{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:52:02Z","timestamp":1648677122986},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6460,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:p>Female C57BL mice heterozygous for the brindled gene were mated to normal males and fed on a purified diet low in copper throughout gestation and lactation with (+ Cu) or without (\u2212Cu) Cu-supplemented drinking water. Male offspring of two genotypes (control, + \/y and brindled, Mo<jats:sup>br<\/jats:sup>\/y) were compared when 10\u201312 d old. Brindled mice from dams on the \u2013 Cu treatment were smaller and had lower packed cell volumes than brindled mice from dams on the + Cu treatment. The \u2212Cu brindled mice were smaller than their littermate brothers (+\/y) but had equivalent biochemical features consistent with severe Cu deficiency. Compared with control mice from dams on the +Cu treatment, caeruloplasmin (<jats:italic>EC<\/jats:italic>1.16.3.1) activity was lower in offspring of all three other groups including Mo<jats:sup>br<\/jats:sup>\/y mice who were not anaemic. Iron levels were similar in organs and bone marrow from all four groups of offspring. When dietary Cu is limiting in brindled mice a more severe Cu deficiency ensues. Thus, appropriate Cu nutriture is important to the management of Menkes' disease in humans, a genetic analogue of the brindled mouse.<\/jats:p>","DOI":"10.1079\/bjn19890017","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"177-184","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dietary copper deficiency on male offspring of heterozygous brindled mice"],"prefix":"10.1017","volume":"62","author":[{"given":"Joseph R.","family":"Prohaska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114589001005_ref034","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.6.575"},{"key":"S0007114589001005_ref033","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood.V48.1.77.77","article-title":"Role of copper in mitochondrial iron metabolism","volume":"48","author":"Williams","year":"1976","journal-title":"Blood"},{"key":"S0007114589001005_ref032","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.1.1"},{"key":"S0007114589001005_ref031","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19870122"},{"key":"S0007114589001005_ref029","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106460"},{"key":"S0007114589001005_ref028","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/112.9.1706"},{"key":"S0007114589001005_ref022","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.10.2048"},{"key":"S0007114589001005_ref019","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/S0021-9258(18)96527-0","article-title":"The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum","volume":"241","author":"Osaki","year":"1966","journal-title":"Journal of Biological Chemistry"},{"key":"S0007114589001005_ref018","volume-title":"Biological Roles of Copper","author":"Mills","year":"1980"},{"key":"S0007114589001005_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(87)80190-2"},{"key":"S0007114589001005_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/116.7.1225"},{"key":"S0007114589001005_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/249852a0"},{"key":"S0007114589001005_ref011","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-186-42600"},{"key":"S0007114589001005_ref010","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/39.2.289"},{"key":"S0007114589001005_ref025","volume-title":"Essential and Toxic Trace Elements in Human Health and Disease","author":"Prohaska","year":"1988"},{"key":"S0007114589001005_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/103.2.196"},{"key":"S0007114589001005_ref008","first-page":"480","article-title":"Das kinky-hair-syndrom von Menkes","volume":"185","author":"Dorn","year":"1973","journal-title":"Klinische P\u00e4diatrie"},{"key":"S0007114589001005_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07184.x"},{"key":"S0007114589001005_ref007","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.08.070188.001315"},{"key":"S0007114589001005_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.7.1340"},{"key":"S0007114589001005_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/114.2.422"},{"key":"S0007114589001005_ref016","doi-asserted-by":"publisher","DOI":"10.1042\/bj1860629"},{"key":"S0007114589001005_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90586-9"},{"key":"S0007114589001005_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(81)80098-X"},{"key":"S0007114589001005_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.5.633"},{"key":"S0007114589001005_ref004","doi-asserted-by":"publisher","DOI":"10.1084\/jem.103.5.701"},{"key":"S0007114589001005_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/S0271-5317(88)80063-0"},{"key":"S0007114589001005_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(72)80018-3"},{"key":"S0007114589001005_ref024","first-page":"87","article-title":"Genetic diseases of copper metabolism","volume":"4","author":"Prohaska","year":"1986","journal-title":"Clinical Physiology and Biochemistry"},{"key":"S0007114589001005_ref005","doi-asserted-by":"publisher","DOI":"10.1042\/bj1800597"},{"key":"S0007114589001005_ref027","doi-asserted-by":"publisher","DOI":"10.1126\/science.7244654"},{"key":"S0007114589001005_ref020","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1016\/S0021-9258(18)62284-7","article-title":"The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase","volume":"246","author":"Osaki","year":"1971","journal-title":"I. 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