{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:48:50Z","timestamp":1773690530667,"version":"3.50.1"},"reference-count":71,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":8226,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1998,4]]},"DOI":"10.1074\/jbc.273.16.9656","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:04:43Z","timestamp":1027695883000},"page":"9656-9666","source":"Crossref","is-referenced-by-count":176,"title":["Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue"],"prefix":"10.1016","volume":"273","author":[{"given":"Kentaro","family":"Ihara","sequence":"first","affiliation":[]},{"given":"Sachiko","family":"Muraguchi","sequence":"additional","affiliation":[]},{"given":"Masato","family":"Kato","sequence":"additional","affiliation":[]},{"given":"Toshiyuki","family":"Shimizu","sequence":"additional","affiliation":[]},{"given":"Masahiro","family":"Shirakawa","sequence":"additional","affiliation":[]},{"given":"Shinya","family":"Kuroda","sequence":"additional","affiliation":[]},{"given":"Kozo","family":"Kaibuchi","sequence":"additional","affiliation":[]},{"given":"Toshio","family":"Hakoshima","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.273.16.9656_bib1","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1016\/S0021-9258(19)81606-X","volume":"263","author":"Yamamoto","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib2","doi-asserted-by":"crossref","first-page":"12420","DOI":"10.1016\/S0021-9258(18)37772-X","volume":"263","author":"Morii","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0092-8674(85)90058-3","volume":"41","author":"Madaule","year":"1985","journal-title":"Cell"},{"key":"10.1074\/jbc.273.16.9656_bib4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0968-0004(96)10022-0","volume":"21","author":"Simon","year":"1996","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.273.16.9656_bib5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0962-8924(96)10026-X","volume":"6","author":"Machesky","year":"1996","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.273.16.9656_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/oxfordjournals.jbchem.a021401","volume":"120","author":"Narumiya","year":"1996","journal-title":"J. Biochem."},{"key":"10.1074\/jbc.273.16.9656_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0968-0004(00)89022-2","volume":"20","author":"Takai","year":"1995","journal-title":"Trends. Biochem. Sci."},{"key":"10.1074\/jbc.273.16.9656_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.273.5272.245","volume":"273","author":"Kimura","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib9","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1002\/j.1460-2075.1996.tb00574.x","volume":"15","author":"Matsui","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.273.16.9656_bib10","doi-asserted-by":"crossref","first-page":"20246","DOI":"10.1074\/jbc.271.34.20246","volume":"271","author":"Amano","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib11","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1126\/science.275.5304.1308","volume":"275","author":"Amano","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.bi.61.070192.003445","volume":"61","author":"Tan","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.273.16.9656_bib13","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.1128\/MCB.16.10.5313","volume":"16","author":"Leung","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib14","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/j.1460-2075.1996.tb00539.x","volume":"15","author":"Ishizaki","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.273.16.9656_bib15","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.271.5249.648","volume":"271","author":"Amano","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1126\/science.271.5249.645","volume":"271","author":"Watanabe","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib17","doi-asserted-by":"crossref","first-page":"13556","DOI":"10.1074\/jbc.271.23.13556","volume":"271","author":"Reid","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-5793(95)01351-2","volume":"377","author":"Madaule","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.273.16.9656_bib19","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1091\/mbc.7.3.435","volume":"7","author":"Ren","year":"1996","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.273.16.9656_bib20","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1093\/emboj\/16.11.3044","volume":"16","author":"Watanabe","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.273.16.9656_bib21","doi-asserted-by":"crossref","first-page":"23022","DOI":"10.1074\/jbc.271.38.23022","volume":"271","author":"Fujisawa","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib22","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/363364a0","volume":"363","author":"Manser","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/367040a0","volume":"367","author":"Manser","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib24","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1073\/pnas.91.13.5982","volume":"91","author":"Fabian","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.273.16.9656_bib25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0966-842X(97)01067-6","volume":"5","author":"Aktories","year":"1997","journal-title":"Trends Microbiol."},{"key":"10.1074\/jbc.273.16.9656_bib26","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1107\/S0108767393007597","volume":"50","author":"Navara","year":"1994","journal-title":"Acta Crystallogr. Sec. A"},{"key":"10.1074\/jbc.273.16.9656_bib27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1107\/S0108767390002355","volume":"46","author":"Brunger","year":"1990","journal-title":"Acta Crystallogr. Sec. A"},{"key":"10.1074\/jbc.273.16.9656_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1107\/S090744499500761X","volume":"52","author":"Cowtan","year":"1996","journal-title":"Acta Crystallogr. Sec. D"},{"key":"10.1074\/jbc.273.16.9656_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. Sec. A"},{"key":"10.1074\/jbc.273.16.9656_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.273.16.9656_bib31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1126\/science.2406906","volume":"247","author":"Milburn","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib32","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/j.1460-2075.1990.tb07409.x","volume":"9","author":"Pai","year":"1990","journal-title":"EMBO J."},{"key":"10.1074\/jbc.273.16.9656_bib33","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/372704a0","volume":"372","author":"Amor","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib34","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/374378a0","volume":"374","author":"Scheffzek","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/375554a0","volume":"375","author":"Nassar","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib36","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nsb0297-147","volume":"4","author":"Hirshberg","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0092-8674(90)90018-A","volume":"62","author":"Krengel","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.273.16.9656_bib38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nsb0997-699","volume":"4","author":"Wei","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0022-2836(91)90753-S","volume":"217","author":"Tong","year":"1991","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/345309a0","volume":"345","author":"Schlichting","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib41","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/369621a0","volume":"369","author":"Lambright","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(86)90495-2","volume":"44","author":"Der","year":"1986","journal-title":"Cell"},{"key":"10.1074\/jbc.273.16.9656_bib43","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0968-0004(93)90175-M","volume":"18","author":"Marshall","year":"1993","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.273.16.9656_bib44","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/366654a0","volume":"366","author":"Noel","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib45","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1126\/science.8073283","volume":"265","author":"Coleman","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib46","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/365126a0","volume":"365","author":"Berchtold","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib47","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1016\/S0021-9258(18)81834-8","volume":"264","author":"Sekine","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib48","doi-asserted-by":"crossref","first-page":"7646","DOI":"10.1016\/S0021-9258(20)89496-4","volume":"266","author":"Morii","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0092-8674(94)90259-3","volume":"79","author":"Chong","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.273.16.9656_bib50","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1016\/S0021-9258(19)50014-X","volume":"267","author":"Just","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib51","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1242\/jcs.107.6.1653","volume":"107","author":"Just","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.273.16.9656_bib52","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/375500a0","volume":"375","author":"Just","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib53","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/42735","volume":"387","author":"Schmidt","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib54","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/42743","volume":"387","author":"Flatau","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib55","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1126\/science.270.5238.954","volume":"270","author":"Mixon","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.273.16.9656_bib56","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1093\/emboj\/16.18.5582","volume":"16","author":"Cherfils","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.273.16.9656_bib57","first-page":"655","volume":"8","author":"Self","year":"1993","journal-title":"Oncogene"},{"key":"10.1074\/jbc.273.16.9656_bib58","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nsb0896-723","volume":"3","author":"Nassar","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib59","doi-asserted-by":"crossref","first-page":"19794","DOI":"10.1074\/jbc.271.33.19794","volume":"271","author":"Freeman","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib60","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0955-0674(96)80068-8","volume":"8","author":"Cerione","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib61","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1074\/jbc.270.16.9031","volume":"270","author":"Zheng","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib62","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0092-8674(94)90216-X","volume":"77","author":"Habets","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.273.16.9656_bib63","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/354311a0","volume":"354","author":"Hart","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib64","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1074\/jbc.272.8.4671","volume":"272","author":"Li","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib65","first-page":"2873","volume":"11","author":"Kaibuchi","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.273.16.9656_bib66","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1006\/bbrc.1994.1116","volume":"198","author":"Yaku","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.273.16.9656_bib67","doi-asserted-by":"crossref","first-page":"14611","DOI":"10.1016\/S0021-9258(18)42085-6","volume":"267","author":"Kikuchi","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib68","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1016\/S0021-9258(19)38260-2","volume":"265","author":"Araki","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.16.9656_bib69","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/42961","volume":"387","author":"Gosser","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.273.16.9656_bib70","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0969-2126(97)00218-9","volume":"5","author":"Keep","year":"1997","journal-title":"Structure (Lond.)"},{"key":"10.1074\/jbc.273.16.9656_bib71","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/41805","volume":"388","author":"Rittinger","year":"1997","journal-title":"Nature"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818461820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818461820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.273.16.9656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T07:03:34Z","timestamp":1639811014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818461820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":71,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["S0021925818461820"],"URL":"https:\/\/doi.org\/10.1074\/jbc.273.16.9656","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}