{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:57:16Z","timestamp":1761742636662},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6582,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:p>1. Rats fed on a protein-depleted diet for 8 weeks were repleted for 5 weeks on high-protein (HP), high-protein+20 g DL-carnitine\/kg (HP +C), or low-protein + 20 g DL-carnitine\/kg (LP +C) diets. At 4 and 8 weeks of depletion, and 1 and 5 weeks of repletion, rats from each treatment group were given a benzoic acid tolerance test (BATT) or a cinnamic acid tolerance test (CATT) as a measure of liver function.<\/jats:p><jats:p>2. BATT and CATT measured the molar percentage of a test dose (1 mmol\/kg body-weight) of benzoic acid or cinnamic acid excreted in the urine as hippuric acid within 24 h. Liver weight, liver lipid levels, and carnitine concentration in plasma and liver were also measured following liver-function testing.<\/jats:p><jats:p>3. BATT and CATT were severely impaired in protein-depleted rats, but returned rapidly to control levels following protein refeeding. Correlations of BATT and CATT with liver lipid concentration were high (<jats:italic>r<\/jats:italic>-0.49 and -0.62 respectively), and both tests show promise as clinical tests for liver function in protein-energy malnutrition.<\/jats:p><jats:p>4. Carnitine supplementation was required to return liver carnitine concentration of protein-depleted rats to control levels during repletion, but was not associated with accelerated reduction in liver fat concentration in protein-repleted rats.<\/jats:p>","DOI":"10.1079\/bjn19890110","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"209-221","source":"Crossref","is-referenced-by-count":16,"title":["Liver function in protein-energy malnutrition measured by cinnamic acid tolerance and benzoic acid tolerance: effect of carnitine supplementation"],"prefix":"10.1017","volume":"61","author":[{"given":"Deborah A.","family":"Ahern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine E.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114589000292_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)42343-1"},{"key":"S0007114589000292_ref007","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19670016"},{"key":"S0007114589000292_ref003","first-page":"181","article-title":"Carnitine biosynthesis","volume":"4","author":"Broquist","year":"1981","journal-title":"Nutritional implications. Nutrition Research"},{"key":"S0007114589000292_ref011","first-page":"23","volume-title":"Biochemical Procedures,","volume":"Vol. 1","author":"Harding","year":"1967"},{"key":"S0007114589000292_ref008","first-page":"39","article-title":"The synthesis of hippurate from benzoate and glycine by rat liver mitochondria","volume":"166","author":"Gatley","year":"1977","journal-title":"Submitochondrial localization and kinetics. Biochemical Journal"},{"key":"S0007114589000292_ref024","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193305000-00004"},{"key":"S0007114589000292_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(77)90513-7"},{"key":"S0007114589000292_ref005","doi-asserted-by":"publisher","DOI":"10.1038\/220917a0"},{"key":"S0007114589000292_ref038","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(08)60309-5"},{"key":"S0007114589000292_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(69)90289-7"},{"key":"S0007114589000292_ref031","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.4.876"},{"key":"S0007114589000292_ref010","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/35.5.1159"},{"key":"S0007114589000292_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.1.36"},{"key":"S0007114589000292_ref012","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19820050"},{"key":"S0007114589000292_ref034","doi-asserted-by":"publisher","DOI":"10.3109\/00365528009181512"},{"key":"S0007114589000292_ref026","first-page":"199","article-title":"Galactose and hepatic metabolism in malnutrition and sepsis in man","volume":"55","author":"Royle","year":"1978","journal-title":"Clinical Science and Molecular Medicine"},{"key":"S0007114589000292_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/105.6.631"},{"key":"S0007114589000292_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(69)90230-7"},{"key":"S0007114589000292_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(78)90021-7"},{"key":"S0007114589000292_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.1.24"},{"key":"S0007114589000292_ref029","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1964.02080060258006"},{"key":"S0007114589000292_ref016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198012113032410"},{"key":"S0007114589000292_ref017","first-page":"271","article-title":"The liver during recovery from protein-calorie malnutrition","volume":"71","author":"McLaren","year":"1968","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"S0007114589000292_ref019","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.2.293"},{"key":"S0007114589000292_ref004","first-page":"665","article-title":"Studies on amino acid metabolism","volume":"27","author":"DeVries","year":"1948","journal-title":"III. Plasma glycine following the ingestion of benzoate. Journal of Clinical Investigation"},{"key":"S0007114589000292_ref020","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/clinchem\/24.1.32","article-title":"Improved radiochemical assay for carnitine and its derivatives in plasma and tissue extracts","volume":"24","author":"Pace","year":"1978","journal-title":"Clinical Chemistry"},{"key":"S0007114589000292_ref022","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/116.5.742"},{"key":"S0007114589000292_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/111.4.733"},{"key":"S0007114589000292_ref025","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.10.1906"},{"key":"S0007114589000292_ref027","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0021-9258(18)65643-1","article-title":"Glycine N-acylase: purification and properties","volume":"208","author":"Schnacter","year":"1954","journal-title":"Journal of Biological Chemistry"},{"key":"S0007114589000292_ref028","first-page":"205","article-title":"Successful carnitine treatment of non-carnitine-deficient lipid storage myopathy","volume":"135","author":"Sengers","year":"1980","journal-title":"Pediatrics"},{"key":"S0007114589000292_ref030","unstructured":"Steel R. G. D. & Torrie J. H. (1975). Principles and Procedures of Statistics. New York: McGraw-Hill."},{"key":"S0007114589000292_ref033","doi-asserted-by":"crossref","unstructured":"Teuchy H. & Van Sumere C. F. (1971). The metabolism of (1-14C)-phenylalanine, (3-14C)-cinnamic acid and (2-14C)-ferrulic acid in the rat. Archives Internationales de Physiologie et de Biochimie 71, 589\u2013595.","DOI":"10.3109\/13813457109085341"},{"key":"S0007114589000292_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-526150-0.50020-5"},{"key":"S0007114589000292_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/28.11.1330"},{"key":"S0007114589000292_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)94666-X"},{"key":"S0007114589000292_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90171-6"},{"key":"S0007114589000292_ref041","first-page":"677","volume-title":"Todd-Sanford Clinical Diagnosis by Laboratory Methods,","author":"Zimmerman","year":"1974"},{"key":"S0007114589000292_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90847-4"},{"key":"S0007114589000292_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90269-1"},{"key":"S0007114589000292_ref015","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0022-2275(20)36985-6","article-title":"An improved and simplified radioisotopic assay for the determination of free and esterified carnitine","volume":"17","author":"McGarry","year":"1976","journal-title":"Journal of Lipid Research"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114589000292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T19:07:57Z","timestamp":1626548877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114589000292\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["S0007114589000292"],"URL":"https:\/\/doi.org\/10.1079\/bjn19890110","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]}}}