{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:27:23Z","timestamp":1774686443018,"version":"3.50.1"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":5972,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:p>A preventive effect of dietary marine<jats:italic>n<\/jats:italic>\u22123 fatty acids on early delivery and toxaemia has recently been hypothesized. In only one published controlled trial fish oil has been given to pregnant women, namely in that conducted during 1938\u20139 in London by the People's League of Health with a dietary supplement containing vitamins, minerals, and halibut liver oil. Although it was of high quality and its findings are hitherto unexplained, neglect and misinterpretation of the trial seem to occur commonly in reviews. Of the 5644 women who were enrolled the 622 withdrawals were independent of treatment. Alternate allocation to treatment was used, producing two groups that were well balanced as to age and parity. The supplement was given from about week 20. The control group did not receive any supplement. Reductions of 20.4% (95% confidence interval 9\u201330%,<jats:italic>P<\/jats:italic>= 0.00083) and 31.5% (95% confidence interval 11\u201347%,<jats:italic>P<\/jats:italic>= 0.0047) were seen in odds of delivering before 40 weeks of gestation and pre-eclampsia respectively. No significant effects were seen on perinatal mortality, average birth weight, deliveries after 40 weeks, hypertension in the absence of oedema and proteinuria, duration of labour, sepsis or breast-feeding occurrence. Later controlled trials with vitamins or minerals given in the same amounts as in this trial have largely failed to show convincing effects as seen here. A controlled trial assessing the isolated effects of fish oil in pregnancy is warranted.<\/jats:p>","DOI":"10.1079\/bjn19900063","type":"journal-article","created":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T23:49:52Z","timestamp":1116546592000},"page":"599-609","source":"Crossref","is-referenced-by-count":147,"title":["A possible preventive effect of low-dose fish oil on early delivery and pre-eclampsia: Indications from a 50-year-old controlled trial"],"prefix":"10.1017","volume":"64","author":[{"given":"Sj\u00far\u00f0ur F.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels J.","family":"Secher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114590001386_ref016","first-page":"663","volume-title":"World Health Organization Bulletin","author":"Kramer","year":"1988"},{"key":"S0007114590001386_ref020","first-page":"110","article-title":"Raised blood pressure in pregnancy: aetiology of pre-eclampsia","author":"MacGillivray","year":"1981","journal-title":"British Journal of Hospital Medicine"},{"key":"S0007114590001386_ref029","volume-title":"A Safe Milk Supply Memorandum: the Compulsory Pasteurisation of Milk","year":"1943"},{"key":"S0007114590001386_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1988.tb00160.x"},{"key":"S0007114590001386_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(86)90052-4"},{"key":"S0007114590001386_ref005","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3233\/CH-1988-8514","article-title":"Effect of eicosapentaenoic acid on RBC filterability and fatty acid composition","volume":"8","author":"Driss","year":"1988","journal-title":"Clinical Hemorheology"},{"key":"S0007114590001386_ref034","first-page":"302","article-title":"Toxemia: new concepts in an old disease","volume":"12","author":"Romero","year":"1988","journal-title":"Seminars in Perinatology"},{"key":"S0007114590001386_ref033","first-page":"990","volume":"53","year":"1983","journal-title":"Nutrition Abstracts and Reviews in Clinical Nutrition"},{"key":"S0007114590001386_ref038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1990.tb02493.x"},{"key":"S0007114590001386_ref030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1946.tb05778.x"},{"key":"S0007114590001386_ref028","first-page":"10","article-title":"Nutrition of expectant and nursing mothers","volume":"ii","year":"1942","journal-title":"Lancet"},{"key":"S0007114590001386_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90112-I"},{"key":"S0007114590001386_ref031","volume-title":"Clinical Trials: a Practical Approach","author":"Pocock","year":"1983"},{"key":"S0007114590001386_ref024","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.08.070188.002505"},{"key":"S0007114590001386_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90055-3"},{"key":"S0007114590001386_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90090-7"},{"key":"S0007114590001386_ref012","first-page":"163","article-title":"Total lipids and fatty acids composition of polar and neutral lipids in different tissues of Atlantic halibut, Hippoglossus hippoglossus (L)","volume":"73","author":"Haug","year":"1988","journal-title":"Sarcia"},{"key":"S0007114590001386_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92330-X"},{"key":"S0007114590001386_ref011","first-page":"305","volume-title":"Biological Membranes: Aberrations in Membrane Structure and Function","author":"Hansen","year":"1988"},{"key":"S0007114590001386_ref039","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.4.784"},{"key":"S0007114590001386_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(84)90295-0"},{"key":"S0007114590001386_ref008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4282.144"},{"key":"S0007114590001386_ref013","first-page":"114","volume-title":"Effectiveness and Satisfaction in Antenatal Care","author":"Hemminki","year":"1982"},{"key":"S0007114590001386_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03278.x"},{"key":"S0007114590001386_ref002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210604"},{"key":"S0007114590001386_ref023","volume-title":"The People's League of Health: the Inception of the League","author":"Nethersole","year":"1922"},{"key":"S0007114590001386_ref010","first-page":"290","volume-title":"Effective Care in Pregnancy and Childbirth","author":"Green","year":"1989"},{"key":"S0007114590001386_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb00042.x"},{"key":"S0007114590001386_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90482-X"},{"key":"S0007114590001386_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1978.tb14905.x"},{"key":"S0007114590001386_ref041","first-page":"1","article-title":"The role of nutrition in pregnancy course and outcome","volume":"5","author":"Worthington-Roberts","year":"1985","journal-title":"Journal of Environmental Pathology, Toxicology, and Oncology"},{"key":"S0007114590001386_ref027","first-page":"77","article-title":"Nutrition of expectant and nursing mothers","volume":"ii","year":"1942","journal-title":"British Medical Journal"},{"key":"S0007114590001386_ref040","volume-title":"Nutrition in Pregnancy","author":"Campbell","year":"1983"},{"key":"S0007114590001386_ref032","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0065-3101(22)00709-5","article-title":"Prevention of prematurity","volume":"15","author":"R\u00e4ih\u00e4","year":"1968","journal-title":"Advances in Pediatrics"},{"key":"S0007114590001386_ref036","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/003591574203600210","volume":"36","year":"1942","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"S0007114590001386_ref035","volume-title":"Family Diet and Health in Pre-war Britain: a Dietary and Clinical Survey","year":"1955"},{"key":"S0007114590001386_ref025","first-page":"12","article-title":"Nutrition in pregnancy","volume":"2","year":"1944","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114590001386_ref017","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198409000-00005"},{"key":"S0007114590001386_ref037","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198908103210603"},{"key":"S0007114590001386_ref022","doi-asserted-by":"publisher","DOI":"10.1159\/000298772"},{"key":"S0007114590001386_ref021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1947.tb10764.x"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114590001386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T01:32:07Z","timestamp":1706232727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114590001386\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["S0007114590001386"],"URL":"https:\/\/doi.org\/10.1079\/bjn19900063","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}