{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:01:28Z","timestamp":1790744488527,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1078\/0344-0338-00421","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T13:02:24Z","timestamp":1124370144000},"page":"293-302","source":"Crossref","is-referenced-by-count":35,"title":["Disappearance of CD21-positive Follicular Dendritic Cells Preceding the Transformation of Follicular Lymphoma: Immunohistological Study of the Transformation Using CD21, p53, Ki-67, and P-glycoprotein"],"prefix":"10.1078","volume":"199","author":[{"given":"Eisuke","family":"Shiozawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Yamochi-Onizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadanori","family":"Yamochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutsuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Naitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Nakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Tomoyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Kushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1078\/0344-0338-00421_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/bjc.1995.292","article-title":"p53 mutation and expression in lymphoma","volume":"72","author":"Adamson","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1078\/0344-0338-00421_bib2","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/ajcp\/101.6.761","article-title":"Follicular dendritic cells have prognostic relevance in Hodgkin's disease","volume":"101","author":"Alavaikko","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1078\/0344-0338-00421_bib3","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V89.11.3909","article-title":"A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. The Non-Hodgkin's Lymphoma Classification Project","volume":"89","author":"Anonymous","year":"1997","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib4","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood.V81.9.2215.2215","article-title":"Clinical significance of P-glycoprotein in multidrug resistance malignancies","volume":"81","author":"Arceci","year":"1993","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/jnci\/80.8.576","article-title":"Correlation of secondary cytogenetic abnormalities with histologic appearance in non-Hodgkin's lymphomas bearing t (14;18) (q32;q21)","volume":"80","author":"Armitage","year":"1988","journal-title":"J Natl Cancer Inst"},{"key":"10.1078\/0344-0338-00421_bib6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00022744-200106000-00003","article-title":"Follicular dendritic cells in reactive and neoplastic lymphoid tissues: A reevaluation of staining patterns of CD21, CD23, and CD35 antibodies in paraffin sections after wet heat-induced epitope retrieval","volume":"9","author":"Bagdi","year":"2001","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1078\/0344-0338-00421_bib7","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2559.1998.t01-1-00418.x","article-title":"Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease","volume":"32","author":"Baur","year":"1998","journal-title":"Histopathol"},{"key":"10.1078\/0344-0338-00421_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/(SICI)1096-9896(199707)182:3<307::AID-PATH873>3.0.CO;2-6","article-title":"bcl-2 and p53 protein expression in follicular lymphoma","volume":"182","author":"Cooper","year":"1997","journal-title":"J Pathol"},{"key":"10.1078\/0344-0338-00421_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regressions model and life table","volume":"34","author":"Cox","year":"1972","journal-title":"J Roy Statist Soc"},{"key":"10.1078\/0344-0338-00421_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/1097-0142(197908)44:2<645::AID-CNCR2820440234>3.0.CO;2-Y","article-title":"Histological transformation of non-Hodgkin's lymphoma: a prospective study","volume":"44","author":"Cullen","year":"1979","journal-title":"Cancer"},{"key":"10.1078\/0344-0338-00421_bib11","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1182\/blood.V91.12.4677","article-title":"Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle center lymphoma","volume":"91","author":"Elenitoba-Johnson","year":"1998","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib12","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/1097-0142(19830801)52:3<393::AID-CNCR2820520302>3.0.CO;2-M","article-title":"An autopsy study of histologic progression in non-Hodgkin's lymphomas: 192 cases from the National Cancer institute","volume":"52","author":"Garvin","year":"1983","journal-title":"Cancer"},{"key":"10.1078\/0344-0338-00421_bib13","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1182\/blood.V71.4.1157.1157","article-title":"Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67","volume":"71","author":"Grogan","year":"1988","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib14","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group","volume":"84","author":"Harris","year":"1994","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1097\/00000478-199808000-00005","article-title":"Characteristic proliferations of reticular and dendritic cells in angioimmunoblastic lymphoma","volume":"22","author":"Jones","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1078\/0344-0338-00421_bib16","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.184.4.1495","article-title":"Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells","volume":"184","author":"Kanzler","year":"1996","journal-title":"J Exp Med"},{"key":"10.1078\/0344-0338-00421_bib17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2307\/2281868","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1078\/0344-0338-00421_bib18","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1182\/blood.V90.10.4078","article-title":"Correlation between mutation in P53, p53 expression, cytogenetics, histologic type, and survival in patients with B-cell non-Hodgkin's lymphoma","volume":"90","author":"Koduru","year":"1997","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib19","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1172\/JCI114320","article-title":"Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma","volume":"84","author":"Lee","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1078\/0344-0338-00421_bib20","series-title":"Handbuch der speziellen pathologischen Anatomie und Histologie, Bd 3, Teil B","first-page":"502","article-title":"Malignant lymphomas other than Hodgkin's disease. Histology, cytology, ultrastructure, immunology","author":"Lennert","year":"1978"},{"key":"10.1078\/0344-0338-00421_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2559.1993.tb00491.x","article-title":"Usefulness of follicular dendritic cell pattern in classification of peripheral T-cell lymphomas","volume":"23","author":"Leung","year":"1993","journal-title":"Histopathology"},{"key":"10.1078\/0344-0338-00421_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/351453a0","article-title":"The p53 tumour suppressor gene","volume":"351","author":"Levine","year":"1991","journal-title":"Nature"},{"key":"10.1078\/0344-0338-00421_bib23","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/eji.1830210504","article-title":"Recombinant 25-kDa CD23 and interleukin 1 alpha promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis","volume":"21","author":"Liu","year":"1991","journal-title":"Eur J Immunol"},{"key":"10.1078\/0344-0338-00421_bib24","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1385\/MO:18:1:15","article-title":"Prognostic significance of Ki-67 nuclear proliferative antigen, bcl-2 protein, and p53 expression in follicular and diffuse large B-cell lymphoma","volume":"18","author":"Llanos","year":"2001","journal-title":"Med Oncol"},{"key":"10.1078\/0344-0338-00421_bib25","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1182\/blood.V82.8.2289.2289","article-title":"p53 mutations are associated with histologic transformation of follicular lymphoma","volume":"82","author":"Lo Coco","year":"1993","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib26","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","article-title":"Germinal centers","volume":"12","author":"MacLennan","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1078\/0344-0338-00421_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.1980.tb01039.x","article-title":"The follicular dendritic cell: long term antigen retention during immunity","volume":"53","author":"Mandel","year":"1980","journal-title":"Immunol Rev"},{"key":"10.1078\/0344-0338-00421_bib28","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1182\/blood.V95.4.1443.004k55_1443_1450","article-title":"Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription","volume":"95","author":"Marafioti","year":"2000","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib29","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1182\/blood.V88.10.3937.bloodjournal88103937","article-title":"Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene","volume":"88","author":"Matolcsy","year":"1996","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib30","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood.V83.6.1460.1460","article-title":"Prognostic significance of the Ki-67 associated proliferative antigen in aggressive non-Hodgkin's lymphomas: a prospective Southwest Oncology Group trial","volume":"83","author":"Miller","year":"1994","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/jcp.36.2.167","article-title":"Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue","volume":"36","author":"Naiem","year":"1983","journal-title":"J Clin Pathol"},{"key":"10.1078\/0344-0338-00421_bib32","series-title":"World Health Organization classification of tumors: pathology and genetics of tumours of haematopoietic and lymphoid tissues","first-page":"162","article-title":"Follicular lymphoma","author":"Nathwani","year":"2001"},{"key":"10.1078\/0344-0338-00421_bib33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/1097-0142(19840301)53:5<1109::AID-CNCR2820530516>3.0.CO;2-O","article-title":"Malignant lymphomas of follicular center cell origin in humans. V. Incidence, clinical features, and prognostic implications of transformation of small cleaved cell nodular lymphoma","volume":"53","author":"Oviatt","year":"1984","journal-title":"Cancer"},{"key":"10.1078\/0344-0338-00421_bib34","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2307\/2344317","article-title":"Asymptotically efficient rank invariant test procedures","volume":"35","author":"Peto","year":"1972","journal-title":"J Roy Statist Soc A"},{"key":"10.1078\/0344-0338-00421_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/10428199409051675","article-title":"Follicular dendritic cells in non-Hodgkin's lymphomas","volume":"15","author":"Petrasch","year":"1994","journal-title":"Leuk Lymphoma"},{"key":"10.1078\/0344-0338-00421_bib36","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1182\/blood.V91.8.2977.2977_2977_2984","article-title":"p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas","volume":"91","author":"Pinyol","year":"1998","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib37","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.4049\/jimmunol.161.9.4549","article-title":"Evidence for an important interaction between a complement-derived CD21 ligand on follicular dendritic cells and CD21 on B cells in the initiation of IgG responses","volume":"161","author":"Qin","year":"1998","journal-title":"J Immunol"},{"key":"10.1078\/0344-0338-00421_bib38","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/blood.V70.2.444.444","article-title":"Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes","volume":"70","author":"Richardson","year":"1987","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/316817a0","article-title":"Amplification of P-glycoprotein genes in multidrugresistant mammalian cell lines","volume":"316","author":"Riordan","year":"1985","journal-title":"Nature"},{"key":"10.1078\/0344-0338-00421_bib40","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1182\/blood.V82.7.1994.1994","article-title":"p53 mutation is associated with progression in follicular lymphomas","volume":"82","author":"Sander","year":"1993","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib41","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1182\/blood.V95.10.3020","article-title":"Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease","volume":"95","author":"Seitz","year":"2000","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0308-2261(82)80005-2","article-title":"The normal and malignant germinal center","volume":"11","author":"Stein","year":"1982","journal-title":"Clin Haematol"},{"key":"10.1078\/0344-0338-00421_bib43","first-page":"673","article-title":"Transformation of follicular lymphoma. Expression of p53 and bcl-2 oncoprotein, apoptosis and cell proliferation","volume":"39","author":"Symmans","year":"1995","journal-title":"Acta Cytol"},{"key":"10.1078\/0344-0338-00421_bib44","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0002-9440(10)64969-3","article-title":"Somatic mutation of the 5\u2032 noncoding region of the BCL-6 gene is associated with intraclonal diversity and clonal selection in histological transformation of follicular lymphoma","volume":"156","author":"Szereday","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1078\/0344-0338-00421_bib45","first-page":"470","article-title":"Distribution pattern of follicular dendritic cells in low grade B-cell lymphomas of the gastrointestinal tract immunostained by Ki-FDC1p: a new paraffin-resistant monoclonal antibody","volume":"3","author":"Tabrizchi","year":"1990","journal-title":"Mod Pathol"},{"key":"10.1078\/0344-0338-00421_bib46","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-065X.1990.tb00573.x","article-title":"Follicular dendritic cells as accessory cells","volume":"117","author":"Tew","year":"1990","journal-title":"Immunol Rev"},{"key":"10.1078\/0344-0338-00421_bib47","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJM199309303291402","article-title":"A predictive model for aggressive non-Hodgkin's lymphoma","volume":"329","author":"The International Non-Hodgkin's Lymphoma Prognostic Factors Project","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1078\/0344-0338-00421_bib48","first-page":"381","article-title":"The physiology of germinal centers","volume":"16","author":"Tsiagbe","year":"1996","journal-title":"Crit Rev Immunol"},{"key":"10.1078\/0344-0338-00421_bib49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1182\/blood.V89.2.601","article-title":"Relationship of p53, bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas","volume":"89","author":"Wilson","year":"1997","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib50","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1182\/blood.V80.3.758.758","article-title":"MYC rearrangements in histologically progressed follicular lymphomas","volume":"80","author":"Yano","year":"1992","journal-title":"Blood"},{"key":"10.1078\/0344-0338-00421_bib51","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1200\/JCO.1994.12.11.2453","article-title":"Multidrug resistance in lymphomas","volume":"12","author":"Yuen","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1078\/0344-0338-00421_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1056\/NEJM198701083160204","article-title":"Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer","volume":"316","author":"Yunis","year":"1987","journal-title":"N Engl J Med"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033804704197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033804704197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T16:43:57Z","timestamp":1735922637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033804704197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0344033804704197"],"URL":"https:\/\/doi.org\/10.1078\/0344-0338-00421","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}