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Despite years of research, no consistently effective means of prevention or treatment are readily available for cryptosporidiosis in any species. Infection through ingestion of contaminated water has been widely documented;<jats:italic>C. parvum<\/jats:italic>was reported to be responsible for the largest waterborne outbreak of infectious disease in US history. In addition to its role as a primary disease agent,<jats:italic>C. parvum<\/jats:italic>has potential to initiate or exacerbate other gastrointestinal disorders, such as inflammatory bowel disease. Thus, control of<jats:italic>C. parvum<\/jats:italic>infection in both animals and humans remains an important objective. Research in our laboratory has focused on understanding mechanisms of resistance to<jats:italic>C. parvum<\/jats:italic>. We have demonstrated that acquisition of intestinal flora increases resistance to<jats:italic>C. parvum.<\/jats:italic>Substances present in the intestinal mucosa of adult animals can transfer resistance when fed to susceptible infants. Both expression of intestinal enzymes and rate of proliferation of epithelial cells may be altered following<jats:italic>C. parvum<\/jats:italic>infection. These and other changes may have profound effects on host resistance to<jats:italic>C. parvum<\/jats:italic>.<\/jats:p>","DOI":"10.1079\/ahrr200352","type":"journal-article","created":{"date-parts":[[2003,7,15]],"date-time":"2003-07-15T22:17:23Z","timestamp":1058307443000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["<i>Cryptosporidium<\/i>and host resistance: historical perspective and some novel approaches"],"prefix":"10.1017","volume":"4","author":[{"given":"James A.","family":"Harp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,2,28]]},"reference":[{"key":"S1466252303000069_ref096","first-page":"90","article-title":"Evidence for the emergence of a type-1-like immune response in intestinal mucosa of calves recovering from cryptosporidiosis","volume":"87","author":"Wyatt","year":"2001","journal-title":"Journal of Parasitology"},{"key":"S1466252303000069_ref095","doi-asserted-by":"publisher","DOI":"10.2307\/3285762"},{"key":"S1466252303000069_ref094","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/IAI.65.1.185-190.1997","article-title":"Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum","volume":"65","author":"Wyatt","year":"1997","journal-title":"Infection and Immunity"},{"key":"S1466252303000069_ref092","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1128\/IAI.59.5.1709-1715.1991","article-title":"Regulation of gamma interferon production by natural killer cells in SCID mice: Roles of tumor necrosis factor and bacterial stimuli","volume":"59","author":"Wherry","year":"1991","journal-title":"Infection and Immunity"},{"key":"S1466252303000069_ref091","first-page":"60","article-title":"Effects of Lactobacillus reuteri on Cryptosporidium parvum infection of gnotobiotic TCR-alpha-deficient mice","volume":"46","author":"Waters","year":"1999","journal-title":"Journal of Eukaryotic Microbiology"},{"key":"S1466252303000069_ref089","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4049\/jimmunol.156.1.263","article-title":"Il-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum","volume":"156","author":"Urban","year":"1996","journal-title":"Journal of Immunology"},{"key":"S1466252303000069_ref088","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4049\/jimmunol.147.3.1014","article-title":"Cryptosporidium infection in an adult mouse model. 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