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The tolerance effect against both drugs was nearly independent of the levels of B-vitamins in the diets.<\/jats:p><jats:p>4. In preparations from vitamin-B deficient animals the activities of the following hepatic microsomal enzymes were reduced: the aliphatic hydroxylase of PB, the aromatic hydroxylases of aniline (<jats:italic>EC<\/jats:italic>1.14.14.1) and of Zz, the<jats:italic>N<\/jats:italic>-demethylase of aminopyrine, the UDP glucuronyltransferase (<jats:italic>EC<\/jats:italic>2.4.1.17) of<jats:italic>p<\/jats:italic>-nitrophenol. The reactions most influenced were those of \u2018type-1\u2019 substrates, particularly those involving the hydroxylases.<\/jats:p><jats:p>5. The effects observed were caused mainly by deficiency of riboflavin and to a lesser extent of thiamin or pyridoxine.<\/jats:p>","DOI":"10.1079\/bjn19780019","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"127-137","source":"Crossref","is-referenced-by-count":6,"title":["The B-vitamin group and the activity of hepatic microsomal mixed-function oxidases of the growing Wistar rat"],"prefix":"10.1017","volume":"39","author":[{"given":"R.","family":"Miltenberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Oltersdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,7,24]]},"reference":[{"key":"S0007114578001014_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(63)90132-1"},{"key":"S0007114578001014_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(75)90121-5"},{"key":"S0007114578001014_ref012","first-page":"172","volume":"159","author":"Gram","year":"1968","journal-title":"J. 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