{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:15:19Z","timestamp":1759331719422},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":4725,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:p><jats:italic>Cryptomys hottentotus<\/jats:italic> has no access to dietary or endogenous sources of cholecalciferol (D<jats:sub>3<\/jats:sub>). Serum concentrations of calcifediol (25(OH)D<jats:sub>3<\/jats:sub>) were undetectable (&lt; 5 ng\/ml) and calcitriol (1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>), although detectable in plasma, was at a low concentration (31.40) (SEM 3.06 pg\/ml). Despite their naturally impoverished vitamin D status, these animals exhibited highly efficient mineral absorption processes (Ca apparent fractional absorption efficiency, AFA (%) 95.33 (SEM 1.36); inorganic P (P<jats:sub>i<\/jats:sub>) AFA (%) 93.49 (SEM 0.81)). Furthermore, plasma mineral content was tightly regulated (Ca 2.57 (SEM 0.08) mmol\/l; Mg 1.23 (SEM 0.05) mmol\/l; P<jats:sub>i<\/jats:sub> 2.12 (SEM 0.15) mmol\/1). Mode of uptake in <jats:italic>C. hottentotus<\/jats:italic> was unlike that in other D<jats:sub>3<\/jats:sub>-replete mammals. First, passive (rather than active) uptake occurred in the traditional site of active Ca absorption (with serosal: mucosal (S:M) ratios in the duodenum of 1.32 (SEM 0.13)), and the only site of active Ca uptake was the hindgut (caecum S:M 3.35 (SEM 0.46); proximal colon S:M 2.13 (SEM 0.30)). Despite the presence of active uptake in these hindgut regions, their overall contribution to the daily rate of mineral absorption was small (9.53 (SEM 1.27)%). These underground inhabitants rely upon highly efficient, passive mineral uptake. This is adequate to meet their mineral requirements and maintain mineral homeostasis in the absence of vitamin D.<\/jats:p>","DOI":"10.1079\/bjn19940164","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:09:04Z","timestamp":1118498944000},"page":"573-582","source":"Crossref","is-referenced-by-count":8,"title":["Passive uptake in the small intestine and active uptake in the hindgut contribute to the highly efficient mineral metabolism of the common mole-rat, <i>Cryptomys hottentotus<\/i>"],"prefix":"10.1017","volume":"71","author":[{"given":"Tammy","family":"Pitcher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Buffenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114594000632_ref013","doi-asserted-by":"publisher","DOI":"10.1139\/o67-235"},{"key":"S0007114594000632_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(91)90178-9"},{"key":"S0007114594000632_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(85)90048-1"},{"key":"S0007114594000632_ref015","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/ajcn\/51.2.290","article-title":"Intestinal calcium absorption: a vitamin D hormone mediated adaptive response","volume":"51","author":"Norman","year":"1990","journal-title":"American Journal of Clinical Nutrition"},{"key":"S0007114594000632_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)64791-0"},{"key":"S0007114594000632_ref022","first-page":"30","volume-title":"Primer on the Metabolic Bone Diseuses and Disorders of 'Minerul Metaholism","author":"Silverberg","year":"1990"},{"key":"S0007114594000632_ref018","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-58-1-91"},{"key":"S0007114594000632_ref009","first-page":"G528","article-title":"Effect of vitamin D3 on duodenal calcium absorption in vivo during early development","volume":"246","author":"Dostal","year":"1984","journal-title":"American Journal of Physiology"},{"key":"S0007114594000632_ref017","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/jn\/122.1.108","article-title":"Dietary calcium content, calcium balance and mode of uptake in a subterranean mammal, the Damara mole-rat","volume":"122","author":"Pitcher","year":"1992","journal-title":"Journal of Nutrition"},{"key":"S0007114594000632_ref008","volume-title":"The Rodents of Southern Africa: Notes on their Identification, Distribution, Ecology and Taxonomy","author":"De Graaff","year":"1981"},{"key":"S0007114594000632_ref026","first-page":"73","article-title":"The effect of low dietary calcium and calcium supplementation on calcium metabolism and bone in the immature, growing rat","volume":"4","author":"Walling","year":"1974","journal-title":"Bone and Mineral"},{"key":"S0007114594000632_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114575000359"},{"key":"S0007114594000632_ref004","first-page":"S156","article-title":"Vitamin D-independent stimulation of intestinal calcium and phosphorus absorption during reproduction","volume":"3","author":"Brommage","year":"1988","journal-title":"Journal of Bone and Mineral Research"},{"key":"S0007114594000632_ref021","first-page":"633","volume-title":"Vitamin D. 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