{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:33:24Z","timestamp":1768012404482,"version":"3.49.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":5302,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p>The influence of dietary copper on lipid composition, phospholipid-fatty acid and protein profiles and fluidity of the erythrocyte membranes of rats is reported. In general Cu deficiency in rats induced some changes in the phospholipid-fatty acid profile of erythrocyte membranes when compared with Cu-adequate animals. Stearic (18:0) and docosadienoic (22:2<jats:italic>n<\/jats:italic>-3) acids contents, for example, were significantly increased (<jats:italic>P<\/jats:italic>&lt; 0.001) while oleic (18:1<jats:italic>n<\/jats:italic>-9) and linolenic (18:3<jats:italic>n<\/jats:italic>-3) acid contents were significantly depressed (<jats:italic>P<\/jats:italic>&lt; 0.001) as a result of Cu deficiency. Moreover the cholesterol:phospholipids molar ratio and the cholesterol (mol):membrane proteins (mg) ratio in Cu-deficient rats were, to different degrees, significantly lower than in animals fed on Cu-adequate diets. In addition, diets deficient in Cu led to a reduction in erythrocyte membrane fluidity (<jats:italic>P<\/jats:italic>&lt; 0.001) as assessed by the intramolecular excimer fluorescence of 1,3-di(1-pyrenyI) propane. However, no significant alteration in the phospholipid:protein ratio was observed as a result of differences in dietary treatment. The pattern of erythrocyte membrane proteins obtained with sodium dodecyl sulphate-polyacrylamide gel electro-phoresis did not seem to be influenced by Cu-deficient diets.<\/jats:p>","DOI":"10.1079\/bjn19920101","type":"journal-article","created":{"date-parts":[[2005,9,15]],"date-time":"2005-09-15T01:16:17Z","timestamp":1126746977000},"page":"435-443","source":"Crossref","is-referenced-by-count":12,"title":["Lipid composition and fluidity of the erythrocyte membrane in copper-deficient rats"],"prefix":"10.1017","volume":"68","author":[{"given":"K. M.","family":"Abu-Salah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Alothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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