{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:56:20Z","timestamp":1761742580004},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":8347,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p>1. Newborn rabbits were over-fed by encouraging them to suck from two lactating does. These double-fed animals were compared with single-fed litter-mate controls.<\/jats:p><jats:p>2. Single- and double-fed rabbits were compared with respect to body-weight, bone length and weights of heart, kidney, lung, liver, spleen, stomach, brain and adipose lobes at ages 7, 14 and 21 d and at 25 weeks. Body composition with respect to fat, protein and water was also analysed in animals killed during the first month of life.<\/jats:p><jats:p>3. Double feeding had a profound effect on body-weight, such that by 21 d of age these animals weighed 65% more than controls. Longitudinal growth was also increased, but to a lesser extent. Organ weights were largely determined by body-weight with the exception of the brain which was unaffected by double feeding and the heart and adipose lobes which were represented to excess. Body composition studies demonstrated a marked increase in body fat and a decrease in body water as a percentage of body-weight in the double-fed.<\/jats:p><jats:p>4. When mature, double-fed rabbits weighed a little more than controls and had accumulated significantly more fat. No other difference between them was demonstrated.<\/jats:p><jats:p>5. Other experiments on rats, mice and pigs, along with these experiments on rabbits, suggest that young mammals respond to over-feeding with a limited increase in real growth associated with excess deposition of adipose tissue. Studies on infants of diabetic mothers have demonstrated that the human fetus responds to over-nutrition in a very similar way. Therefore we should be cautious about over-feeding human infants, especially premature ones, as it seems unlikely that excessive deposition of fat will be beneficial.<\/jats:p>","DOI":"10.1079\/bjn19840045","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T23:49:52Z","timestamp":1116546592000},"page":"389-402","source":"Crossref","is-referenced-by-count":12,"title":["The effect of over-feeding newborn rabbits on somatic and visceral growth, body composition and long-term growth potential"],"prefix":"10.1017","volume":"51","author":[{"given":"S. Andrew","family":"Spencer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114584000465_ref026","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1963.0051"},{"key":"S0007114584000465_ref023","first-page":"330","volume-title":"Scientific Foundations of Paediatrics","author":"Widdowson","year":"1981"},{"key":"S0007114584000465_ref008","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.233.36"},{"key":"S0007114584000465_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(79)90022-7"},{"key":"S0007114584000465_ref010","doi-asserted-by":"publisher","DOI":"10.1159\/000240288"},{"key":"S0007114584000465_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/adc.48.10.757"},{"key":"S0007114584000465_ref025","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1960.0032"},{"key":"S0007114584000465_ref011","doi-asserted-by":"publisher","DOI":"10.1159\/000240527"},{"key":"S0007114584000465_ref013","first-page":"1079","volume":"33","author":"Khermosh","year":"1972","journal-title":"American Journal of Veterinary Research"},{"key":"S0007114584000465_ref021","first-page":"576","volume":"290","author":"Verdy","year":"1974","journal-title":"New England Journal of Medicine"},{"key":"S0007114584000465_ref018","first-page":"123","volume-title":"The Pregnant Diabetic and Her Newborn","author":"Pedersen","year":"1977"},{"key":"S0007114584000465_ref001","doi-asserted-by":"crossref","first-page":"268","DOI":"10.5694\/j.1326-5377.1966.tb19702.x","volume":"1","author":"Breidahl","year":"1966","journal-title":"Medical Journal of Australia"},{"key":"S0007114584000465_ref019","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19810052"},{"key":"S0007114584000465_ref004","first-page":"744","volume-title":"Scientific Foundations of Paediatrics","author":"Dobbing","year":"1981"},{"key":"S0007114584000465_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb15808.x"},{"key":"S0007114584000465_ref012","first-page":"xix","volume":"15","author":"Kennedy","year":"1957","journal-title":"Journal of Endocrinology"},{"key":"S0007114584000465_ref016","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1530\/acta.0.0160330","volume":"16","author":"Pedersen","year":"1954","journal-title":"Acta Endocrinologica"},{"key":"S0007114584000465_ref017","first-page":"211","volume-title":"The Pregnant Diabetic and Her Newborn","author":"Pedersen","year":"1977"},{"key":"S0007114584000465_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)34963-X"},{"key":"S0007114584000465_ref002","volume-title":"British Paediatric Association, 55th Annual Meeting","author":"Calvert","year":"1983"},{"key":"S0007114584000465_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1953.tb07282.x"},{"key":"S0007114584000465_ref024","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19550043"},{"key":"S0007114584000465_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1960.04020040820004"},{"key":"S0007114584000465_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90499-3"},{"key":"S0007114584000465_ref020","first-page":"48A","volume":"38","author":"Stanier","year":"1979","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114584000465_ref014","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1096731"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114584000465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T11:11:53Z","timestamp":1586257913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114584000465\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["S0007114584000465"],"URL":"https:\/\/doi.org\/10.1079\/bjn19840045","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}