{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:37:46Z","timestamp":1773283066572,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":5988,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1074\/jbc.m311388200","type":"journal-article","created":{"date-parts":[[2004,4,30]],"date-time":"2004-04-30T19:33:48Z","timestamp":1083353628000},"page":"19665-19682","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":93,"title":["Pro-apoptotic Proteins Released from the Mitochondria Regulate the Protein Composition and Caspase-processing Activity of the Native Apaf-1\/Caspase-9 Apoptosome Complex"],"prefix":"10.1016","volume":"279","author":[{"given":"Davina","family":"Twiddy","sequence":"first","affiliation":[]},{"given":"David G.","family":"Brown","sequence":"additional","affiliation":[]},{"given":"Colin","family":"Adrain","sequence":"additional","affiliation":[]},{"given":"Rebekah","family":"Jukes","sequence":"additional","affiliation":[]},{"given":"Seamus J.","family":"Martin","sequence":"additional","affiliation":[]},{"given":"Gerald M.","family":"Cohen","sequence":"additional","affiliation":[]},{"given":"Marion","family":"MacFarlane","sequence":"additional","affiliation":[]},{"given":"Kelvin","family":"Cain","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M311388200_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M311388200_bib2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1126\/science.281.5381.1298","volume":"281","author":"Hengartner","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M311388200_bib3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev.biochem.68.1.383","volume":"68","author":"Earnshaw","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M311388200_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0092-8674(00)81182-4","volume":"93","author":"Conradt","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib5","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.287.5457.1485","volume":"287","author":"Chen","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M311388200_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/excr.2000.4835","volume":"256","author":"Bratton","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M311388200_bib7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0968-0004(01)01844-8","volume":"26","author":"Adrain","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M311388200_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0300-9084(02)01376-7","volume":"84","author":"Cain","year":"2002","journal-title":"Biochimie (Paris)"},{"key":"10.1074\/jbc.M311388200_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0092-8674(00)80085-9","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib10","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0092-8674(00)80501-2","volume":"90","author":"Zou","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(00)80434-1","volume":"91","author":"Li","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib12","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/j.1460-2075.1982.tb01276.x","volume":"1","author":"Walker","year":"1982","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M311388200_bib13","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.1074\/jbc.275.12.8461","volume":"275","author":"Benedict","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib14","doi-asserted-by":"crossref","first-page":"22686","DOI":"10.1074\/jbc.274.32.22686","volume":"274","author":"Cain","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib15","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1074\/jbc.275.9.6067","volume":"275","author":"Cain","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib16","doi-asserted-by":"crossref","first-page":"17941","DOI":"10.1074\/jbc.274.25.17941","volume":"274","author":"Saleh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib17","doi-asserted-by":"crossref","first-page":"11549","DOI":"10.1074\/jbc.274.17.11549","volume":"274","author":"Zou","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.1076807","volume":"299","author":"Jiang","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M311388200_bib19","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1038\/sj.leu.2402201","volume":"15","author":"Almond","year":"2001","journal-title":"Leukemia"},{"key":"10.1074\/jbc.M311388200_bib20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/26261","volume":"395","author":"Rothwarf","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M311388200_bib21","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0092-8674(00)80380-3","volume":"90","author":"Horiuchi","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib22","doi-asserted-by":"crossref","first-page":"36611","DOI":"10.1074\/jbc.M200317200","volume":"277","author":"MacFarlane","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib23","doi-asserted-by":"crossref","first-page":"41985","DOI":"10.1074\/jbc.M107419200","volume":"276","author":"Cain","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib24","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/sj.cdd.4401069","volume":"9","author":"Bratton","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M311388200_bib25","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1101\/gad.13.24.3179","volume":"13","author":"Rodriguez","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M311388200_bib26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/21124","volume":"399","author":"Qin","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M311388200_bib27","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/emboj\/20.5.998","volume":"20","author":"Bratton","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M311388200_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/35065125","volume":"410","author":"Srinivasula","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M311388200_bib29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1097-2765(03)00054-6","volume":"11","author":"Shiozaki","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M311388200_bib30","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0092-8674(01)00274-4","volume":"104","author":"Riedl","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib31","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(01)00272-0","volume":"104","author":"Chai","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/sj.cdd.4400834","volume":"8","author":"Bratton","year":"2001","journal-title":"Cell Death. Differ."},{"key":"10.1074\/jbc.M311388200_bib33","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1093\/emboj\/18.19.5242","volume":"18","author":"Deveraux","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M311388200_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0092-8674(00)00008-8","volume":"102","author":"Du","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M311388200_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1083\/jcb.153.1.221","volume":"153","author":"Roberts","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M311388200_bib36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrm830","volume":"3","author":"Salvesen","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1074\/jbc.M311388200_bib37","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1074\/jbc.274.13.8359","volume":"274","author":"Stennicke","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/emboj\/18.1.179","volume":"18","author":"Yamaguchi","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M311388200_bib39","doi-asserted-by":"crossref","first-page":"38699","DOI":"10.1074\/jbc.M303179200","volume":"278","author":"Hegde","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib40","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1074\/jbc.M204783200","volume":"278","author":"Zou","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib41","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.200303123","volume":"162","author":"Rehm","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M311388200_bib42","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ncb1005","volume":"5","author":"Allan","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M311388200_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1097-2765(05)00021-3","volume":"6","author":"Chau","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M311388200_bib44","doi-asserted-by":"crossref","first-page":"9239","DOI":"10.1074\/jbc.M006309200","volume":"276","author":"Chu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M311388200_bib45","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/35019501","volume":"2","author":"Beere","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M311388200_bib46","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/35019510","volume":"2","author":"Saleh","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M311388200_bib47","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.1093\/emboj\/19.16.4310","volume":"19","author":"Pandey","year":"2000","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M311388200_bib48","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1097-2765(02)00442-2","volume":"9","author":"Acehan","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M311388200_bib49","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1073\/pnas.220416197","volume":"97","author":"Purring-Koch","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820670752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820670752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M311388200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T22:39:59Z","timestamp":1635374399000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820670752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":49,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0021925820670752"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m311388200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}