{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:01:55Z","timestamp":1761894115536},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T00:00:00Z","timestamp":1185235200000},"content-version":"unspecified","delay-in-days":11953,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>1. The plasma concentration of retinol-binding holoprotein (holo-RBP) in rats given retinol-sufficient diets containing 50 g soya-bean protein\/kg was 90 % of the concentration found in controls given 200 g soya-bean protein\/kg, whereas in rats given 50 g rice protein\/kg it was only 68 % of the control value. Plasma albumin concentrations in the low-protein groups were lower by 20\u201325 %.<\/jats:p><jats:p>2. The rats given retinol-deficient diets, whose plasma levels of holo-RBP were reduced almost to zero after 5\u20138 weeks, were given 1\u00b75 mg retinol\/kg body-weight. Changes in plasma holo-RBP were measured for 7 d. The rapid rise in the latter to a peak above normal control levels within 1\u00b75\u20132 h indicated that a pool of the apoprotein had accumulated in the liver during the period of deficiency and that retinol was necessary for its release.<\/jats:p><jats:p>3. The maximum value reached in the groups of rats given the rice-protein diet was smaller than the values for the groups given the soya-bean-protein diets, reflecting a reduced rate of synthesis of the carrier protein in the livers of those groups.<\/jats:p><jats:p>4. The administration of 100 g casein\/kg diet to the rats receiving only 50 g rice-protein\/kg immediately stimulated the synthesis of the carrier protein which was released into plasma, reaching a peak after 24 h before settling down after 3\u20134 d to the steady-state level expected for normal well-nourished controls.<\/jats:p><jats:p>5. The half-life for excess holo-RBP released into plasma of rats receiving a normal level of good-quality protein was 7 h, where it was 14 h for the groups of low-protein diets.<\/jats:p>","DOI":"10.1079\/bjn19740108","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T23:51:57Z","timestamp":1116460317000},"page":"549-558","source":"Crossref","is-referenced-by-count":40,"title":["Effects of dietary deficiencies of protein and retinol on the plasma level of retinol-binding protein in the rat"],"prefix":"10.1017","volume":"32","author":[{"given":"H.","family":"Muhilal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Glover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,7,24]]},"reference":[{"key":"S0007114574001097_ref009","first-page":"270","volume":"40","author":"Lewin","year":"1970","journal-title":"Int. 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