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Scanning electron microscope studies of the three types of gallstone observed in the gallbladders of vitamin C-deficient animals showed them to be composed of randomly-arranged needle-shaped or laminated crystals of cholesterol.<\/jats:p><jats:p>3. The hepatic bile of gallstone-forming animals had a higher cholesterol concentration and lower bile acid content, the latter being principally due to a reduction in the chenodeoxycholic fraction, than the bile of vitamin C-replete animals.<\/jats:p><jats:p>4. No significant difference was observed between the volume of bile secreted by hypovitaminotic C and vitamin C-replete animals, but due to the qualitative changes in bile composition, gallstone formation was associated with an increased biliary secretion of cholesterol and a reduced secretion of bile acids.<\/jats:p>","DOI":"10.1079\/bjn19780128","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"317-322","source":"Crossref","is-referenced-by-count":25,"title":["Biliary lipids, bile acids and gallstone formation in hypovitaminotic C guinea-pigs"],"prefix":"10.1017","volume":"40","author":[{"given":"S. A.","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114578000446_ref004","first-page":"281","volume":"87","author":"Coyne","year":"1976","journal-title":"J. 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