{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:27:33Z","timestamp":1754152053841,"version":"3.41.2"},"reference-count":26,"publisher":"Swets & Zeitlinger Publishers","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Ophthalmology"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1076\/soph.17.1.33.10288","type":"journal-article","created":{"date-parts":[[2003,3,13]],"date-time":"2003-03-13T04:34:51Z","timestamp":1047530091000},"page":"33-38","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of Leber's hereditary optic neuropathy: theory to practice"],"prefix":"10.1076","volume":"17","author":[{"given":"Donald R.","family":"Johns","sequence":"first","affiliation":[{"name":"Departments of Neurology Boston, MA, USA"},{"name":"Departments of Ophthalmology Boston, MA, USA"},{"name":"Departments of Harvard Medical School, the Beth\u2013Israel\u2013Deaconess Medical Center Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn A.","family":"Colby","sequence":"additional","affiliation":[{"name":"Departments of the Massachusetts Eye and Ear Infirmary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"191","published-online":{"date-parts":[[2009,7,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"146","article-title":"Genotype-specific phenotypes in Leber\u2019s hered- itary optic neuropathy","volume":"2","author":"Johns DR.","year":"1994","unstructured":"Johns DR. Genotype-specific phenotypes in Leber\u2019s hered- itary optic neuropathy. Clin Neurosci. 1994;2:146\u2013150.","journal-title":"Clin Neurosci"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1993.00540050082021"},{"volume-title":"Aust NZ J Ophthalmol","author":"Mackey DA","key":"e_1_2_1_4_1","unstructured":"Mackey DA, Buttery RG. Leber hereditary optic neuropa- thy in Australia. Aust NZ J Ophthalmol. 1992;20:177\u2013 184."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509073331007"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1096-1065","article-title":"The other human genome: mitochondrial DNA and disease","volume":"10","author":"Johns DR.","year":"1996","unstructured":"Johns DR. The other human genome: mitochondrial DNA and disease. Nature Med. 1996;10:1065\u20131068.","journal-title":"Nature Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0896-1549(01)00016-5","article-title":"Mechanisms of disease: Fuchs\u2019 endothelial dystrophy","volume":"15","author":"Borboli S","year":"2002","unstructured":"Borboli S, Colby KA. Mechanisms of disease: Fuchs\u2019 endothelial dystrophy. Ophthalmol Clinics of North America. 2002;15:1\u20139.","journal-title":"Ophthalmol Clinics of North America"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Johns DR. The ophthalmologic manifestations of mito- chondrial disease. Seminars Ophthalmol . 1995;10:295\u2013 302.","DOI":"10.3109\/08820539509063800"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090040087038"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.10.1634041"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090110057023"},{"key":"e_1_2_1_12_1","first-page":"956","article-title":"Identical twins no longer discordant for Leber\u2019s hereditary optic neuropathy","volume":"116","author":"Lam BL.","year":"1998","unstructured":"Lam BL. Identical twins no longer discordant for Leber\u2019s hereditary optic neuropathy. Arch Ophthalmol. 1998;116:956\u2013957.","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090110048021"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.5.577"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00603-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01301-0"},{"key":"e_1_2_1_17_1","first-page":"276","article-title":"Molecular genetics of glaucoma: current status","volume":"5","author":"Alward WL","year":"1996","unstructured":"Alward WL, Johnson AT, Nishimura DY, Sheffield VC, Stone EM. Molecular genetics of glaucoma: current status. J Glaucoma. 1996;5:276\u2013284.","journal-title":"J Glaucoma"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5482.1150"},{"first-page":"S241","volume-title":"Surv Ophthalmol","key":"e_1_2_1_19_1","unstructured":"Neuroprotection: Possibilities in Perspective. Surv Ophthalmol. 2001;45(Suppl 3):S241\u2013S334."},{"key":"e_1_2_1_20_1","first-page":"774","article-title":"Retinal ganglion cell death in experi- mental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"Quigley HA","year":"1995","unstructured":"Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, Zack DJ. Retinal ganglion cell death in experi- mental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci. 1995;36:774\u2013786.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100130484027"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","unstructured":"Mashima Y Hiida Y Oguchi Y. Remission of Leber\u2019s hered- itary optic neuropathy with idebenone [letter] Lancet . 1992:240;368\u2013369.","DOI":"10.1016\/0140-6736(92)91442-B"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00311-5"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-1602-5_32"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-1-4612-1602-5_13","volume-title":"Cell Death and Diseases of the Nervous System","author":"Flanigan KM","year":"1999","unstructured":"Flanigan KM, Ratan RR. Cell death and the mitochondrial encephalomyopathies. In: Koliatsos VE, Ratan RR, eds., Cell Death and Diseases of the Nervous System. Human Press, Totowa, NJ, 1999, pp. 275\u2013293."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7443"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00790-2"}],"container-title":["Seminars in Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1076\/soph.17.1.33.10288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:12:53Z","timestamp":1753099973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1076\/soph.17.1.33.10288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1076\/soph.17.1.33.10288"],"URL":"https:\/\/doi.org\/10.1076\/soph.17.1.33.10288","relation":{},"ISSN":["0882-0538","1744-5205"],"issn-type":[{"type":"print","value":"0882-0538"},{"type":"electronic","value":"1744-5205"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}