{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:42:59Z","timestamp":1773236579582,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology - Research and Practice"],"published-print":{"date-parts":[[2003,1]]},"DOI":"10.1078\/0344-0338-00422","type":"journal-article","created":{"date-parts":[[2005,8,18]],"date-time":"2005-08-18T13:02:24Z","timestamp":1124370144000},"page":"303-311","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of Human Papillomavirus Infection, P53 and Ki-67 Expression in Cervix Cancer of Mozambican Women"],"prefix":"10.1078","volume":"199","author":[{"given":"Carla","family":"Carrilho","sequence":"first","affiliation":[]},{"given":"Patricia","family":"Gouveia","sequence":"additional","affiliation":[]},{"given":"Martha","family":"Cantel","sequence":"additional","affiliation":[]},{"given":"Matos","family":"Alberto","sequence":"additional","affiliation":[]},{"given":"Landim","family":"Buane","sequence":"additional","affiliation":[]},{"given":"Leonor","family":"David","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1078\/0344-0338-00422_bib1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1053\/paor.1999.0134","article-title":"P53 immunohistochemical expression of Egyptian cervical carcinoma","volume":"5","author":"Rye","year":"1999","journal-title":"Pathol Oncol Res"},{"key":"10.1078\/0344-0338-00422_bib2","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0959-8049(97)00161-5","article-title":"The impact of tumor angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival in squamous cervical carcinoma","volume":"33","author":"Avall-Lundgvist","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1078\/0344-0338-00422_bib3","first-page":"378","article-title":"Studies on tumor proliferation using monoclonal antibody, Ki-67 and expression of p53 in cancer of the uterine cervix","volume":"17","author":"Bar","year":"1996","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib4","first-page":"1001","article-title":"Relations between the expression of P53, c-erbB-2, ki-67 and HPV infection in cervical carcinomas and cervical dysplasias","volume":"21","author":"Bar","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1078\/0344-0338-00422_bib5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.55.4.244","article-title":"The causal relation between human papillomavirus and cervical cancer","volume":"55","author":"Bosch","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.1078\/0344-0338-00422_bib6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/jnci\/87.11.796","article-title":"International Biological Study on Cervical Cancer (IBSCC) study group: Prevalence of human papillomavirus in cervical cancer: a Worldwide perspective","volume":"87","author":"Bosch","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"10.1078\/0344-0338-00422_bib7","first-page":"415","article-title":"Human Papillomavirus and cervical intraepithelial neoplasia grade III\/carcinoma in situ: a case control study in Spain and Colombia","volume":"2","author":"Bosch","year":"1993","journal-title":"Cancer Epidemiol Biomarkers & Prev"},{"key":"10.1078\/0344-0338-00422_bib8","first-page":"4097","article-title":"Immunohistochemical detection of p53 protein in anogenital lesions and its relationship with HPV status","volume":"18","author":"Caruso","year":"1998","journal-title":"Anticancer Res"},{"key":"10.1078\/0344-0338-00422_bib9","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0140-6736(01)06523-0","article-title":"Human papillomavirus genotypes in rural Mozambique","volume":"358","author":"Castellsague","year":"2001","journal-title":"Lancet"},{"key":"10.1078\/0344-0338-00422_bib10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/jcp.50.5.413","article-title":"Relation between retinoblastoma and p53 proteins in human papilloma viruses 16\/18 positive and negative cancers of the uterine cervix","volume":"50","author":"Chetty","year":"1997","journal-title":"J Clin Pathol"},{"key":"10.1078\/0344-0338-00422_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1034\/j.1600-0463.2000.d01-46.x","article-title":"Expression of topoisomerase II and Ki-67 in cervical carcinomaclinicopathological study using immunohistochemistry","volume":"108","author":"Davidson","year":"2000","journal-title":"APMIS"},{"key":"10.1078\/0344-0338-00422_bib12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1006\/gyno.1993.1128","article-title":"c-myc protein and Ki-67 antigen immunodetection in patients with uterine cervix neoplasia: correlation of microcytophotometric analysis and histological data","volume":"49","author":"Devictor","year":"1993","journal-title":"Gynecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/gyno.1999.5715","article-title":"The possible role of p53 and bcl-2 expression in cervical carcinomas and their premalignant lesions","volume":"77","author":"Dimitrakakis","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/bjc.1994.18","article-title":"Human papillomavirus and invasive cervical cancer in Brazil","volume":"69","author":"Eluf-Neto","year":"1994","journal-title":"Br J Cancer"},{"key":"10.1078\/0344-0338-00422_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/gyno.1995.1179","article-title":"MIB 1 immunostaining in stage I squamous cervical carcinoma: relationship with natural killer cell activity","volume":"58","author":"Garzetti","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib16","first-page":"3600","article-title":"Msh2, Mlh1, Fhit, p53, Bcl-2 and Bax expression in invasive and in situ squamous cell carcinoma of the uterine cervix","volume":"6","author":"Giarnieri","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1078\/0344-0338-00422_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/path.1711710207","article-title":"Genetic alterations of the TP53 gene, p53 protein expression and HPV infection in primary cervical carcinomas","volume":"171","author":"Helland","year":"1993","journal-title":"J Pathol"},{"key":"10.1078\/0344-0338-00422_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/(SICI)1096-9896(199711)183:3<305::AID-PATH922>3.0.CO;2-F","article-title":"Correlation of MIB-1 antigen expression with transcription factors Skn-1, Oct-1, AP-2, and HPV type in cervical intraepithelial neoplasia","volume":"183","author":"Hietala","year":"1997","journal-title":"J Pathol"},{"key":"10.1078\/0344-0338-00422_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.1711690105","article-title":"Immunohistochemical analysis of p53 protein overexpression in normal, premalignant and malignant tissues of the cervix uteri","volume":"169","author":"Holm","year":"1993","journal-title":"J Pathol"},{"key":"10.1078\/0344-0338-00422_bib20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques. Acomparison between ABC and unlabeled antiboby (PAP) procedures","volume":"29","author":"Hsu","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"10.1078\/0344-0338-00422_bib21","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/gyno.2001.6397","article-title":"p53 and p21 expression in precancerous lesions and carcinomas of the uterine cervix: overexpression of p53 predicts poor disease outcome","volume":"83","author":"Huang","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib22","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1136\/jcp.49.12.971","article-title":"P53 expression in carcinoma of the cervix","volume":"49","author":"Hunt","year":"1996","journal-title":"J Clin Pathol"},{"key":"10.1078\/0344-0338-00422_bib23","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/JCM.35.3.791-795.1997","article-title":"A general primer GP5+\/GP6+\u2212mediated PCR-enzyme-immunoassay method for rapid detection of 14 high-risk and 6 lowrisk human papillomavirus genotypes in cervical scrapings","volume":"35","author":"Jacobs","year":"1997","journal-title":"J Clin Microbiol"},{"key":"10.1078\/0344-0338-00422_bib24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1096-9071(199607)49:3<223::AID-JMV11>3.0.CO;2-D","article-title":"A non-ra-dioactive PCR enzyme-immunoassay enables a rapid identification of HPV 16 and 18 in cervical scrapes after GP5+\/6+ PCR","volume":"49","author":"Jacobs","year":"1996","journal-title":"J Med Virol"},{"key":"10.1078\/0344-0338-00422_bib25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1128\/JCM.34.9.2095-2100.1996","article-title":"Use of multiple PCR primer sets for optimal detection of human papillomavirus","volume":"34","author":"Karlsen","year":"1996","journal-title":"J Clin Microbiol"},{"key":"10.1078\/0344-0338-00422_bib26","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/00000478-200107000-00006","article-title":"Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia","volume":"25","author":"Keating","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1078\/0344-0338-00422_bib27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0301-2115(01)00309-8","article-title":"Higher incidence of p53 mutation in cervical carcinomas with intermediaterisk HPV infection","volume":"98","author":"Kim","year":"2001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1078\/0344-0338-00422_bib28","first-page":"172","article-title":"Importance of study of the expression of MIB-1 (Ki-67) for diagnosis of endocervical glandular lesions","volume":"18","author":"Leteurtre","year":"1998","journal-title":"Ann Pathol"},{"key":"10.1078\/0344-0338-00422_bib29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/ijc.2910620513","article-title":"Human papillomavirus and cervical neoplasia: a case control study in Taiwan","volume":"62","author":"Liaw","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1078\/0344-0338-00422_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-2613.2001.00177.x","article-title":"Biology of human papillomaviruses","volume":"82","author":"McMurray","year":"2001","journal-title":"Int J Exp Pathol"},{"key":"10.1078\/0344-0338-00422_bib31","first-page":"30","article-title":"The presence of HPV 16, 18 and p53 immunohistochemical staining in tumor tissue of Israeli Jewish women with cervical and vulvar neoplasia","volume":"21","author":"Menczer","year":"2000","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib32","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/gyno.1995.1232","article-title":"Cervical squamous dysplasias and carcinomas with immunodetectable p53 frequently contain HPV","volume":"58","author":"Mittal","year":"1995","journal-title":"Gynecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ijc.2910520513","article-title":"The causal link between human papillomavirus and invasive cervical cancer: a population-based casecontrol study in Colombia and Spain","volume":"52","author":"Mu\u00f1oz","year":"1992","journal-title":"Int J Cancer"},{"key":"10.1078\/0344-0338-00422_bib34","first-page":"557","article-title":"Abnormal expression of pan-ras, c-myc and tp53 in squamous cell carcinoma of cervix: correlation with HPV and prognosis","volume":"8","author":"Ngan","year":"2001","journal-title":"Oncol Rep"},{"key":"10.1078\/0344-0338-00422_bib35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/ijc.2910540413","article-title":"Estimates of the worldwide frequency of eigtheen major cancers in 1985","volume":"54","author":"Parkin","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1078\/0344-0338-00422_bib36","unstructured":"MD Prates 1961 Tumores malignos na Prov\u00edncia de Mo\u00e7ambique, p126. Separata do Boletim da Sociedade de Estudos de Mo\u00e7ambique"},{"key":"10.1078\/0344-0338-00422_bib37","doi-asserted-by":"crossref","unstructured":"RE Scully, TA Bonfiglio, RJ Kurman, SG Silverberg, EJ Wilkinson (1994) World Health Organization: Histo-logical typing of the female genital tract tumors, Berlin: Springer Verlag","DOI":"10.1007\/978-3-642-85014-1"},{"key":"10.1078\/0344-0338-00422_bib38","first-page":"269","article-title":"P53 DO-1 immunohistochemical overexpression in premalignant and malignant cervical lesions","volume":"17","author":"Skopelitou","year":"1997","journal-title":"Anticancer Res"},{"key":"10.1078\/0344-0338-00422_bib39","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/jnci\/91.21.1882","article-title":"Laminin-5 as a marker of invasiveness in cervical lesions","volume":"91","author":"Skyldberg","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1078\/0344-0338-00422_bib40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/106689699700400404","article-title":"A high frequency of human papillomavirus (HPV) DNA type 16 in biopsies of cervical squamous cell neoplasia of Uygur women","volume":"4","author":"Suzuk","year":"1997","journal-title":"Int J Surg Pathol"},{"key":"10.1078\/0344-0338-00422_bib41","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ijc.2910510403","article-title":"Human papillomavirus (HPV) infection, HIV infection and cervical cancer in Tanzania, East Africa","volume":"51","author":"ter Meulen","year":"1992","journal-title":"Int J Cancer"},{"key":"10.1078\/0344-0338-00422_bib42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/humu.10178","article-title":"The role of TP53 in cervical carcinogenesis","volume":"21","author":"Tommasino","year":"2003","journal-title":"Hum Mut"},{"key":"10.1078\/0344-0338-00422_bib43","first-page":"107","article-title":"O cancro em Mo\u00e7ambique","volume":"1","author":"Torres","year":"1969","journal-title":"Influ\u00eancia dos factores mesol\u00f3gicos. Revista de Ci\u00eancias M\u00e9dicas da Universidade de Louren\u00e7o Marques"},{"key":"10.1078\/0344-0338-00422_bib44","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/ijc.2910480317","article-title":"Difference in prevalence of human papillomavirus genotypes in citomorphologically normal cervical smears is associated with a history of cervical intraepithelial neoplasia","volume":"48","author":"van den Brule","year":"1991","journal-title":"Int J Cancer"},{"key":"10.1078\/0344-0338-00422_bib45","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9%3C2011::AID-CNCR19%3E3.0.CO;2-N","article-title":"Detection and typing of human papillomavirus in cervical carcinomas in Russian women- a prognostic study","volume":"85","author":"van Muyden","year":"1999","journal-title":"Cancer"},{"key":"10.1078\/0344-0338-00422_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0020-7292(00)00248-4","article-title":"High risk HPV and p53 protein expression in cervical intraepithelial neoplasia","volume":"71","author":"Vassallo","year":"2000","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1078\/0344-0338-00422_bib47","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jmv.1890430307","article-title":"Typing of human papillomaviruses in cervical carcinoma biopsies from Cape Town","volume":"43","author":"Williamson","year":"1994","journal-title":"J Med Virol"},{"key":"10.1078\/0344-0338-00422_bib48","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0090-8258(91)90085-J","article-title":"Tumor growth fraction in cervical carcinoma","volume":"40","author":"Wong","year":"1991","journal-title":"Gynecol Oncol"},{"key":"10.1078\/0344-0338-00422_bib49","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<270::AID-PATH767>3.0.CO;2-R","article-title":"Human papillomavirus infection and invasive cervical neoplasia: a study of prevalence and morphology","volume":"181","author":"Zehbe","year":"1997","journal-title":"J Pathol"}],"container-title":["Pathology - Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033804704203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0344033804704203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T02:28:28Z","timestamp":1586399308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0344033804704203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["S0344033804704203"],"URL":"https:\/\/doi.org\/10.1078\/0344-0338-00422","relation":{},"ISSN":["0344-0338"],"issn-type":[{"value":"0344-0338","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}