{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:08:37Z","timestamp":1790748517370,"version":"4.1.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":4177,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>To examine the hormonal effects of isoflavones, of which soyabean is a rich source, fifteen healthy non-vegetarian premenopausal women were studied over 9 months. They lived in a metabolic suite for between 4 and 6 months where their diet and activity levels were kept constant and their hormonal status was measured over two or three menstrual cycles. During one (control) menstrual cycle a normal but constant diet containing no soyabean products was fed. Then, over a second complete cycle six subjects consumed a similar diet into which 60 g textured vegetable protein (TVP)\/d, containing 45 mg conjugated isoflavones, had been incorporated. Three participants had 50 g miso (a fermented soyabean paste), containing 25 mg unconjugated isoflavones, added daily to their diet over a menstrual cycle, and six others consumed 28 g TVP\/d, containing 23 mg conjugated isoflavones. Five participants completed a third diet period where they were randomly assigned to consume either the control diet over a cycle, or a similar diet incorporating 60 g of a soyabean product which had had the isoflavones chemically extracted (Arcon F). Follicular phase length was significantly (<jats:italic>P<\/jats:italic>&lt; 0\u00b701) increased and peak progesterone concentrations were delayed with 60 g TVP but no effects were observed with Arcon F. The increase in menstrual cycle length did not reach statistical significance in the three subjects who ate 50 g miso\/d, but peak progesterone levels were significantly (<jats:italic>P<\/jats:italic>&lt; 0\u00b705) delayed. Mid-cycle peaks of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were suppressed with 45 mg conjugated isoflavones as 60 g TVP (<jats:italic>P<\/jats:italic>&lt; 0\u00b705 and<jats:italic>P<\/jats:italic>&lt; 0\u00b701 respectively). No other changes in sex-steroid hormone levels were observed on any of the other diets. A significant reduction in total cholesterol was found with 45 mg conjugated isoflavones (<jats:italic>P<\/jats:italic>&lt; 0\u00b705), but not with 23 mg conjugated isoflavone-free Arcon F. There was no effect of menstrual cycle phase on transit time.<\/jats:p>","DOI":"10.1079\/bjn19950160","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:09:04Z","timestamp":1118513344000},"page":"587-601","source":"Crossref","is-referenced-by-count":206,"title":["Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products"],"prefix":"10.1017","volume":"74","author":[{"given":"Aedin","family":"Cassidy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Bingham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Setchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114595001619_ref013","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0340215"},{"key":"S0007114595001619_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)47478-9"},{"key":"S0007114595001619_ref028","first-page":"413","article-title":"Diet and coronary heart disease","volume":"36C","author":"Oliver","year":"1982","journal-title":"Human Nutrition: Clinical Nutrition"},{"key":"S0007114595001619_ref034","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0290001"},{"key":"S0007114595001619_ref024","doi-asserted-by":"publisher","DOI":"10.1210\/endo-103-5-1860"},{"key":"S0007114595001619_ref026","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13762.x"},{"key":"S0007114595001619_ref006","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0002-8223(21)01236-0","article-title":"Review of clinical studies on cholesterol lowering response to soy protein","volume":"91","author":"Carroll","year":"1991","journal-title":"Journal of the American Dietetic Association"},{"key":"S0007114595001619_ref005","doi-asserted-by":"publisher","DOI":"10.1042\/cs0640629"},{"key":"S0007114595001619_ref004","first-page":"239","volume-title":"Mutagens and Carcinogens in the Diet","author":"Barnes","year":"1990"},{"key":"S0007114595001619_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90350-P"},{"key":"S0007114595001619_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/gut.17.3.210"},{"key":"S0007114595001619_ref029","volume-title":"McCance and Widdowson's The Composition of Foods","author":"Paul","year":"1978"},{"key":"S0007114595001619_ref025","volume-title":"International Agency for Research on Cancer Scientific Publication","volume":"5","author":"Muir","year":"1987"},{"key":"S0007114595001619_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90343-3"},{"key":"S0007114595001619_ref016","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850901)56:5<1206::AID-CNCR2820560541>3.0.CO;2-9"},{"key":"S0007114595001619_ref031","first-page":"1","article-title":"Basal metabolic rate","volume":"39C","author":"Schofield","year":"1985","journal-title":"Human Nutrition: Clinical Nutrition"},{"key":"S0007114595001619_ref009","doi-asserted-by":"publisher","DOI":"10.1021\/jf00035a027"},{"key":"S0007114595001619_ref027","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.11.2020"},{"key":"S0007114595001619_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91507-0"},{"key":"S0007114595001619_ref032","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/40.3.569"},{"key":"S0007114595001619_ref003","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0015-0282(16)45805-X","article-title":"Hormonal characteristics of long cycles in fertile women","volume":"36","author":"Arksol","year":"1981","journal-title":"Fertiliry Sterility"},{"key":"S0007114595001619_ref021","doi-asserted-by":"publisher","DOI":"10.1210\/endo-100-5-1252"},{"key":"S0007114595001619_ref007","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/ajcn\/60.3.333","article-title":"Biological effects of isoflavones present in soy in premenopausal women: implications for the prevention of breast cancer","volume":"60","author":"Cassidy","year":"1994","journal-title":"American Journal of Clinical Nutrition"},{"key":"S0007114595001619_ref019","first-page":"624","article-title":"Endocrine effects of adjuvant chemotherapy and long-term Tamoxifen administration on node-positive patients with breast cancer","volume":"47","author":"Jordan","year":"1987","journal-title":"Cancer Research"},{"key":"S0007114595001619_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1981.168"},{"key":"S0007114595001619_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(76)90022-0"},{"key":"S0007114595001619_ref039","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/64.2.285"},{"key":"S0007114595001619_ref036","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0520299"},{"key":"S0007114595001619_ref040","first-page":"56","volume-title":"The menstrual cycle. Major Problems in Obstetrics and Gynaecology","volume":"7","author":"Vollman","year":"1977"},{"key":"S0007114595001619_ref037","first-page":"77","article-title":"Variation of the human menstrual cycle through reproductive life","volume":"12","author":"Treolar","year":"1967","journal-title":"International Journal of Fertility"},{"key":"S0007114595001619_ref011","doi-asserted-by":"publisher","DOI":"10.1210\/endo-28-5-747"},{"key":"S0007114595001619_ref008","doi-asserted-by":"publisher","DOI":"10.1210\/endo-100-1-91"},{"key":"S0007114595001619_ref023","first-page":"143","article-title":"Individual variation in gonadotrophin and steroids and in the lengths of the follicular and luted phases in women with regular menstrual cycles","volume":"2","author":"Lenton","year":"1983","journal-title":"Clinical Reproduction and Fertility"},{"key":"S0007114595001619_ref017","first-page":"41","volume-title":"Diet, Nutrition and Cancer","author":"Hirayama","year":"1986"},{"key":"S0007114595001619_ref030","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/ajcn\/53.4.879","article-title":"Menstrual differences due to vegetarian and nonvegetarian diets","volume":"53","author":"Pedersen","year":"1991","journal-title":"American Journal of Clinical Nutrition"},{"key":"S0007114595001619_ref038","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/1.6.469"},{"key":"S0007114595001619_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(90)90220-3"},{"key":"S0007114595001619_ref035","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0370231"},{"key":"S0007114595001619_ref015","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1093\/jn\/121.10.1693","article-title":"Dietary soya bean isolate and methionine supplementation affect mammary tumour progression in rats","volume":"121","author":"Hawrylewicz","year":"1991","journal-title":"Journal of Nutrition"},{"key":"S0007114595001619_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92867-2"},{"key":"S0007114595001619_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(86)90310-9"},{"key":"S0007114595001619_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)94608-4"},{"key":"S0007114595001619_ref042","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6058.425"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114595001619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T15:44:32Z","timestamp":1706283872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114595001619\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["S0007114595001619"],"URL":"https:\/\/doi.org\/10.1079\/bjn19950160","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}