{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:03:45Z","timestamp":1759701825673},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":9320,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:p>1. Erythrocytes (RBC) from control and marginally riboflavin-deficient subjects were fractionated into nine fractions using a discrete density gradient.<\/jats:p><jats:p>2. Glutathione reductase (NAD(P)H: glutathione oxidoreductase;<jats:italic>EC<\/jats:italic>1.6.4.2) activity and aspartate aminotransferase (<jats:italic>EC<\/jats:italic>2.6.1.1) activity (with and without the appropriate co-enzymes) reduced glutathione, methaemoglobin, sulphaemoglobin and oxyhaemoglobin and susceptibility to peroxide were measured in RBC in the different fractions.<\/jats:p><jats:p>3. Glutathione reductase and aspartate aminotransferase activities and concentrations of reduced glutathione and oxyhaemoglobin all declined with age, while melhaemoglobin, sulphaemoglobin and susceptibility to peroxide increased with age.<\/jats:p><jats:p>4. The only significant differences noted in the RBC from marginally-riboflavin-deficient subjects by comparison with controls, were lower glutathione reductase activities and higher concentrations of methaemoglobin.<\/jats:p><jats:p>5. The role of riboflavin in those sytems controlling RBC integrity is discussed.<\/jats:p>","DOI":"10.1079\/bjn19810031","type":"journal-article","created":{"date-parts":[[2005,5,18]],"date-time":"2005-05-18T23:51:57Z","timestamp":1116460317000},"page":"257-266","source":"Crossref","is-referenced-by-count":23,"title":["Riboflavin deficiency in man: effects on haemoglobin and reduced glutathione in erythrocytes of different ages"],"prefix":"10.1017","volume":"46","author":[{"given":"Hilary J.","family":"Powers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. I.","family":"Thurnham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114581001062_ref035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0009-8981(64)90210-4","volume":"10","author":"Voss","year":"1964","journal-title":"Clin. Chim. Acta"},{"key":"S0007114581001062_ref032","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0021-9258(18)81394-1","volume":"237","author":"Scott","year":"1962","journal-title":"J. biol. Chem."},{"key":"S0007114581001062_ref028","doi-asserted-by":"publisher","DOI":"10.1159\/000176144"},{"key":"S0007114581001062_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0022-5193(81)90244-7"},{"key":"S0007114581001062_ref019","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104536"},{"key":"S0007114581001062_ref010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0022-2275(20)40348-7","volume":"4","author":"Desai","year":"1963","journal-title":"J. lipid Res."},{"key":"S0007114581001062_ref009","year":"1979","journal-title":"Rep. Hlth Soc. Subj."},{"key":"S0007114581001062_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1967.tb08832.x"},{"key":"S0007114581001062_ref004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103468"},{"key":"S0007114581001062_ref022","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0021-9258(18)55529-0","volume":"198","author":"Krimsky","year":"1952","journal-title":"J. biol. Chem."},{"key":"S0007114581001062_ref003","doi-asserted-by":"publisher","DOI":"10.1038\/226759a0"},{"key":"S0007114581001062_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90080-1"},{"key":"S0007114581001062_ref012","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0021-9258(18)73873-8","volume":"126","author":"Evelyn","year":"1938","journal-title":"J. biol. Chem."},{"key":"S0007114581001062_ref014","volume":"23","author":"Goldstein","year":"1975","journal-title":"Clin. Res."},{"key":"S0007114581001062_ref008","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/blood.V12.12.1132.1132","volume":"12","author":"Crosby","year":"1957","journal-title":"Blood"},{"key":"S0007114581001062_ref024","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.3.373"},{"key":"S0007114581001062_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.3.363"},{"key":"S0007114581001062_ref017","first-page":"349","volume":"47","author":"Hassan","year":"1977","journal-title":"Int. Z. Vitaminforsch."},{"key":"S0007114581001062_ref007","doi-asserted-by":"publisher","DOI":"10.1021\/bi00906a038"},{"key":"S0007114581001062_ref002","first-page":"882","volume":"61","author":"Beutler","year":"1963","journal-title":"J. lab. clin. Med."},{"key":"S0007114581001062_ref027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb03621.x"},{"key":"S0007114581001062_ref001","first-page":"49","volume":"7","author":"Alfrey","year":"1970","journal-title":"Semin. Haematol."},{"key":"S0007114581001062_ref030","doi-asserted-by":"publisher","DOI":"10.1042\/bst0080195"},{"key":"S0007114581001062_ref029","volume":"39","author":"Powers","year":"1980","journal-title":"Proc. Nutr. Soc."},{"key":"S0007114581001062_ref033","unstructured":"Thurnham D. I. & Stephen J. M. L. (1975). Xth Int. Cong. Nutr. Kyoto, 1975 Abstr. 6304 p. 303."},{"key":"S0007114581001062_ref036","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.25.11.940"},{"key":"S0007114581001062_ref025","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/108.1.145"},{"key":"S0007114581001062_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/105.11.1481"},{"key":"S0007114581001062_ref005","first-page":"905","volume":"59","author":"Brewer","year":"1962","journal-title":"J. lab. clin. Med."},{"key":"S0007114581001062_ref011","doi-asserted-by":"publisher","DOI":"10.1042\/bj0840286"},{"key":"S0007114581001062_ref015","first-page":"187","volume":"13","author":"Gross","year":"1976","journal-title":"Semin. Heamatol."},{"key":"S0007114581001062_ref020","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103934"},{"key":"S0007114581001062_ref021","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050180034008a"},{"key":"S0007114581001062_ref013","first-page":"739","volume":"78","author":"Fischer","year":"1971","journal-title":"J. lab. clin. Med."},{"key":"S0007114581001062_ref016","unstructured":"Hassan F. M. (1978). Erythrocyte pathophysiology of riboflavin deficiency in rats. PhD Thesis, University of London."},{"key":"S0007114581001062_ref018","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104889"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114581001062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T02:20:28Z","timestamp":1625970028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114581001062\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,9]]}},"alternative-id":["S0007114581001062"],"URL":"https:\/\/doi.org\/10.1079\/bjn19810031","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}