{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T01:38:05Z","timestamp":1706578685846},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":13734,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1969,8]]},"abstract":"<jats:p>1. The effect of riboflavine deficiency on liver ribonuclease activity, RNA and DNA content, and<jats:sup>32<\/jats:sup>P incorporation into RNA and DNA has been studied in rats maintained on a 16% protein diet, a protein-free diet and on a protein-free diet subsequently replaced with a 40% protein diet.<\/jats:p><jats:p>2. Rats maintained on a riboflavine-deficient diet for 45 days showed decreased incorporation of<jats:sup>32<\/jats:sup>P into liver RNA but no effect on the RNA content of liver. The concentration of DNA in liver and<jats:sup>33<\/jats:sup>P incorporation into it remained unaffected. After a deficiency period of 70 days, both the RNA and DNA contents of liver were found to be decreased. When the riboflavine-deficient or control rats were given the protein diet for 30 days and then a proteinfree diet for 15 days, the RNA content of their livers decreased, while the liver DNA content was increased. Repletion with a 40% protein diet restored the RNA and DNA content in both control and riboflavine-deficient rats.<\/jats:p><jats:p>3. Liver ribonuclease activity was decreased after a deficiency period of 45 days, whereas it was increased after a deficiency period of 70 days.<\/jats:p><jats:p>4. A correlation between liver RNA level and liver ribonuclease activity in riboflavine deficiency is suggested.<\/jats:p>","DOI":"10.1079\/bjn19690073","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"657-663","source":"Crossref","is-referenced-by-count":4,"title":["Effect of riboflavine deficiency on nucleic acid metabolism of liver in the rat"],"prefix":"10.1017","volume":"23","author":[{"given":"Ajay K.","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitabha D.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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