{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:14:17Z","timestamp":1764688457885},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6217,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>The influence of dietary lipids on the liver microsomal mixed function oxidase system and on pentobarbital-induced sleeping time was studied in rats. Giving diets containing (g\/kg) 150 olive oil, 150 lard or 150 soya-bean oil for 21 d (Expt 1) increased the cytochrome P-450 content in the order: olive oil &lt; lard &lt; soya-bean oil. When diets containing (g\/kg) 150 lard, 150 soya-bean oil, 150 sardine oil or an equal mixture of 50 of each oil were given for 15 d (Expt 2), the cytochrome P-450 content and aminopyrine<jats:italic>N<\/jats:italic>-demethylase activity were significantly higher in the sardine-oil and mixed-oil groups than in the lard group, and the activity of aminopyrine N-demethylase was also significantly higher in the soya-bean oil group compared with the lard group. A significantly higher activity of NADPH-cytochrome c reductase (<jats:italic>EC<\/jats:italic>1.6.2.5) was observed in the sardine-oil group than in the other three groups. Aniline hydroxylase activity and cytochrome b<jats:sup>5<\/jats:sup>content remained unchanged in all the groups. Pentobarbital-induced sleeping time measured on day 15 (Expt 2) varied inversely with the changes in cytochrome P-450 content and aminopyrine<jats:italic>N<\/jats:italic>-demethylase activity in the three single-fat groups, but not in the mixed-oil group, reflecting liver microsomal metabolic activity for pentobarbital in vivo. From these results, it appears that high intakes of polyunsaturated fatty acids (18:2n-6, 18:3n-3, 20:5n-3 and 22:6n-3) stimulate the liver microsomal mixed function oxidase system.<\/jats:p>","DOI":"10.1079\/bjn19900112","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T07:49:51Z","timestamp":1118303391000},"page":"249-257","source":"Crossref","is-referenced-by-count":28,"title":["Mixed function oxidases in response to different types of dietary lipids in rats"],"prefix":"10.1017","volume":"63","author":[{"given":"Morio","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Oh-Hashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Nishide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114590000319_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(77)90367-7"},{"key":"S0007114590000319_ref006","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19790061"},{"key":"S0007114590000319_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF02533047"},{"key":"S0007114590000319_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF02532429"},{"key":"S0007114590000319_ref002","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/107.7.1340","article-title":"Report of the American Institute of Nutrition Ad Hoc Committee on standards for nutritional studies","volume":"107","author":"Bieri","year":"1977","journal-title":"Journal of Nutrition"},{"key":"S0007114590000319_ref003","first-page":"185","article-title":"A role of the dietary lipid in the ability of phenobarbital to stimulate drug detoxification","volume":"185","author":"Century","year":"1973","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"S0007114590000319_ref019","doi-asserted-by":"publisher","DOI":"10.1042\/bj0550416"},{"key":"S0007114590000319_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(76)90287-2"},{"key":"S0007114590000319_ref024","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.4.123"},{"key":"S0007114590000319_ref022","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a129248"},{"key":"S0007114590000319_ref021","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide-binding pigment of liver microsomes. 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