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Brains from thiamin-deficient animals contained less glutamate, 2-oxo-glutarate and GABA than those from control animals. The brain content of ATP was unaffected by thiamin deficiency. After intracerebroventricular injection of [<jats:sup>14<\/jats:sup>C]glutamate, the specific radioactivity of GABA in the brains from deficient animals was 45\u201350% higher than that in controls, suggesting a considerable increase in the metabolic flux through the GABA shunt in thiamin deficiency. Brain GABA showed a marked circumannual variation, with a peak in mid-summer and a minimum value in mid-winter.<\/jats:p>","DOI":"10.1079\/bjn19890027","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"245-253","source":"Crossref","is-referenced-by-count":20,"title":["Brain glutamate and \u03b3-aminobutyrate (GABA) metabolism in thiamin-deficient rats"],"prefix":"10.1017","volume":"62","author":[{"given":"Martyn G.","family":"Page","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Ankoma-Sey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Coulson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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