{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:41:52Z","timestamp":1773420112191,"version":"3.50.1"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,7,24]],"date-time":"2007-07-24T00:00:00Z","timestamp":1185235200000},"content-version":"unspecified","delay-in-days":8666,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:p>1. Studies of anaemia and tissue iron distribution were carried out in copper-deficient rats and pair-fed control animals given Fe orally or parenterally in varying doses.<\/jats:p><jats:p>2. The anaemia of Cu deficiency was partially but incompletely corrected by oral Fe supplementation of one-to five-fold normal dietary levels or by intramuscular Fe supplementation.<\/jats:p><jats:p>3. Serum Fe increased in Cu-deficient animals as the dose of supplemental Fe was increased.<\/jats:p><jats:p>4. Hepatic Fe accumulation occurred in Cu-deficient rats which were administered with either oral Fe in two-to five-fold excess or low doses of intramuscular Fe. This difference was not seen in animals receiving high doses of intramuscular Fe, but similar relativedifferences were seen in Cu-deficient and Cu-replete rats which had been given no Fe supplementation.<\/jats:p><jats:p>5. Duodenal Fe was not increased in Cu deficiency. Bone marrow Fe was present in Cu-deficient animals receiving either parenteral or oral Fe supplementation.<\/jats:p><jats:p>6. Present studies suggest that a decrease in caeruloplasmin (<jats:italic>EC<\/jats:italic>1. 16. 3. 1) activity does not wholly explain the anaemia of Cu deficiency.Fe accumulation may be restricted to the liver, suggesting that Cu may be required for normal intracellular Fe metabolism.<\/jats:p>","DOI":"10.1079\/bjn19830136","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:09:04Z","timestamp":1118513344000},"page":"653-660","source":"Crossref","is-referenced-by-count":62,"title":["Hepatic iron accumulation in copper-deficient rats"],"prefix":"10.1017","volume":"50","author":[{"given":"Darryl M.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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