{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:04:49Z","timestamp":1770966289068,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"unspecified","delay-in-days":8466,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p>1. Unfractionated gliadin and its \u03b1-, \u03b2-, \u03b3- and \u03c9-gliadin subfractions were used as rabbit immunogens. The antisera were characterized by (1) Ouchterlony double diffusion, (2) binding of <jats:sub>125<\/jats:sub>I-labelled gliadin subfractions, (3) inhibition by several gliadin subfractions of binding between \u03b3gliadin antiserum and <jats:sub>125<\/jats:sub>I-labeIled \u03b3gliadin.<\/jats:p><jats:p>2. Double diffusion showed identical cross-reactivity between the antisera and the gliadin subfractions with the exception of \u03c9-gliadin. Precipitin lines of partial identity with gliadin were observed against rye secalins and barley hordeins but not oat avenins or maize zeins.<\/jats:p><jats:p>3. Binding was observed between unfractionated <jats:sub>125<\/jats:sub>I-labelled\u03b1-, \u03b2-, \u03b3- and \u03c9-gliadins and all the antisera. There was binding of <jats:sub>125<\/jats:sub>I-labelled \u03c9-gliadin to the \u03c9-gliadin antiserum but poor binding of <jats:sub>125<\/jats:sub>I-labelled \u03c9-gliadin to unfractionated \u03b1-, \u03b2- and \u03b3-gliadin antisera. Competitive inhibition of binding between <jats:sub>125<\/jats:sub>I-labelled \u03b3-gliadin and \u03b3-gliadin antiserum diluted 1:250 (v\/v) demonstrated similar competition between \u03b1-, \u03b2- and \u03b3-gliadins and this antiserum but poor competition between \u03c9-gliadin, wheat glutenins, albumins and globulins, rye secalins, barley hordeins and oat avenins.<\/jats:p><jats:p>4. These findings suggest that there is a good correlation between the antigenic structure of gliadin proteins and their toxicity to patients with coeliac disease.<\/jats:p>","DOI":"10.1079\/bjn19850008","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"39-45","source":"Crossref","is-referenced-by-count":19,"title":["Relation of antigenic structure of cereal proteins to their toxicity in coeliac patients"],"prefix":"10.1017","volume":"53","author":[{"given":"P. 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S.","family":"Lennox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,3,7]]},"reference":[{"key":"S0007114585001751_ref011","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740241011"},{"key":"S0007114585001751_ref010","first-page":"201","volume-title":"Food Nutrition and Evolution: Food as an Environmental Factor in the Genesis of Human Variability","author":"Kasarda","year":"1981"},{"key":"S0007114585001751_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90339-4"},{"key":"S0007114585001751_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/194495a0"},{"key":"S0007114585001751_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05563.x"},{"key":"S0007114585001751_ref009","first-page":"75","volume-title":"Perspectives in Coeliac Disease","author":"Jos","year":"1978"},{"key":"S0007114585001751_ref003","doi-asserted-by":"publisher","DOI":"10.1042\/cs0640655"},{"key":"S0007114585001751_ref012","first-page":"67","volume-title":"Intestinal Biopsy, CIBA Foundation Study Group","author":"Rubin","year":"1962"},{"key":"S0007114585001751_ref005","first-page":"750","volume":"14","author":"Ewart","year":"1966","journal-title":"Journal of the Science of Food and Agriculture"},{"key":"S0007114585001751_ref001","first-page":"101","volume":"183","author":"Anand","year":"1978","journal-title":"Quarterly Journal of Medicine"},{"key":"S0007114585001751_ref002","doi-asserted-by":"publisher","DOI":"10.1042\/cs0660357"},{"key":"S0007114585001751_ref006","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.1984.12005681"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114585001751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T23:42:09Z","timestamp":1558568529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114585001751\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["S0007114585001751"],"URL":"https:\/\/doi.org\/10.1079\/bjn19850008","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}