{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T08:50:32Z","timestamp":1779180632659,"version":"3.51.4"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":7556,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>1. Female weanling rats were fed on a purified diet containing either no vitamin A, apart from traces present in casein (deficient groups), or the same diet containing 1.55 mg retinol as retinyl acetate\/kg (control groups). In one experiment the deficient groups were given 1 \u03bcg retinol\/d after 10 weeks, to permit successful reproduction under conditions of marginal vitamin A status. A proportion were mated at 11 weeks after weaning, and fetal development was permitted for 7 d or for 20 d before killing.<\/jats:p><jats:p>2. Carotene dioxygenase (<jats:italic>EC<\/jats:italic>1. 13.11.21) activity was measured in a supernatant fraction from intestinal mucosal scrapings. For each group, activity was 20\u201330% greater in the vitamin-A-deficient animals than in the controls, and the difference reached statistical significance for the virgin and 7 d pregnant animals in the first experiment (severe deficiency) and for the 20 d pregnant animals in the second experiment (less-severe deficiency).<\/jats:p><jats:p>3. It is suggested that low tissue vitamin A levels may feedback to increase carotene dioxygenase activity, by mechanisms at present unknown, presumably to ensure a more efficient use of precursor dietary carotenoids.<\/jats:p>","DOI":"10.1079\/bjn19860091","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"115-122","source":"Crossref","is-referenced-by-count":50,"title":["Carotene dioxygenase (<i>EC<\/i>1. 13. 11. 21) activity in rat intestine: effects of vitamin A deficiency and of pregnancy"],"prefix":"10.1017","volume":"56","author":[{"given":"Laurence","family":"Villard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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