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Retinol-deficient rats were found to have decreased body-weight, liver and testes weights, a degeneration of testicular germinal cells, an increased incorporation of labelled choline into liver and testes phospholipids, an increased protein synthetic activity (in vitro) of liver ribosomes, an increased transfer-RNA methyltransferase activity in liver and a decreased activity in testes, an increased DNA content of testicular nuclei, and a decreased uptake of [<jats:sup>3<\/jats:sup>H]thymidine by testicular nuclear DNA.<\/jats:p><jats:p>3. In retinol-deficient rats supplemented for 8 weeks with retinol these changes were reversed, measurements returning to control levels.<\/jats:p><jats:p>4. In retinol-deficient rats supplemented for 8 weeks with retinoic acid all changes were reversed except those in the testes.<\/jats:p><jats:p>5. Testicular signs of retinol deficiency appeared to be delayed when retinoic acid was added to the retinol-deficient diet of weanling rats. This suggests a sparing action of retinoic acid on the rat's utilization of retinol.<\/jats:p><jats:p>6. Suggestions are offered as to why retinoic acid will support growth and development but not spermatogenesis in the rat.<\/jats:p>","DOI":"10.1079\/bjn19750010","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T23:51:57Z","timestamp":1116460317000},"page":"73-85","source":"Crossref","is-referenced-by-count":14,"title":["The effect of retinol and retinoic acid on physiological and biochemical changes in retinol-deficient rats"],"prefix":"10.1017","volume":"33","author":[{"given":"R. F.","family":"Krause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Beamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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