{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T23:57:09Z","timestamp":1771891029229,"version":"3.50.1"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2008,2,25]],"date-time":"2008-02-25T00:00:00Z","timestamp":1203897600000},"content-version":"unspecified","delay-in-days":10282,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:p>1. A technique is described for the measurement of the extent of<jats:sup>65<\/jats:sup>Zn absorption by different regions of the intestine in the intact rat. Using this technique it was shown that the duodenum contributed 60%, the ileum 30% and the jejunum 10% to the over-all absorption of<jats:sup>65<\/jats:sup>Zn. Negligible absorption of<jats:sup>65<\/jats:sup>Zn occurred from the caecum and colon.<\/jats:p><jats:p>2. Using ligated loops of rat duodenum<jats:italic>in situ<\/jats:italic>,<jats:sup>65<\/jats:sup>Zn absorption was shown to be rapid, with 1% of a 5 \u03bcg dose being transferred to the carcase within 1 min of intraluminal dosing.<\/jats:p><jats:p>3. When<jats:sup>65<\/jats:sup>Zn was injected into ligated loops in a dose range of 1\u2013200 \u03bcg Zn\/ml the rate of absorpion was linear with respect to time over the first 15 min. The rates of<jats:sup>65<\/jats:sup>Zn absorption<jats:italic>v.<\/jats:italic>dose of<jats:sup>65<\/jats:sup>Zn exhibited saturation kinetics indicating absorpion by a \u2018carrier\u2019 or enzyme-mediated process.<\/jats:p><jats:p>4. The binding of<jats:sup>65<\/jats:sup>Zn to loop tissue showed biphasic kinetics which suggested that at low intraluminal concentrations of Zn (1\u201350 \u03bcg Zn\/ml) binding was to specific sites whereas, at higher concentrations (50\u2013200 \u03bcg Zn\/ml), non-specific binding occurred.<\/jats:p><jats:p>5. A study of the fate of mucosally bound<jats:sup>65<\/jats:sup>Zn showed that over the first 30 min a proportion of the<jats:sup>65<\/jats:sup>Zn was rapidly transferred to the carcase and this was probably associated with the rapid phase of<jats:sup>65<\/jats:sup>Zn absorption described previously. From 30 min up to 6 h after the initial binding,<jats:sup>65<\/jats:sup>Zn was also transferred to the carcase albeit at a much slower rate indicating a slow phase of Zn absorption. A study of the kinetics of this slow phase indicated that the loss of bound<jats:sup>65<\/jats:sup>Zn to the body was a saturable process indicating an enzyme or \u2018carrier\u2019-mediated process. A comparison of the kinetics of the slow and rapid phases of<jats:sup>65<\/jats:sup>Zn absorption suggests that these processes are distinct.<\/jats:p><jats:p>6. Histological examination of mucosal tissue of loops exposed to 200 \u03bcg Zn\/ml revealed no discernable damage. Similarly, no effect was observed on either arginine or glucose uptake by isolated duodenal loops<jats:italic>in situ<\/jats:italic>, although this concentration of Zn completely abolished fluid uptake. A study of the effect of different doses of Zn showed that 50 \u03bcg Zn\/ml inhibited mucosal fluid uptake by more than 50% and 100 \u03bcg Zn\/ml by more than 90%. It was concluded that these effects were due to a specific action on the fluid-transfer process and not due to a general poisoning of the mucosa.<\/jats:p>","DOI":"10.1079\/bjn19800078","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T07:49:51Z","timestamp":1118303391000},"page":"189-203","source":"Crossref","is-referenced-by-count":92,"title":["Studies on the absorption of zinc by rat intestine"],"prefix":"10.1017","volume":"43","author":[{"given":"N. T.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,2,25]]},"reference":[{"key":"S0007114580001249_ref010","first-page":"98","author":"Evans","year":"1978","journal-title":"Proc. 3rd int. Symp. Trace Element Metabolism in Man and Animals"},{"key":"S0007114580001249_ref007","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-151-39305"},{"key":"S0007114580001249_ref020","doi-asserted-by":"publisher","DOI":"10.1042\/bj0360059"},{"key":"S0007114580001249_ref032","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-138-35851"},{"key":"S0007114580001249_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-015721-4.50015-X"},{"key":"S0007114580001249_ref039","doi-asserted-by":"publisher","DOI":"10.4141\/cjas58-016"},{"key":"S0007114580001249_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/70.1.53"},{"key":"S0007114580001249_ref018","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1152\/ajplegacy.1974.226.2.401","volume":"226","author":"Kowalski","year":"1974","journal-title":"Am. J. Physiol."},{"key":"S0007114580001249_ref003","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/ajplegacy.1962.202.2.359","volume":"202","author":"Cotzias","year":"1962","journal-title":"Am. J. Physiol."},{"key":"S0007114580001249_ref004","first-page":"57","author":"Cousins","year":"1978","journal-title":"Proc. 3rd int. Symp. Trace Element Metabolism in Man and Animals"},{"key":"S0007114580001249_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/85.4.367"},{"key":"S0007114580001249_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-015721-4.50018-5"},{"key":"S0007114580001249_ref021","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.34.1.58"},{"key":"S0007114580001249_ref009","first-page":"285","volume-title":"Advances in Experimental Medicine and Biology","author":"Evans","year":"1974"},{"key":"S0007114580001249_ref034","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/88.1.125"},{"key":"S0007114580001249_ref036","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-136-35250"},{"key":"S0007114580001249_ref035","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/97.1.104"},{"key":"S0007114580001249_ref028","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0021-9258(18)43097-9","volume":"160","author":"Somogyi","year":"1945","journal-title":"J. biol. Chem."},{"key":"S0007114580001249_ref016","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-196202000-00005"},{"key":"S0007114580001249_ref040","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19700102"},{"key":"S0007114580001249_ref012","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1152\/ajplegacy.1955.181.2.287","volume":"181","author":"Feaster","year":"1955","journal-title":"Am. J. Physiol."},{"key":"S0007114580001249_ref029","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/86.2.169"},{"key":"S0007114580001249_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(77)91041-5"},{"key":"S0007114580001249_ref031","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-137-35566"},{"key":"S0007114580001249_ref033","first-page":"217","volume-title":"Trace Elements in Human and Animal Nutrition","author":"Underwood","year":"1971"},{"key":"S0007114580001249_ref005","first-page":"46","volume":"229","author":"Davies","year":"1973","journal-title":"J. Physiol., Lond."},{"key":"S0007114580001249_ref038","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/91.4.473"},{"key":"S0007114580001249_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/86.2.120"},{"key":"S0007114580001249_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114575000293"},{"key":"S0007114580001249_ref008","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1152\/ajplegacy.1975.228.2.501","volume":"228","author":"Evans","year":"1975","journal-title":"Am. J. Physiol."},{"key":"S0007114580001249_ref019","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/85.3.230"},{"key":"S0007114580001249_ref024","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/106.11.1591"},{"key":"S0007114580001249_ref001","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-196107000-00002"},{"key":"S0007114580001249_ref027","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/108.11.1849"},{"key":"S0007114580001249_ref026","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1152\/ajplegacy.1961.200.6.1345","volume":"200","author":"Rubini","year":"1961","journal-title":"Am. J. Physiol."},{"key":"S0007114580001249_ref030","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/97.3.321"},{"key":"S0007114580001249_ref023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)71980-7","volume":"153","author":"Nelson","year":"1944","journal-title":"J. biol. Chem."},{"key":"S0007114580001249_ref011","first-page":"1142","volume":"40","author":"Evans","year":"1970","journal-title":"Res. Commun."},{"key":"S0007114580001249_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/74.3.194"},{"key":"S0007114580001249_ref022","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1973.34.1.63"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114580001249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T14:09:30Z","timestamp":1626012570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114580001249\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["S0007114580001249"],"URL":"https:\/\/doi.org\/10.1079\/bjn19800078","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}