{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T05:23:00Z","timestamp":1750483380822},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,1,19]],"date-time":"2009-01-19T00:00:00Z","timestamp":1232323200000},"content-version":"unspecified","delay-in-days":13655,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1971,9]]},"abstract":"<jats:p>1. Experiments in children and in animals seem to demonstrate that in marasmic malnutrition there is a reduction in the secretion of growth hormone. To study this problem the fasting, resting plasma concentrations of growth hormone were determined, before, and 45 and 60 min after, stimulation with an intravenous dose of arginine, in six infants with marasmus, in six infants with kwashiorkor and in five normal infants.<\/jats:p><jats:p>2. The values of plasma growth hormone (4\u00b75 \u00b1 0\u00b797 ng\/ml) in marasmic infants were significantly (P &lt; 0\u00b7001) lower than those of the controls (7\u00b78 \u00b1 2\u00b76 ng\/ml), and responded little to stimulation with arginine (5\u00b71 and 5\u00b78 ng\/ml at 45 and 60 min respectively), in contrast to those in the control group, which rose to 16\u00b74 and 14\u00b76 ng\/ml. In children with kwashiorkor the values were very variable, but generally high, and showed little response (25\u00b76 \u00b1 13\u00b73 before and 25\u00b70 \u00b1 17\u00b76 and 14\u00b72 \u00b1 5\u00b73 ng\/ml at 45 and 60 min after stimulation respectively).<\/jats:p><jats:p>3. These results demonstrate that the responses of the hypophysis to deprivation of calories and protein (marasmus) and to protein deprivation (kwashiorkor) are different: in marasmus there is a progressive adaptation, with low secretion and poor reaction to stimulation, whereas in kwashiorkor the process is acute with high basal values of plasma growth hormone.<\/jats:p>","DOI":"10.1079\/bjn19710023","type":"journal-article","created":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T23:20:35Z","timestamp":1116976835000},"page":"169-175","source":"Crossref","is-referenced-by-count":27,"title":["Growth hormone in infant malnutrition: the arginine test in marasmus and kwashiorkor"],"prefix":"10.1017","volume":"26","author":[{"given":"F.","family":"Beas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maccioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,1,19]]},"reference":[{"key":"S0007114571000783_ref011","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-196801000-00005"},{"key":"S0007114571000783_ref008","first-page":"241","volume":"21","author":"Glick","year":"1965","journal-title":"Recent Prog. 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