{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:55:51Z","timestamp":1785545751783,"version":"3.56.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":7313,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>1. It was demonstrated that the development of experimental avitaminosis A in chicks led to secondary zinc deficiency. The balance of Zn in the chick became negative, while the Zn content of various tissues decreased. Thus in vitamin-A-deficient chicks the serum Zn content was 1258 (SD 26.3) \u03bcg\/l which was considerably lower than 1652 (SD 97.8) \u03bcg\/l in controls.<\/jats:p><jats:p>2. Zn absorption was considerably reduced throughout the entire small intestine of vitamin-A-deficient chicks and most markedly in the ileal region. Within 72 h after retinyl acetate administration Zn absorption was fully restored in this region of the intestine.<\/jats:p><jats:p>3. The<jats:sup>65<\/jats:sup>Zn-binding capacity of soluble proteins, present in the supernatant fraction of ileal-mucosa homogenates of vitamin-A-deficient chicks, was found to increase 2.6 times by 72 h after the administration of a single dose of retinyl acetate.<\/jats:p><jats:p>4. A vitamin-A-dependent Zn-binding protein (ZnBP), absent in vitamin-A-deficient chicks, was isolated from the ileal mucosa after their repletion with vitamin A. Competitive-binding studies (calcium, cadmium, copper) showed the protein to be highly specific for Zn ions.<\/jats:p><jats:p>5. The molecular weight of ZnBP wa5 83 kDa. The association constant of the protein-Zn complex was 0.8 x 10<jats:sup>6<\/jats:sup>\/mol. The protein was acidic with approximately 20% of its amino acid residues belonging to dicarboxylic acids. ZnBP was found to be a glycoprotein, and it contained hexose as a carbohydrate component.<\/jats:p><jats:p>6. It is suggested that ZnBP is involved in the binding of Zn in the ileal mucosa of chicks.<\/jats:p>","DOI":"10.1079\/bjn19870031","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"255-268","source":"Crossref","is-referenced-by-count":23,"title":["Vitamin-A-dependent zinc-binding protein and intestinal absorption of Zn in chicks"],"prefix":"10.1017","volume":"57","author":[{"given":"Nadezhda I.","family":"Berzin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria 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