{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T16:32:18Z","timestamp":1713976338375},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":6156,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p>The purpose of the present study was to test the hypothesis that the already well-established mitochondria1 lesion in fatty acid oxidation in riboflavin-deficient experimental animals, might be accompanied by an alteration in vivo in the kinetics of oxidation of labelled adipic acid. This dicarboxylic acid was chosen for testing as a metabolic probe because a block in its oxidation was already apparent from urine analysis of riboflavin-deficient animals, whereas the oxidation of medium- or long-chain monocarboxylic acids seemed to be little affected by deficiency in vivo. Female adult Norwegian hooded rats fed on purified diets containing either 15 mg riboflavin\/kg diet (controls) or about 0.4 mg\/kg (riboflavin-deficient) received an intragastric dose of either [l,6-I4C] adipic acid or [l-'4C] octanoic acid. Expired carbon dioxide was then collected in an alkaline trap over 3 h, for determination of radioactivity.This test was repeated at intervals for up to 2 weeks following riboflavin repletion of the deficient animals, and in riboflavin-dosed controls. Whereas the rate and extent of ['4C]octanoic acid oxidation was not significantly affected by the deficiency or repletion, the extent of [I4C]adipic acid oxidation was markedly and significantly increased during repletion of the deficient animals. The time-course indicated a temporary overshoot, followed by a slow return to the control values over 1\u20132 weeks. Adipate oxidation was also much less affected by a preceding period of overnight starvation, than was octanoate oxidation. Thus, adipic acid (or a related metabolic probe) may have appropriate properties for the design of a functional test of fatty acid oxidation efficiency, during riboflavin deficiency or allied metabolic conditions in human subjects.<\/jats:p>","DOI":"10.1079\/bjn19900142","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"553-562","source":"Crossref","is-referenced-by-count":9,"title":["Liberation of<sup>I4<\/sup>CO<sub>2<\/sub>from [<sup>14<\/sup>C]adipic acid and [<sup>14<\/sup>C]octanoic acid by adult rats during riboflavin deficiency and its reversal"],"prefix":"10.1017","volume":"63","author":[{"given":"C. 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