{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:53:48Z","timestamp":1762520028192},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":5121,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:p>The effect of riboflavin deficiency on gastrointestinal Fe distribution and loss was studied in weanling rats. Riboflavin deficiency was associated with a significant increase in crypt depth in the upper and mid small intestine and a twofold increase in the rate of crypt cell production compared with weight-matched and<jats:italic>ad lih<\/jats:italic>.-fed control rats. The rate of loss of endogenous Fe, measured as faecal<jats:sup>59<\/jats:sup>Fe after intraperitoneally administered<jats:sup>59<\/jats:sup>Fe, was twice that from riboflavin-deficient rats compared with weightmatched controls. We suggest that while there may be a contribution from turnover of enterocytes with an enhanced Fe content, enhanced Fe loss associated with riboflavin deficiency is due predominantly to an accelerated rate of small-intestinal epithelial turnover.<\/jats:p>","DOI":"10.1079\/bjn19930055","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T07:49:51Z","timestamp":1118303391000},"page":"553-561","source":"Crossref","is-referenced-by-count":39,"title":["A proposed intestinal mechanism for the effect of riboflavin deficiency on iron loss in the rat"],"prefix":"10.1017","volume":"69","author":[{"given":"Hilary J.","family":"Powers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence T.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Austin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K.","family":"Beresford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S000711459300056X_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.5.852"},{"key":"S000711459300056X_ref011","volume-title":"Laboratory Tests fhr the Assessment of Nutritional Status","author":"Sauberlich","year":"1974"},{"key":"S000711459300056X_ref008","first-page":"371","article-title":"Effects of riboflavin deficiency in rats on some aspects of iron metabolism","volume":"43","author":"Powers","year":"1983","journal-title":"International Journul of Vitamin and Nutrition Re.search"},{"key":"S000711459300056X_ref003","first-page":"136","article-title":"The effects of riboflavin administration on iron metabolism parameters in a school-going population","volume":"49","author":"Buzina","year":"1979","journal-title":"International Journal of Vitamin and Nutrition Research"},{"key":"S000711459300056X_ref009","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910107"},{"key":"S000711459300056X_ref004","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19850014"},{"key":"S000711459300056X_ref001","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19860097"},{"key":"S000711459300056X_ref013","first-page":"595","article-title":"The kinetics of villus cell populations in the mouse small intestine","volume":"15","author":"Wright","year":"1982","journal-title":"Cell and Tissue Kinetics"},{"key":"S000711459300056X_ref005","doi-asserted-by":"publisher","DOI":"10.1042\/cs0740301"},{"key":"S000711459300056X_ref006","doi-asserted-by":"publisher","DOI":"10.1159\/000177208"},{"key":"S000711459300056X_ref002","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0021-9258(18)56696-5","article-title":"The fluorimetric measurement of the nucleotides of riboflavin and their concentration in tissues","volume":"180","author":"Bessey","year":"1949","journal-title":"Journal of Biological Chemistry"},{"key":"S000711459300056X_ref010","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19880047"},{"key":"S000711459300056X_ref012","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198907000-00010"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S000711459300056X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T14:06:02Z","timestamp":1626012362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S000711459300056X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["S000711459300056X"],"URL":"https:\/\/doi.org\/10.1079\/bjn19930055","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]}}}