{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:40:43Z","timestamp":1756896043324},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":8224,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1984,9]]},"abstract":"<jats:p>1. The possibility that viscous polysaccharides, such as guar gum, could lower post-prandial blood glucose levels in part by restricting carbohydrate solutions to a smaller area of small intestine was investigated in twenty healthy human volunteers.<\/jats:p><jats:p>2. Addition of guar gum (22.5 g\/l) delayed the mouth-to-caecum transit time of a hypotonic lactulose drink, but did not affect gastric emptying.<\/jats:p><jats:p>3. When a 250 ml solution containing 50 g glucose was confined to a 550 mm length of intestine by an occluding balloon attached to an intestinal tube, maximum blood glucose response was significantly reduced (P &lt; 0.05) though only by 0.9 mmol\/l.<\/jats:p><jats:p>4. Addition of guar gum (36 g\/l) had no effect on the distribution of a radio-labelled glucose drink (250 ml; 200 g glucose\/l) in the small intestine, monitored using a gamma camera, although it significantly delayed gastric emptying (t<jats:sub>\u00bd<\/jats:sub> (min): guar gum v. control 115 (SE 15) v. 73 (SE 8)).<\/jats:p><jats:p>5. Reduced contact area is unlikely to be one of the mechanisms by which guar gum improves glucose tolerance.<\/jats:p>","DOI":"10.1079\/bjn19840088","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T03:49:51Z","timestamp":1118288991000},"page":"197-204","source":"Crossref","is-referenced-by-count":54,"title":["Does guar gum improve post-prandial hyperglycaemia in humans by reducing small intestinal contact area?"],"prefix":"10.1017","volume":"52","author":[{"given":"N. A.","family":"Blackburn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Holgate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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