{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:09:50Z","timestamp":1787540990104,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytomedicine"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1078\/094471103322004866","type":"journal-article","created":{"date-parts":[[2003,6,13]],"date-time":"2003-06-13T17:25:30Z","timestamp":1055525130000},"page":"348-357","source":"Crossref","is-referenced-by-count":160,"title":["Chaste tree (Vitex agnus-castus) \u2013 Pharmacology and clinical indications"],"prefix":"10.1078","volume":"10","author":[{"given":"W.","family":"Wuttke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Jarry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Christoffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Seidlov\u00e1-Wuttke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1078\/094471103322004866_bib1","series-title":"Phyto-Pharmaka V \u2014 Forschung und klinische Anwendung","first-page":"209","article-title":"Prolactin inhibiting dopaminergic activity of diterpenes from Vitex agnus castus","author":"Christoffel","year":"1999"},{"key":"10.1078\/094471103322004866_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1210\/er.20.3.358","article-title":"Estrogen receptor null mice: What have we learned and where will they lead us?","volume":"20","author":"Couse","year":"1999","journal-title":"Endocr Rev"},{"key":"10.1078\/094471103322004866_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000021154","article-title":"Mastodynon\u00ae bei weiblicher Sterilit\u00e4t \u2014 Randomisierte, plazebokontrollierte, klinische Doppelblindstudie","volume":"5","author":"Gerhard","year":"1998","journal-title":"Forsch Komplement\u00e4rmed"},{"key":"10.1078\/094471103322004866_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1054\/brst.1999.0039","article-title":"Treatment of cyclical mastalgia with a solution containing a Vitex agnus castus extract: results of a placebo-controlled double-blind study","volume":"8","author":"Halaska","year":"1999","journal-title":"The Breast"},{"key":"10.1078\/094471103322004866_bib5","first-page":"140","article-title":"Diterpene aus Agni-casti fructus und ihre Analytik","volume":"20","author":"Hoberg","year":"1999","journal-title":"Zeitschrift fur Phytotherapie"},{"key":"10.1078\/094471103322004866_bib6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1055\/s-0029-1211317","article-title":"In vitro prolactin but not LH and FSH release is inhibited by compounds in extracts of Agnus castus: direct evidence for a dopaminergic principle by the dopamine receptor assay","volume":"102","author":"Jarry","year":"1994","journal-title":"Exp Clin Endocrinol"},{"key":"10.1078\/094471103322004866_bib7","first-page":"77","article-title":"Agnus castus als dopaminerges Wirkprinzip in Mastodynon N","volume":"12","author":"Jarry","year":"1991","journal-title":"Zeitschrift f\u00fcr Phytotherapie"},{"key":"10.1078\/094471103322004866_bib8","first-page":"150","article-title":"Auf der Suche nach dopaminergen Substanzen in Agni-casti-fructus-Pr\u00e4paraten: Warum eigentlich?","volume":"20","author":"Jarry","year":"1999","journal-title":"Zeitschrift f\u00fcr Phytotherapie"},{"key":"10.1078\/094471103322004866_bib9","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1073\/pnas.93.12.5925","article-title":"Cloning of a novel receptor expressed in rat prostate and ovary","volume":"93","author":"Kuiper","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1078\/094471103322004866_bib10","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/en.139.10.4252","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor \u03b2","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1078\/094471103322004866_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0944-7113(97)80066-9","article-title":"Treatment of premenstrual tension syndrome with Vitex agnus castus \u2014 Controlled, double-blind study versus pyridoxine","volume":"4","author":"Lauritzen","year":"1997","journal-title":"Phytomedicine"},{"key":"10.1078\/094471103322004866_bib12","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1073\/pnas.96.12.7077","article-title":"Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors \u03b1 and \u03b2","volume":"96","author":"M\u00e4kel\u00e4","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1078\/094471103322004866_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0140-6736(90)90278-D","article-title":"European multicentre trial of bromocriptine in cyclical mastalgia","volume":"335","author":"Mansel","year":"1990","journal-title":"The LANCET"},{"key":"10.1078\/094471103322004866_bib14","first-page":"752","article-title":"Vitex agnus castus-Extrakt zur Behandlung von Regeltempoanomalien infolge latenter Hyperprolaktin\u00e4mie \u2014 Ergebnisse einer randomisierten Plazebokontrollierten Doppelblindstudie","volume":"43","author":"Milewicz","year":"1993","journal-title":"Arzneim Forsch\/Drug Res"},{"key":"10.1078\/094471103322004866_bib15","first-page":"157","article-title":"Therapie von Zyklusst\u00f6rungen mit Vitex agnus-castus","volume":"3","author":"Roeder","year":"1994","journal-title":"Zeitschrift f\u00fcr Phytotherapie"},{"key":"10.1078\/094471103322004866_bib16","series-title":"Lisuride and Other Dopamine Agonists","first-page":"345","article-title":"EEG and psychological effects of lisuride in women with premenstrual tension","author":"Schwibbe","year":"1983"},{"key":"10.1078\/094471103322004866_bib17","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1073\/pnas.97.11.5936","article-title":"Estrogen receptor (ER)\u03b2, a modulator of ER\u03b1 in the uterus","volume":"97","author":"Weihua","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1078\/094471103322004866_bib18","series-title":"Phyto-Pharmaka \u2014Forschung und klinische Anwendung","first-page":"81","article-title":"Dopaminergic compounds in Vitex agnus castus","author":"Wuttke","year":"1995"},{"key":"10.1078\/094471103322004866_bib19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1055\/s-2007-1023139","article-title":"Behandlung zyklusabh\u00e4ngiger Brustschmerzen mit einem Agnus castus-haltigen Arzneimittel \u2014 Ergebnisse einer randomisierten, plazebokontrollierten Doppelblindstudie","volume":"57","author":"Wuttke","year":"1997","journal-title":"Geburtsh u Frauenheilk"},{"key":"10.1078\/094471103322004866_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0083-6729(01)63005-X","article-title":"LH pulses and the corpus luteum: The luteal phase deficiency (LPD)","volume":"63","author":"Wuttke","year":"2001","journal-title":"Vitamines and Hormones"}],"container-title":["Phytomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711304702330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0944711304702330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T16:59:27Z","timestamp":1553101167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0944711304702330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0944711304702330"],"URL":"https:\/\/doi.org\/10.1078\/094471103322004866","relation":{},"ISSN":["0944-7113"],"issn-type":[{"value":"0944-7113","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}