{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:04:17Z","timestamp":1760645057037},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6217,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:p>The present study was designed to examine the effects of various levels of fructose in a copper-deficient diet on some of the signs of Cu deficiency in the rat. Weanling male rats were randomly assigned to one of five diets which contained 0.6 \u03bcg Cu\/g diet and 627 g carbohydrate\/kg which was (g\/kg): 627 fructose (diet 100); 470 fructose, 157 starch (diet 75); 313.5 fructose, 313.5 starch (diet 50); 157 fructose, 470 starch (diet 25); or 627 starch (diet 0). Rats ate their respective diets for either 2 or 5 weeks. There was a significant linear inverse response of body-weight (<jats:italic>P<\/jats:italic>&lt; 0.0001), packed cell volume (<jats:italic>p<\/jats:italic>&lt; 0.0001) and erythrocyte superoxide dismutase (<jats:italic>EC<\/jats:italic>1.15.1.1) activity (<jats:italic>P<\/jats:italic>&lt; 0.008) to increasing levels of dietary fructose and a direct linear response of plasma cholesterol (<jats:italic>P<\/jats:italic>&lt; 0.05) and blood urea nitrogen concentrations (<jats:italic>P<\/jats:italic>&lt; 0.001) to increasing levels of dietary fructose. Liver, kidney and pancreatic Cu concentrations decreased in a dose-response manner as the level of dietary fructose increased. In general, if fructose was included in the diet the signs of Cu deficiency were exacerbated in a dose-response manner.<\/jats:p>","DOI":"10.1079\/bjn19900124","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T07:49:51Z","timestamp":1118303391000},"page":"387-395","source":"Crossref","is-referenced-by-count":17,"title":["The effect of various levels of fructose in a copper-deficient diet on Cu deficiency in male rats"],"prefix":"10.1017","volume":"63","author":[{"given":"Charles 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