{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:55:26Z","timestamp":1758635726421},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":10720,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:p>1. Fatty liver and kidney syndrome (FLKS) was induced in young broiler chickens by giving them a diet composed principally of wheat and meat meal.<\/jats:p><jats:p>2. FLKS resulted in reduced growth and increased liver weight; fasting for 18 h increased mortality, liver lipid and the specific activity of hepatic ATP-citrate lyase compared with birds fed on a commercial diet. The specific activities of hepatic fructose-l,6-diphosphate-l-phosphohydrolase and pyruvate carboxylase were reduced in birds suffering from FLKS and fasted for 18 h.<\/jats:p><jats:p>3. Feeding of the FLKS-inducing diet supplemented with 150 g animal tallow\/kg for 54 h considerably reduced mortality while restoring liver composition and enzyme activities towards those observed in birds fed a commercial diet. Investigations indicated that the glycerol component of the fat was not responsible for the observed responses.<\/jats:p><jats:p>4. The present results suggest that in FLKS insufficiencies of biotin are induced in specific enzyme systems, but the syndrome may be alleviated without the use of supplementary biotin.<\/jats:p><jats:p>5. The evidence indicates that, when stressed, birds affected by FLKS die from the hypoglycaemia occurring as a result of a reduced capacity for gluconeogenesis.<\/jats:p>","DOI":"10.1079\/bjn19770096","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"319-328","source":"Crossref","is-referenced-by-count":9,"title":["A biochemical explanation for the fatty liver and kidney syndrome of broilers: its alleviation by the short-term use of dietary fat"],"prefix":"10.1017","volume":"38","author":[{"given":"D.","family":"Balnave","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. B.","family":"Cumming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. M.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114577000440_ref018","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19760015"},{"key":"S0007114577000440_ref016","doi-asserted-by":"publisher","DOI":"10.1080\/00071667508416230"},{"key":"S0007114577000440_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(75)90039-7"},{"key":"S0007114577000440_ref020","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0034-5288(18)33637-3","volume":"18","author":"Whitehead","year":"1975","journal-title":"Res. vet. Sci."},{"key":"S0007114577000440_ref006","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0034-5288(18)33634-8","volume":"18","author":"Blair","year":"1975","journal-title":"Res. vet. Sci."},{"key":"S0007114577000440_ref010","first-page":"12P","volume":"66","author":"Huggett","year":"1957","journal-title":"Biochem. J."},{"key":"S0007114577000440_ref013","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1016\/S0021-9258(18)63531-8","volume":"244","author":"Majerus","year":"1969","journal-title":"J. biol. Chem."},{"key":"S0007114577000440_ref014","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/jn\/102.5.667","volume":"102","author":"Mason","year":"1972","journal-title":"J. Nutr."},{"key":"S0007114577000440_ref007","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0034-5288(18)33626-9","volume":"18","author":"Evans","year":"1975","journal-title":"Res. vet. Sci."},{"key":"S0007114577000440_ref017","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0034-5288(18)33627-0","volume":"18","author":"Whitehead","year":"1975","journal-title":"Res. vet. Sci."},{"key":"S0007114577000440_ref019","first-page":"70","author":"Whitehead","year":"1974","journal-title":"Proc. 15th Wld's Poult. Congr., New Orleans"},{"key":"S0007114577000440_ref005","first-page":"380","author":"Blair","year":"1974","journal-title":"Proc. 15th Wld's Poult. Congr., New Orleans"},{"key":"S0007114577000440_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114575000116"},{"key":"S0007114577000440_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0010-406X(67)90352-0"},{"key":"S0007114577000440_ref012","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0460243"},{"key":"S0007114577000440_ref011","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.1976.0028"},{"key":"S0007114577000440_ref015","doi-asserted-by":"publisher","DOI":"10.1080\/00071667408416137"},{"key":"S0007114577000440_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740261207"},{"key":"S0007114577000440_ref004","doi-asserted-by":"publisher","DOI":"10.1080\/00071667608416319"},{"key":"S0007114577000440_ref008","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"Folch","year":"1957","journal-title":"J. biol. Chem."}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114577000440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T19:15:51Z","timestamp":1626549351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114577000440\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,11]]}},"alternative-id":["S0007114577000440"],"URL":"https:\/\/doi.org\/10.1079\/bjn19770096","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,11]]}}}