwartz-Jampel Syndrome","volume":"120","author":"Martinez","year":"2019","journal-title":"J. Cell. Biochem"},{"key":"10.1074\/mcp.RA120.001998_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2016.07.008","article-title":"Signaling pathways regulating cartilage growth plate formation and activity","volume":"62","author":"Samsa","year":"2017","journal-title":"Semin. Cell Dev. Biol"},{"key":"10.1074\/mcp.RA120.001998_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.matbio.2016.09.003","article-title":"A current view of perlecan in physiology and pathology: A mosaic of functions","volume":"57\u201358","author":"Gubbiotti","year":"2017","journal-title":"Matrix Biol"},{"key":"10.1074\/mcp.RA120.001998_bib15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ydbio.2016.08.029","article-title":"Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage","volume":"418","author":"Xu","year":"2016","journal-title":"Dev. Biol"},{"key":"10.1074\/mcp.RA120.001998_bib16","first-page":"3525","article-title":"Collagen VI at a glance","volume":"128","author":"Cescon","year":"2015","journal-title":"J. Cell Sci"},{"key":"10.1074\/mcp.RA120.001998_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-matsci-062910-100431","article-title":"Nanomechanics of the cartilage extracellular matrix","volume":"41","author":"Han","year":"2011","journal-title":"Annu. Rev. Mater. Res"},{"key":"10.1074\/mcp.RA120.001998_bib18","doi-asserted-by":"crossref","first-page":"81002","DOI":"10.1115\/1.4043208","article-title":"Computational modeling of developing cartilage using experimentally derived geometries and compressive moduli","volume":"141","author":"Lycke","year":"2019","journal-title":"J. Biomech. Eng"},{"key":"10.1074\/mcp.RA120.001998_bib19","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1242\/dev.125.6.1067","article-title":"Regulation of growth region cartilage proliferation and differentiation by perichondrium","volume":"125","author":"Long","year":"1998","journal-title":"Development"},{"key":"10.1074\/mcp.RA120.001998_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.matbio.2012.02.006","article-title":"Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation","volume":"31","author":"Ishijima","year":"2012","journal-title":"Matrix Biol"},{"key":"10.1074\/mcp.RA120.001998_bib21","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014647","article-title":"The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices","volume":"11","author":"Naba","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.RA120.001998_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/15537","article-title":"Perlecan is essential for cartilage and cephalic development","volume":"23","author":"Arikawa-Hirasawa","year":"1999","journal-title":"Nat. Genet"},{"key":"10.1074\/mcp.RA120.001998_bib23","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"10.1074\/mcp.RA120.001998_bib24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.RA120.001998_bib25","first-page":"127","article-title":"Molecular and biochemical assays of cartilage components","volume":"101","author":"Hoemann","year":"2004","journal-title":"Methods Mol. Med"},{"key":"10.1074\/mcp.RA120.001998_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1021\/acs.jproteome.5b00946","article-title":"Elucidating the molecular composition of cartilage by proteomics","volume":"15","author":"Hsueh","year":"2016","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.001998_bib27","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.RA120.001998_bib28","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/acs.jproteome.7b00191","article-title":"Characterization of the extracellular matrix of normal and diseased tissues using proteomics","volume":"16","author":"Naba","year":"2017","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.001998_bib29","article-title":"Hspg2C1532YNeo DBA distal humeral cartilage proteomic comparison dataset","author":"Ocken","year":"2019","journal-title":"MassIVE"},{"key":"10.1074\/mcp.RA120.001998_bib30","doi-asserted-by":"crossref","first-page":"W83","DOI":"10.1093\/nar\/gkw199","article-title":"g:Profiler\u2014a web server for functional interpretation of gene lists. (2016 update)","volume":"44","author":"Reimand","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.RA120.001998_bib31","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/nprot.2013.086","article-title":"Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization","volume":"8","author":"Starborg","year":"2013","journal-title":"Nat. Protoc"},{"key":"10.1074\/mcp.RA120.001998_bib32","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1021\/acs.jproteome.5b01115","article-title":"Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation","volume":"15","author":"Wilson","year":"2016","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.001998_bib33","article-title":"Hspg2C1532YNeo DBA distal humeral cartilage secretome proteomic comparison","author":"Ocken","year":"2019","journal-title":"MassIVE"},{"key":"10.1074\/mcp.RA120.001998_bib34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1115\/1.1688772","article-title":"Determination of Poisson's ratio of articular cartilage by indentation using different-sized indenters","volume":"126","author":"Jin","year":"2004","journal-title":"J. Biomech. Eng"},{"key":"10.1074\/mcp.RA120.001998_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jbiomech.2004.11.006","article-title":"Determination of the Poisson's ratio of the cell: Recovery properties of chondrocytes after release from complete micropipette aspiration","volume":"39","author":"Trickey","year":"2006","journal-title":"J. Biomech"},{"key":"10.1074\/mcp.RA120.001998_bib36","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/pr501223t","article-title":"Summarization vs peptide-based models in label-free quantitative proteomics: performance, pitfalls, and data analysis guidelines","volume":"14","author":"Goeminne","year":"2015","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.001998_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/biomet\/93.3.491","article-title":"Adaptive linear step-up procedures that control the false discovery rate","volume":"93","author":"Benjamini","year":"2006","journal-title":"Biometrika"},{"key":"10.1074\/mcp.RA120.001998_bib38","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1046\/j.1432-1327.1999.00127.x","article-title":"Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin","volume":"259","author":"Hopf","year":"1999","journal-title":"Eur. J. Biochem"},{"key":"10.1074\/mcp.RA120.001998_bib39","first-page":"511","article-title":"Perlecan: An important component of the cartilage pericellular matrix","volume":"2","author":"Gomes","year":"2002","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"10.1074\/mcp.RA120.001998_bib40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/excr.2002.5611","article-title":"Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens","volume":"279","author":"Salmivirta","year":"2002","journal-title":"Exp. Cell Res"},{"key":"10.1074\/mcp.RA120.001998_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1042\/BCJ20180695","article-title":"Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc","volume":"476","author":"Shu","year":"2019","journal-title":"Biochem. J"},{"key":"10.1074\/mcp.RA120.001998_bib42","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.RA120.001998_bib43","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12195-019-00592-1","article-title":"Dynamics of non-canonical amino acid-labeled intra- and extracellular proteins in the developing mouse","volume":"12","author":"Saleh","year":"2019","journal-title":"Cell Mol. Bioeng"},{"key":"10.1074\/mcp.RA120.001998_bib44","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"Mi","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.RA120.001998_bib45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-5793(78)80468-2","article-title":"Predominance of type I collagen at the surface of avian articular cartilage","volume":"85","author":"Eyre","year":"1978","journal-title":"FEBS Lett"},{"key":"10.1074\/mcp.RA120.001998_bib46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0009-9120(96)00003-6","article-title":"A simplified method for the analysis of hydroxyproline in biological tissues","volume":"29","author":"Kesava Reddy","year":"1996","journal-title":"Clin. Biochem"},{"key":"10.1074\/mcp.RA120.001998_bib47","doi-asserted-by":"crossref","first-page":"11402","DOI":"10.1021\/ja047069h","article-title":"Imino acids and collagen triple helix stability: characterization of collagen-like polypeptides containing hyp-hyp-gly sequence repeats","volume":"126","author":"Berisio","year":"2004","journal-title":"J. Am. Chem. Soc"},{"key":"10.1074\/mcp.RA120.001998_bib48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S8756-3282(97)00279-2","article-title":"Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance","volume":"2","author":"Knott","year":"1998","journal-title":"Bone"},{"key":"10.1074\/mcp.RA120.001998_bib49","doi-asserted-by":"crossref","first-page":"33127","DOI":"10.1074\/jbc.M607892200","article-title":"Chondroitin sulfate perlecan enhances collagen fibril formation: Implications for perlecan chondrodysplasias","volume":"281","author":"Kvist","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.RA120.001998_bib50","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.addr.2003.08.002","article-title":"Collagens-structure, function, and biosynthesis","volume":"55","author":"Gelse","year":"2003","journal-title":"Adv. Drug Deliv. Rev"},{"key":"10.1074\/mcp.RA120.001998_bib51","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1053\/joca.1999.0299","article-title":"Glucosamine HCl reduces equine articular cartilage degradation in explant culture","volume":"8","author":"Fenton","year":"2000","journal-title":"Osteoarthr. Cartil"},{"key":"10.1074\/mcp.RA120.001998_bib52","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/1947603510383855","article-title":"Characterization of an ex vivo femoral head model assessed by markers of bone and cartilage turnover","volume":"2","author":"Madsen","year":"2010","journal-title":"Cartilage"},{"key":"10.1074\/mcp.RA120.001998_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03008207.2019.1698556","article-title":"Ontogeny informs regeneration: explant models to investigate the role of the extracellular matrix in cartilage tissue assembly and development","volume":"61","author":"McCreery","year":"2020","journal-title":"Connect. Tissue Res"},{"key":"10.1074\/mcp.RA120.001998_bib54","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1432-0436.1994.5530213.x","article-title":"Distribution of mRNA coding for Alpha-2-macroglobulin, the murinoglobulins, the Alpha-2-macroglobulin receptor and the Alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues","volume":"55","author":"Lorent","year":"1994","journal-title":"Differentiation"},{"key":"10.1074\/mcp.RA120.001998_bib55","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1177\/0363546517712506","article-title":"In vivo tibial cartilage strains in regions of cartilage-to-cartilage contact and cartilage-to-meniscus contact in response to walking","volume":"45","author":"Liu","year":"2017","journal-title":"Am. J. Sports Med"},{"key":"10.1074\/mcp.RA120.001998_bib56","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fbioe.2017.00076","article-title":"Dynamic mechanical compression of chondrocytes for tissue engineering: A critical review","volume":"5","author":"Anderson","year":"2017","journal-title":"Front. Bioeng. Biotechnol"},{"key":"10.1074\/mcp.RA120.001998_bib57","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1074\/mcp.M111.014159","article-title":"Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development","volume":"11","author":"Wilson","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.RA120.001998_bib58","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.joca.2007.05.008","article-title":"Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: Serpins as cartilage-relevant differentiation markers","volume":"16","author":"Boeuf","year":"2008","journal-title":"Osteoarthr. Cartil"},{"key":"10.1074\/mcp.RA120.001998_bib59","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.3390\/ijms18112481","article-title":"Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis","volume":"18","author":"Iacobini","year":"2017","journal-title":"Int. J. Mol. Sci"},{"key":"10.1074\/mcp.RA120.001998_bib60","doi-asserted-by":"crossref","first-page":"10370","DOI":"10.1074\/jbc.275.14.10370","article-title":"Collagen XI nucleates self-assembly and limits lateral growth of cartilage fibrils","volume":"275","author":"Blaschke","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.RA120.001998_bib61","series-title":"Rheumatology","first-page":"33","article-title":"Articular cartilage","author":"Heineg\u00e5rd","year":"2015"},{"key":"10.1074\/mcp.RA120.001998_bib62","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1074\/jbc.M114.593541","article-title":"The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation","volume":"290","author":"Tillgren","year":"2015","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.RA120.001998_bib63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bone.2013.03.007","article-title":"Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2","volume":"55","author":"Ishida","year":"2013","journal-title":"Bone"},{"key":"10.1074\/mcp.RA120.001998_bib64","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.1128\/MCB.25.15.6846-6856.2005","article-title":"Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice","volume":"25","author":"Bader","year":"2005","journal-title":"Mol. Cell. Biol"},{"key":"10.1074\/mcp.RA120.001998_bib65","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0945-053X(02)00070-7","article-title":"Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice","volume":"21","author":"Miosge","year":"2002","journal-title":"Matrix Biol"},{"key":"10.1074\/mcp.RA120.001998_bib66","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.bbrc.2015.05.053","article-title":"Osteomodulin regulates diameter and alters shape of collagen fibrils","volume":"463","author":"Tashima","year":"2015","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1074\/mcp.RA120.001998_bib67","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1083\/jcb.200106040","article-title":"Coordinated expression of matrix Gla protein is required during endochondral ossification for chondrocyte survival","volume":"154","author":"Newman","year":"2001","journal-title":"J. Cell Biol"},{"key":"10.1074\/mcp.RA120.001998_bib68","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/art.39034","article-title":"Type VI collagen regulates pericellular matrix properties, chondrocyte swelling, and mechanotransduction in mouse articular cartilage","volume":"67","author":"Zelenski","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1074\/mcp.RA120.001998_bib69","doi-asserted-by":"crossref","first-page":"e29422","DOI":"10.1371\/journal.pone.0029422","article-title":"Collagen XXVII organises the pericellular matrix in the growth plate","volume":"6","author":"Plumb","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.RA120.001998_bib70","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1074\/jbc.M003820200","article-title":"Cathepsin B activity regulation: heparin-like glycosaminoglycans protect human cathepsin B from alkaline pH-induced inactivation","volume":"276","author":"Almeida","year":"2001","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.RA120.001998_bib71","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbapap.2011.10.002","article-title":"Cysteine cathepsins: From structure, function and regulation to new frontiers","volume":"1824","author":"Turk","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/mcp.RA120.001998_bib72","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1016\/j.celrep.2018.02.066","article-title":"TGF-beta regulates cathepsin activation during normal and pathogenic development","volume":"22","author":"Flanagan-Steet","year":"2018","journal-title":"Cell Rep"},{"key":"10.1074\/mcp.RA120.001998_bib73","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/jor.22838","article-title":"Type III collagen modulates fracture callus bone formation and early remodeling","volume":"33","author":"Miedel","year":"2015","journal-title":"J. Orthop. Res"},{"key":"10.1074\/mcp.RA120.001998_bib74","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1023\/A:1003954104290","article-title":"The expression of the fibrillar collagen genes during fracture healing: Heterogeneity of the matrices and differentiation of the osteoprogenitor cells","volume":"31","author":"Bland","year":"1999","journal-title":"Histochem. J"},{"key":"10.1074\/mcp.RA120.001998_bib75","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2009.08.013","article-title":"Deficiency of tenascin-C delays articular cartilage repair in mice","volume":"18","author":"Okamura","year":"2010","journal-title":"Osteoarthr. Cartil"},{"key":"10.1074\/mcp.RA120.001998_bib76","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12891-015-0682-3","article-title":"Expression and pathological effects of periostin in human osteoarthritis cartilage","volume":"16","author":"Chijimatsu","year":"2015","journal-title":"BMC Musculoskelet. Disord"},{"key":"10.1074\/mcp.RA120.001998_bib77","doi-asserted-by":"crossref","first-page":"24272","DOI":"10.1038\/srep24272","article-title":"Mapping the nonreciprocal micromechanics of individual cells and the surrounding matrix within living tissues","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep"},{"key":"10.1074\/mcp.RA120.001998_bib78","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s12195-009-0081-7","article-title":"Pericellular matrix mechanics in the anulus fibrosus predicted by a three-dimensional finite element model and in situ morphology","volume":"2","author":"Cao","year":"2009","journal-title":"Cell Mol. Bioeng"},{"key":"10.1074\/mcp.RA120.001998_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10237-010-0214-x","article-title":"Three-dimensional finite element modeling of pericellular matrix and cell mechanics in the nucleus pulposus of the intervertebral disk based on in situ morphology","volume":"10","author":"Cao","year":"2011","journal-title":"Biomech. Model Mechanobiol"},{"key":"10.1074\/mcp.RA120.001998_bib80","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1016\/j.jbiomech.2014.05.001","article-title":"A biphasic multiscale study of the mechanical microenvironment of chondrocytes within articular cartilage under unconfined compression","volume":"47","author":"Guo","year":"2014","journal-title":"J. Biomech"}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620349835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620349835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.RA120.001998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:04:49Z","timestamp":1761527089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620349835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":80,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1535947620349835"],"URL":"https:\/\/doi.org\/10.1074\/mcp.ra120.001998","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.RA120.001998","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Ocken et al.","name":"copyright","label":"Copyright"}]}}