{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T11:48:49Z","timestamp":1649072929640},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:00:00Z","timestamp":1206403200000},"content-version":"unspecified","delay-in-days":12017,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1975,5]]},"abstract":"<jats:p>1. Sheep fed on a maintenance ration of wheaten-hay chaff or of wheaten-hay chaff\u2013lucerne-hay chaff (1:1, w\/w) became deficient or incipiently deficient in vitamin E.<\/jats:p><jats:p>2. Degenerative changes were observed in bone marrow and muscle, and liver function was impaired in some animals. These abnormalities were not influenced by the vitamin B<jats:sub>12<\/jats:sub>status of the animals or by a shortage of cobalt in the rumen.<\/jats:p><jats:p>3. Plasma ascorbic acid levels may not have been optimum, and folic acid may not have been fully utilized by some sheep.<\/jats:p><jats:p>4. Liver function responded fairly rapidly to \u03b1-tocopheryl acetate, but skeletal muscle had not returned to normal after 28 weeks of treatment. A variable trend towards normal cellularity was found in bone marrow following supplementation with \u03b1-tocopheryl acetate.<\/jats:p><jats:p>5. A secondary deficiency or, alternatively, inefficient excretion or metabolism of a toxic material, may occur in vitamin E deficiency as a result of degenerative changes in the absorptive or excretory areas of the intestinal tract and be responsible for the bone marrow abnormality.<\/jats:p>","DOI":"10.1079\/bjn19750041","type":"journal-article","created":{"date-parts":[[2005,5,13]],"date-time":"2005-05-13T04:37:29Z","timestamp":1115959049000},"page":"357-371","source":"Crossref","is-referenced-by-count":1,"title":["An abnormality of the bone marrow associated with vitamin E deficiency in sheep"],"prefix":"10.1017","volume":"33","author":[{"given":"R. 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