{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:28:16Z","timestamp":1764782896279},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T00:00:00Z","timestamp":1244073600000},"content-version":"unspecified","delay-in-days":9896,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:p>1. Utilizing the bromodeoxyuridine differential-chromatid labelling technique the in vitro proliferation of lymphocytes from children with kwashiorkor was followed in phytohaemagglutinin-stimulated cultures and compared with controls.<\/jats:p><jats:p>2. Analyses of first, second and third or subsequent division cells as a function of culture time between 40 and 96 h showed that cell-cycle duration was prolonged in kwashiorkor cultures. The extent of this increase was approximately 4.5 h for the first-division cells and 1.5 h for third-division cells.<\/jats:p><jats:p>3. The peak for second-division cells was depressed in kwashiorkor cultures.<\/jats:p><jats:p>4. A decreased number of third or subsequent-division cells was observed in kwashiorkor cultures at all time points studied.<\/jats:p><jats:p>5. These findings suggest that the loss in lymphocyte activity to PHA in malnourished children in general could be due to an increase in cell-cycle duration of responding lymphocytes.<\/jats:p>","DOI":"10.1079\/bjn19820056","type":"journal-article","created":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T23:20:35Z","timestamp":1116976835000},"page":"445-450","source":"Crossref","is-referenced-by-count":10,"title":["Lymphocyte proliferation kinetics in malnourished children measured by differential chromatid staining"],"prefix":"10.1017","volume":"47","author":[{"given":"P. Balakrishna","family":"Murthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Abdul","family":"Rahiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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