{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:12:49Z","timestamp":1760865169546},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T00:00:00Z","timestamp":1265673600000},"content-version":"unspecified","delay-in-days":13859,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1972,3]]},"abstract":"<jats:p>1. Serum \u03b2-lipoprotein and cholesterol have been measured in children \u2018at risk\u2019 to severe protein-calorie malnutrition and in others with kwashiorkor or marasmus. \u03b2-Lipoprotein was estimated by an immunological technique. In children recovering from kwashiorkor, serum triglyceride estimations and lipoprotein electrophoretic separations were also carried out.<\/jats:p><jats:p>2. \u03b2-Lipoprotein concentrations did not fall significantly until serum albumin concentration was less than 2.5 g\/100 ml; cholesterol concentration fell before \u03b2-lipoprotein.<\/jats:p><jats:p>3. In frank kwashiorkor, serum \u03b2-lipoprotein concentration was reduced by about 30%, whereas cholesterol and triglyceride concentrations were reduced by about 50% in comparison with apparently normal children. Electrophoretic evidence showed that serum \u03b1-lipoprotein concentration was also reduced or absent altogether. Marasmic children had normal serum concentrations of \u03b2-lipoprotein and the other lipid components measured.<\/jats:p><jats:p>4. The metabolic significance of this degree of reduction in serum \u03b2-lipoprotein concentration in the pathogenesis of the fatty liver of kwashiorkor has been discussed. It was concluded that, in Ugandan children with serum albumin concentrations below 2.50 g\/100 ml, the \u03b2-lipoprotein concentration was probably insufficient for normal mobilization of fat from the liver and the children could therefore be considered susceptible to the development of a fatty liver.<\/jats:p><jats:p>5. The recovery from kwashiorkor was marked by a rapid rise in serum \u03b2-lipoprotein concentration and hypertriglyceridaemia but a slower rise in cholesterol concentration. This confirmed the results of previous investigations.<\/jats:p>","DOI":"10.1079\/bjn19720104","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"383-394","source":"Crossref","is-referenced-by-count":34,"title":["Changes in serum \u03b2-lipoprotein concentration during the development of kwashiorkor and in recovery"],"prefix":"10.1017","volume":"27","author":[{"given":"W. 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