{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:26:40Z","timestamp":1772782000035,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":6354,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1074\/jbc.m213107200","type":"journal-article","created":{"date-parts":[[2003,5,24]],"date-time":"2003-05-24T02:54:02Z","timestamp":1053744842000},"page":"20117-20123","source":"Crossref","is-referenced-by-count":75,"title":["Membrane Topology of \u03b3-Secretase Component PEN-2"],"prefix":"10.1016","volume":"278","author":[{"given":"Adam S.","family":"Crystal","sequence":"first","affiliation":[]},{"given":"Vanessa A.","family":"Morais","sequence":"additional","affiliation":[]},{"given":"Theodore C.","family":"Pierson","sequence":"additional","affiliation":[]},{"given":"Donald S.","family":"Pijak","sequence":"additional","affiliation":[]},{"given":"Dan","family":"Carlin","sequence":"additional","affiliation":[]},{"given":"Virginia M.-Y.","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Robert W.","family":"Doms","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M213107200_bib1","first-page":"7374","volume":"277","author":"Gu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib2","doi-asserted-by":"crossref","first-page":"45013","DOI":"10.1074\/jbc.M208164200","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib3","doi-asserted-by":"crossref","first-page":"6138","DOI":"10.1073\/pnas.110126897","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M213107200_bib4","doi-asserted-by":"crossref","first-page":"39062","DOI":"10.1074\/jbc.C200469200","volume":"277","author":"Steiner","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/35024009","volume":"407","author":"Yu","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M213107200_bib6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"Vassar","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M213107200_bib7","doi-asserted-by":"crossref","first-page":"9299","DOI":"10.1073\/pnas.97.16.9299","volume":"97","author":"Xia","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M213107200_bib8","doi-asserted-by":"crossref","first-page":"31894","DOI":"10.1074\/jbc.271.50.31894","volume":"271","author":"Wang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib9","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M213107200_bib10","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.M213107200_bib11","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M213107200_bib12","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M213107200_bib13","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M213107200_bib14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/35015085","volume":"405","author":"Li","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M213107200_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1534-5807(02)00189-2","volume":"3","author":"Francis","year":"2002","journal-title":"Dev Cell."},{"key":"10.1074\/jbc.M213107200_bib16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.022523499","volume":"99","author":"Goutte","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M213107200_bib17","doi-asserted-by":"crossref","first-page":"8666","DOI":"10.1073\/pnas.132277899","volume":"99","author":"Edbauer","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M213107200_bib18","doi-asserted-by":"crossref","first-page":"19236","DOI":"10.1074\/jbc.C200148200","volume":"277","author":"Leem","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib19","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1074\/jbc.C200648200","volume":"278","author":"Luo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib20","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0896-6273(00)80232-9","volume":"17","author":"Doan","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.M213107200_bib21","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0896-6273(00)80231-7","volume":"17","author":"Li","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.M213107200_bib22","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1073\/pnas.95.12.7109","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M213107200_bib23","doi-asserted-by":"crossref","first-page":"23647","DOI":"10.1074\/jbc.274.33.23647","volume":"274","author":"Nakai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib24","doi-asserted-by":"crossref","first-page":"28135","DOI":"10.1074\/jbc.M110871200","volume":"277","author":"Yang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev.bi.54.070185.003215","volume":"54","author":"Kornfeld","year":"1985","journal-title":"Ann. Rev. Biochem."},{"key":"10.1074\/jbc.M213107200_bib26","doi-asserted-by":"crossref","first-page":"18572","DOI":"10.1016\/S0021-9258(17)32347-5","volume":"269","author":"Chang","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib27","doi-asserted-by":"crossref","first-page":"27981","DOI":"10.1074\/jbc.M100518200","volume":"276","author":"Hamilton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib28","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1074\/jbc.273.15.8675","volume":"273","author":"Vannier","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib29","doi-asserted-by":"crossref","first-page":"33729","DOI":"10.1074\/jbc.M004175200","volume":"275","author":"Huse","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm0296-224","volume":"2","author":"Kovacs","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M213107200_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0968-0004(94)90205-4","volume":"19","author":"Bergeron","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M213107200_bib32","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1083\/jcb.131.6.1715","volume":"131","author":"Nakamura","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M213107200_bib33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrm910","volume":"3","author":"Fortini","year":"2002","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1074\/jbc.M213107200_bib34","doi-asserted-by":"crossref","first-page":"16470","DOI":"10.1074\/jbc.273.26.16470","volume":"273","author":"Yu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M213107200_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1042\/bj3490051","volume":"349","author":"Li","year":"2000","journal-title":"Biochem. J"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820800386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820800386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M213107200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T07:25:04Z","timestamp":1655018704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820800386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":35,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["S0021925820800386"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m213107200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}