{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T15:11:15Z","timestamp":1648912275982},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":9990,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:p>1. Plasma tyrosine and urinary <jats:italic>p<\/jats:italic>-hydroxyphenyl lactic acid (PHPLA) and <jats:italic>p<\/jats:italic>-hydroxyphenyl acetic acid (PHPAA) were studied in thirty patients with marasmus and twenty normal controls in the same age group.<\/jats:p><jats:p>2. In the control group conventional tyrosyluria was not observed but 30% of the group excreted high levels of PHPAA. In the group with marasmus, plasma tyrosine and urinary PHPLA and PHPAA values were significantly higher than the control values. However only 13.3% of the patients were considered to have conventional tyrosyluria and 52.3% were found to excrete high levels of PHPAA.<\/jats:p><jats:p>3. Administration of ascorbic acid resulted in a reduction of PHPLA excretion while it had no effect on PHPAA excretion.<\/jats:p><jats:p>4. It was inferred that (<jats:italic>a<\/jats:italic>) tyrosyluria in marasmus is due to the reduced activity of the hepatic enzyme 4-hydroxyphenyl pyruvate: oxygen oxidoreductase (hydroxylating, decarboxylating) (PHPPA-oxidase; <jats:italic>EC<\/jats:italic> 1. 13. 11. 27) due to the deficiency of ascorbic acid and (<jats:italic>b<\/jats:italic>) high excretion of PHPAA is related to age and nutrition of the child and is unaffected by the administration of ascorbic acid.<\/jats:p><jats:p>5. It was further inferred that urinary excretion of PHPLA is a reliable index of tyrosyluria.<\/jats:p>","DOI":"10.1079\/bjn19790128","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"387-390","source":"Crossref","is-referenced-by-count":0,"title":["Tyrosyluria in marasmus"],"prefix":"10.1017","volume":"42","author":[{"given":"P. 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