{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:52:09Z","timestamp":1773870729272,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2131\/15"],"award-info":[{"award-number":["2131\/15"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","award":["20181134"],"award-info":[{"award-number":["20181134"]}],"id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["I-1444-201.2\/2017"],"award-info":[{"award-number":["I-1444-201.2\/2017"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001736","name":"German-Israeli Foundation for Scientific Research and Development","doi-asserted-by":"publisher","award":["I-1444-201.2\/2017"],"award-info":[{"award-number":["I-1444-201.2\/2017"]}],"id":[{"id":"10.13039\/501100001736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1074\/mcp.ra120.002152","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T15:52:25Z","timestamp":1594223545000},"page":"1619-1631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors"],"prefix":"10.1016","volume":"19","author":[{"given":"Elez D.","family":"Vainer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Kania-Almog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghadeer","family":"Zatara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishai","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8828-8138","authenticated-orcid":false,"given":"Gilad W.","family":"Vainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.RA120.002152_bib1","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1021\/acs.jproteome.5b00523","article-title":"Absolute proteome analysis of colorectal mucosa, adenoma, and cancer reveals drastic changes in fatty acid metabolism and plasma membrane transporters","volume":"14","author":"Wi\u015bniewski","year":"2015","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.002152_bib2","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1021\/pr100234w","article-title":"Proteome, phosphoproteome, and N-glycoproteome are quantitatively preserved in formalin-fixed paraffin-embedded tissue and analyzable by high-resolution mass spectrometry","volume":"9","author":"Ostasiewicz","year":"2010","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.002152_bib3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/14789450.2019.1615452","article-title":"Update on proteomic studies of formalin-fixed paraffin-embedded tissues","volume":"16","author":"Giusti","year":"2019","journal-title":"Expert Rev. Proteomics"},{"key":"10.1074\/mcp.RA120.002152_bib4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.5858\/134.6.907","article-title":"American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer","volume":"134","author":"Hammond","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"10.1074\/mcp.RA120.002152_bib5","doi-asserted-by":"crossref","first-page":"e16353","DOI":"10.1371\/journal.pone.0016353","article-title":"Successful protein extraction from over-fixed and long-term stored formalin-fixed tissues","volume":"6","author":"Wolff","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.RA120.002152_bib6","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1074\/mcp.RA120.002152_bib7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Cancer Genome Atlas","year":"2012","journal-title":"Nature"},{"key":"10.1074\/mcp.RA120.002152_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.critrevonc.2017.05.006","article-title":"The current value of determining the mismatch repair status of colorectal cancer: A rationale for routine testing","volume":"116","author":"Ryan","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol"},{"key":"10.1074\/mcp.RA120.002152_bib9","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1074\/mcp.RA120.002152_bib10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejca.2017.07.026","article-title":"Hypermutated tumours in the era of immunotherapy: The paradigm of personalised medicine","volume":"84","author":"Nebot-Bral","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1074\/mcp.RA120.002152_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1158\/2159-8290.CD-14-0863","article-title":"The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints","volume":"5","author":"Llosa","year":"2015","journal-title":"Cancer Discov"},{"key":"10.1074\/mcp.RA120.002152_bib12","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"10.1074\/mcp.RA120.002152_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5582\/bst.2016.01250","article-title":"Steering of carcinoma progression by the YIN\/YANG interaction of STAT1\/STAT3","volume":"11","author":"Friedrich","year":"2017","journal-title":"Biosci. Trends"},{"key":"10.1074\/mcp.RA120.002152_bib14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/gut.2009.194472","article-title":"Intratumoral T cell infiltration, MHC class I and STAT1 as biomarkers of good prognosis in colorectal cancer","volume":"59","author":"Simpson","year":"2010","journal-title":"Gut"},{"key":"10.1074\/mcp.RA120.002152_bib15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/bjc.2013.274","article-title":"Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma","volume":"109","author":"Gordziel","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"Suppl 3","key":"10.1074\/mcp.RA120.002152_bib16","doi-asserted-by":"crossref","first-page":"S1548","DOI":"10.1245\/s10434-015-4485-4","article-title":"Expressional STAT3\/STAT5 ratio is an independent prognostic marker in colon carcinoma","volume":"22","author":"Klupp","year":"2015","journal-title":"Ann. Surg. Oncol"},{"key":"10.1074\/mcp.RA120.002152_bib17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1593\/neo.04571","article-title":"Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth","volume":"7","author":"Corvinus","year":"2005","journal-title":"Neoplasia"},{"key":"10.1074\/mcp.RA120.002152_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1593\/neo.06820","article-title":"Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction","volume":"9","author":"Tsareva","year":"2007","journal-title":"Neoplasia"},{"key":"10.1074\/mcp.RA120.002152_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ccr.2009.01.001","article-title":"IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer","volume":"15","author":"Grivennikov","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1074\/mcp.RA120.002152_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/j.gastro.2013.03.052","article-title":"The gastrointestinal tumor microenvironment","volume":"145","author":"Quante","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1074\/mcp.RA120.002152_bib21","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1053\/j.gastro.2009.11.049","article-title":"Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice","volume":"138","author":"Musteanu","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1074\/mcp.RA120.002152_bib22","first-page":"50589","article-title":"Proteomic sample preparation from formalin fixed and paraffin embedded tissue","volume":"2","author":"Wisniewski","year":"2013","journal-title":"J Vis Exp"},{"key":"10.1074\/mcp.RA120.002152_bib23","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1021\/pr200019m","article-title":"High recovery FASP applied to the proteomic analysis of microdissected formalin fixed paraffin embedded cancer tissues retrieves known colon cancer markers","volume":"10","author":"Wi\u015bniewski","year":"2011","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.002152_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1074\/mcp.RA120.002152_bib25","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol"},{"key":"10.1074\/mcp.RA120.002152_bib26","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.002152_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/prca.201200031","article-title":"Complete solubilization of formalin-fixed, paraffin-embedded tissue may improve proteomic studies","volume":"7","author":"Shi","year":"2013","journal-title":"Proteomics. Clin. Appl"},{"key":"10.1074\/mcp.RA120.002152_bib28","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1158\/2326-6066.CIR-18-0683","article-title":"Intrinsic resistance to immune checkpoint blockade in a mismatch repair-deficient colorectal cancer","volume":"7","author":"Gurjao","year":"2019","journal-title":"Cancer Immunol. Res"},{"key":"10.1074\/mcp.RA120.002152_bib29","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11864-018-0566-5","article-title":"Harnessing the immune system in pancreatic cancer","volume":"19","author":"Das","year":"2018","journal-title":"Curr Treat Options Oncol"},{"key":"10.1074\/mcp.RA120.002152_bib30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature13438","article-title":"Proteogenomic characterization of human colon and rectal cancer","volume":"513","author":"Zhang","year":"2014","journal-title":"Nature"},{"key":"10.1074\/mcp.RA120.002152_bib31","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1021\/pr501254j","article-title":"The CPTAC data portal: a resource for cancer proteomics research","volume":"14","author":"Edwards","year":"2015","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.002152_bib32","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1074\/mcp.RA120.002152_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cytogfr.2011.06.003","article-title":"STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNgamma, TLR4 and IL-6 in vascular disease","volume":"22","author":"Sikorski","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1074\/mcp.RA120.002152_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1034\/j.1600-065X.2000.17810.x","article-title":"Human interferon-gamma-mediated immunity is a genetically controlled continuous trait that determines the outcome of mycobacterial invasion","volume":"178","author":"Dupuis","year":"2000","journal-title":"Immunol. Rev"},{"key":"10.1074\/mcp.RA120.002152_bib35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cytogfr.2016.02.010","article-title":"The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses","volume":"29","author":"Blaszczyk","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1074\/mcp.RA120.002152_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3233\/CBM-2006-21-205","article-title":"New aspects in molecular diagnosis of Lynch syndrome (HNPCC)","volume":"2","author":"Fridrichova","year":"2006","journal-title":"Cancer Biomark"},{"key":"10.1074\/mcp.RA120.002152_bib37","first-page":"285","article-title":"The potential value of immunotherapy in colorectal cancers: review of the evidence for programmed death-1 inhibitor therapy","volume":"15","author":"Toh","year":"2016","journal-title":"Clin Colorectal Cancer"},{"key":"10.1074\/mcp.RA120.002152_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.critrevonc.2016.11.016","article-title":"Tumor infiltrating lymphocytes in gastrointestinal tumors: Controversies and future clinical implications","volume":"110","author":"Solinas","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol"},{"key":"10.1074\/mcp.RA120.002152_bib39","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/ijc.25106","article-title":"Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes","volume":"127","author":"Michel","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1074\/mcp.RA120.002152_bib40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.176.2.327","article-title":"Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens","volume":"176","author":"Baixeras","year":"1992","journal-title":"J. Exp. Med"},{"key":"10.1074\/mcp.RA120.002152_bib41","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1172\/JCI31184","article-title":"LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems","volume":"117","author":"Grosso","year":"2007","journal-title":"J. Clin. Invest"},{"key":"10.1074\/mcp.RA120.002152_bib42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)81277-5","article-title":"STATs: signal transducers and activators of transcription","volume":"84","author":"Ihle","year":"1996","journal-title":"Cell"},{"key":"10.1074\/mcp.RA120.002152_bib43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10875-015-0187-8","article-title":"The Ying and Yang of STAT3 in Human Disease","volume":"35","author":"Vogel","year":"2015","journal-title":"J. Clin. Immunol"},{"key":"10.1074\/mcp.RA120.002152_bib44","doi-asserted-by":"crossref","first-page":"9373","DOI":"10.1073\/pnas.0903487106","article-title":"Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes","volume":"106","author":"Cheon","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1074\/mcp.RA120.002152_bib45","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3389\/fimmu.2019.01448","article-title":"Fine-tuning of type I interferon response by STAT3","volume":"10","author":"Tsai","year":"2019","journal-title":"Front. Immunol"},{"key":"10.1074\/mcp.RA120.002152_bib46","doi-asserted-by":"crossref","first-page":"11697","DOI":"10.1038\/s41598-019-48256-4","article-title":"Myeloid maturation potentiates STAT3-mediated atypical IFN-gamma signaling and upregulation of PD-1 ligands in AML and MDS","volume":"9","author":"Yoyen-Ermis","year":"2019","journal-title":"Sci. Rep"},{"key":"10.1074\/mcp.RA120.002152_bib47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00262-012-1303-8","article-title":"T cell responses against microsatellite instability-induced frameshift peptides and influence of regulatory T cells in colorectal cancer","volume":"62","author":"Bauer","year":"2013","journal-title":"Cancer Immunol. Immunother"},{"key":"10.1074\/mcp.RA120.002152_bib48","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/ejhg.2008.81","article-title":"Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours","volume":"16","author":"Dierssen","year":"2008","journal-title":"Eur. J. Hum. Genet"},{"key":"10.1074\/mcp.RA120.002152_bib49","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10689-009-9233-0","article-title":"Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer","volume":"8","author":"Drescher","year":"2009","journal-title":"Fam. Cancer"},{"key":"10.1074\/mcp.RA120.002152_bib50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41568-019-0116-x","article-title":"The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy","volume":"19","author":"Havel","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.RA120.002152_bib51","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.molcel.2013.01.029","article-title":"The coming age of complete, accurate, and ubiquitous proteomes","volume":"49","author":"Mann","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1074\/mcp.RA120.002152_bib52","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.1021\/pr500985w","article-title":"Rapid and deep proteomes by faster sequencing on a benchtop quadrupole ultra-high-field Orbitrap mass spectrometer","volume":"13","author":"Kelstrup","year":"2014","journal-title":"J. Proteome Res"},{"key":"10.1074\/mcp.RA120.002152_bib53","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1074\/mcp.M114.043489","article-title":"The Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer","volume":"13","author":"Scheltema","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.RA120.002152_bib54","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.RA120.002152_bib55","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"10.1074\/mcp.RA120.002152_bib56","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.cellsig.2006.09.003","article-title":"STAT1 as a key modulator of cell death","volume":"19","author":"Kim","year":"2007","journal-title":"Cell. Signal"},{"key":"10.1074\/mcp.RA120.002152_bib57","doi-asserted-by":"crossref","first-page":"e0229252","DOI":"10.1371\/journal.pone.0229252","article-title":"STAT1 as a potential prognosis marker for poor outcomes of early stage colorectal cancer with microsatellite instability","volume":"15","author":"Tanaka","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1074\/mcp.RA120.002152_bib58","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2006.05.025","article-title":"STAT1 acts as a tumor promoter for leukemia development","volume":"10","author":"Kovacic","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1074\/mcp.RA120.002152_bib59","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1074\/jbc.R116.774562","article-title":"The molecular basis for differential type I interferon signaling","volume":"292","author":"Schreiber","year":"2017","journal-title":"J. Biol. Chem"},{"key":"10.1074\/mcp.RA120.002152_bib60","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1128\/MCB.19.1.431","article-title":"Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor beta","volume":"19","author":"Piskurich","year":"1999","journal-title":"Mol. Cell Biol"},{"key":"10.1074\/mcp.RA120.002152_bib61","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1074-7613(00)80468-9","article-title":"Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1","volume":"8","author":"Muhlethaler-Mottet","year":"1998","journal-title":"Immunity"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620351082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620351082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.RA120.002152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:07:05Z","timestamp":1761527225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620351082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S1535947620351082"],"URL":"https:\/\/doi.org\/10.1074\/mcp.ra120.002152","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Proteome Extraction Method Illustrates a Conserved Immunological Signature of MSI-H Colorectal Tumors","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.RA120.002152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Vainer et al.","name":"copyright","label":"Copyright"}]}}