{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:32:35Z","timestamp":1718411555213},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":13338,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1970,9]]},"abstract":"<jats:p>1. Copper deficiency was induced in newly hatched chicks by feeding on a milk-based diet for 12 d; effects of supplementation with ascorbic acid were studied.<\/jats:p><jats:p>2. Cu deficiency alone resulted in 30% mortality from aortic rupture. This was associated with a 20% increase in total acid mucopolysaccharides in the aorta, manifested as an increase in chondroitin sulphate and a relative decrease in hyaluronic acid. Cytochrome oxidase activity of liver and heart was less than half that of the controls.<\/jats:p><jats:p>3. Supplementing the Cu-deficient diet with 0.5 % L-ascorbic acid increased mortality to 40%, raised total aortic acid mucopolysaccharides to a higher level, and increased liver iron by 36%.<\/jats:p><jats:p>4. Supplementing the control diet with ascorbic acid decreased liver Cu by 30% and significantly reduced total aortic acid mucopolysaccharides.<\/jats:p><jats:p>5. The enhancement of the Cu-deficiency effect by ascorbic acid probably results from interactions between ascorbic acid and absorption or metabolism of Cu; untoward effects of supplementing the control diet with ascorbic acid may be interpreted as manifestations of ascorbic acid toxicity<jats:italic>per se<\/jats:italic>.<\/jats:p>","DOI":"10.1079\/bjn19700062","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T23:49:52Z","timestamp":1116546592000},"page":"607-614","source":"Crossref","is-referenced-by-count":16,"title":["Copper deficiency in chicks: effects of ascorbic acid on iron, copper, cytochrome oxidase activity, and aortic mucopolysaccharides"],"prefix":"10.1017","volume":"24","author":[{"given":"C. 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