{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:27:05Z","timestamp":1767652025865},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":5180,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>Naked mole rats (<jats:italic>Heterocephalus glaber<\/jats:italic>) lead a strictly subterranean existence and appear to be naturally deficient in cholecalciferol (D<jats:sub>3<\/jats:sub>). Oral supplementation with D<jats:sub>3<\/jats:sub>(D<jats:sub>s<\/jats:sub>) led to a 1.8-fold increase in food intake and the associated enlargement (1.4-fold) of the caecum. The effect of D<jats:sub>s<\/jats:sub>, and the concomitant increase in food intake, on caecal fermentation efficiency when animals were fed on a carrotbased diet was determined by measuring the rate of both gas production and short-chain fatty acid (SCFA) production. Microbial-controlled fermentation processes in the caecum were enhanced with D<jats:sub>s<\/jats:sub>when compared with animals not receiving a D<jats:sub>3<\/jats:sub>supplement (D<jats:sub>n<\/jats:sub>). Both the rates of gas production (D<jats:sub>n<\/jats:sub>10.76 (SE 0.77), D<jats:sub>s<\/jats:sub>15.20 (SE 1.77) ml\/g dry matter (DM) per h) and SCFA production (D<jats:sub>n<\/jats:sub>463.0 (SE 33.7), D<jats:sub>s<\/jats:sub>684.3 (SE 74.8)<jats:italic>\u03bc<\/jats:italic>mol\/g DM per h) increased more than 1.4-fold per g DM caecal substrate. These factors contributed to the higher digestibility of the food in D<jats:sub>s<\/jats:sub>animals. The larger quantity of energy available to D<jats:sub>3<\/jats:sub>-replete naked mole rats was not used in anabolic processes, for these animals maintained mass. These findings suggest that metabolic rate in D<jats:sub>3<\/jats:sub>-replete animals was elevated. Thus, despite improved gut function, D<jats:sub>3<\/jats:sub>-replete animals may be disadvantaged by their higher energy and food requirements in their natural milieu.<\/jats:p>","DOI":"10.1079\/bjn19930025","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T07:49:51Z","timestamp":1118303391000},"page":"233-241","source":"Crossref","is-referenced-by-count":4,"title":["Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (<i>Heterocephulus gluber<\/i>), when fed on a carrot diet"],"prefix":"10.1017","volume":"69","author":[{"given":"Shlomo","family":"Yahav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Buffenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114593000273_ref005","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1290021"},{"key":"S0007114593000273_ref002","first-page":"S119","article-title":"Vitamin D metabolism and expression in chthonic naked mole rats","volume":"3","author":"Buffenstein","year":"1988","journal-title":"Journal of Bone and Mineral Research"},{"key":"S0007114593000273_ref014","first-page":"467483","volume-title":"Biology of the Naked Mole Rat","author":"Jarvis","year":"1991"},{"key":"S0007114593000273_ref023","first-page":"88","article-title":"Evidence for in-vitro production of vitamin D2 and vitamin D3 metabolites by rumen microbes","volume":"63","author":"Sommerfeldt","year":"1980","journal-title":"Journal of Dairy Science"},{"key":"S0007114593000273_ref019","doi-asserted-by":"publisher","DOI":"10.1210\/endo-115-1-191"},{"key":"S0007114593000273_ref028","unstructured":"Zar J. H. (1974). Biostatistiral Analysis. Englewood Cliffs, New Jersey: Prentice Hall."},{"key":"S0007114593000273_ref026","doi-asserted-by":"publisher","DOI":"10.1007\/BF00347605"},{"key":"S0007114593000273_ref008","doi-asserted-by":"publisher","DOI":"10.1210\/endo-113-4-1511"},{"key":"S0007114593000273_ref003","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1310197"},{"key":"S0007114593000273_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4565(91)90030-6"},{"key":"S0007114593000273_ref011","unstructured":"Davies J. (1988). Laboratory Methods. 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