{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:44:35Z","timestamp":1777981475781,"version":"3.51.4"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T00:00:00Z","timestamp":1185235200000},"content-version":"unspecified","delay-in-days":11953,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1974,11]]},"abstract":"<jats:p>1. The effects of dietary sulphur on the availability of dietary copper were estimated by means of a repletion technique. The responses of initially hypocupraemic ewes to repletion with Cu-supplemented diets containing supplements of organic S, as methionine, and of inorganic S, as Na<jats:sub>2<\/jats:sub>SO<jats:sub>4<\/jats:sub>, were compared with those obtained with a diet low in S.<\/jats:p><jats:p>2. The two forms of S had similar effects. Responses in plasma Cu were reduced by 39\u201356 % when S was increased from 1.0 to 3.0 or 4.0 g\/kg diet and the availability of dietary Cu was estimated to have decreased from 0.062 to 0.041. Both S supplements produced marked increases in rumen sulphide concentrations.<\/jats:p><jats:p>3. Dietary S had no effect on plasma Cu when added to the low-Cu diet of hypocupraemic ewes being repleted by a continuous intravenous infusion of Cu.<\/jats:p><jats:p>4. The addition of CuS, providing 5 mg Cu\/kg, to the diet of hypocupraemic ewes produced no response in plasma Cu or haemoglobin. The same amount of Cu, given as CuSO<jats:sub>4<\/jats:sub>, increased plasma Cu by 0.46\u00b10.15 mg\/l and haemoglobin by 33\u00b13.8 g\/l after 36 d: the subsequent replacement of CuSO<jats:sub>4<\/jats:sub>by CuS induced hypocupraemia again but had no effect on haemoglobin.<\/jats:p><jats:p>5. It was concluded that variations in dietary S within the normal range for herbage exert an independent effect on Cu metabolism, possibly through the formation of insoluble CuS at sites beyond the rumen.<\/jats:p>","DOI":"10.1079\/bjn19740109","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T23:51:57Z","timestamp":1116460317000},"page":"559-568","source":"Crossref","is-referenced-by-count":88,"title":["Effects of organic and inorganic sulphur on the availability of dietary copper to sheep"],"prefix":"10.1017","volume":"32","author":[{"given":"N. 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