{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:51:32Z","timestamp":1766047892174},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6521,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>1. The effects of riboflavin deficiency on growth, whole-body oxygen consumption, cytochrome<jats:italic>c<\/jats:italic>oxidase (<jats:italic>EC<\/jats:italic>1.9.3.1) activity and GDP-binding capacity of brown adipose tissue were measured in three groups of rats: sucking pups, weanling rats, and dams. Control groups were weight-matched, pair-fed or fed<jats:italic>ad lib.<\/jats:italic><\/jats:p><jats:p>2. Riboflavin deficiency reduced growth rate and increased the activation coefficient of erythrocyte glutathione reductase (NAD(P)H) (<jats:italic>EC<\/jats:italic>1.6.4.2), as predicted. In sucking pups it also reduced whole-body O<jats:sub>2<\/jats:sub>consumption per unit body-weight, especially after noradrenaline stimulation. In weanling rats, however, it increased O<jats:sub>2<\/jats:sub>consumption both before and after noradrenaline stimulation.<\/jats:p><jats:p>3. Cytochrome<jats:italic>c<\/jats:italic>oxidase (<jats:italic>EC<\/jats:italic>1.9.9.1) activity of brown adipose tissue was not consistently affected by riboflavin deficiency. Binding of [<jats:sup>3<\/jats:sup>H]GDP to the mitochondria was increased in the deficient weanling rats.<\/jats:p><jats:p>4. Weanling rats therefore, seemed better able to withstand the effects of severe depletion. Their reduced growth and increased non-shivering thermogenesis helped to counteract the unfavourable ratio of riboflavin: other tissuebuilding materials. The relevance for thermoregulation in riboflavin-deficient children is discussed.<\/jats:p>","DOI":"10.1079\/bjn19890137","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"475-483","source":"Crossref","is-referenced-by-count":11,"title":["Riboflavin deficiency, metabolic rate and brown adipose tissue function in sucking and weanling rats"],"prefix":"10.1017","volume":"61","author":[{"given":"B. E.","family":"Patterson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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