{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T19:35:05Z","timestamp":1760729705171},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":4146,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:p>In order to induce a range of vitamin A-deficient states in young growing rats and to study the effect of vitamin A deficiency on Fe status, we designed the following two-generation experiment. Dams were fed on diets with one of five vitamin A levels from 2 weeks before and throughout pregnancy and lactation. The pups received the same diets as their mothers both before and after weaning. The five dietary levels of vitamin A were 1200, 450, 150, 75 and 0 retinol equivalents\/kg feed. Vitamin A intake did not affect reproduction outcome, nor were body and liver weights of the pups affected when they were 3\u00b75 weeks old. Male pups with normal vitamin A status had higher plasma retinol levels than female pups. Vitamin A status of the offspring was affected from 3\u00b75 weeks onwards. Body and liver weights were decreased in the male pups given the lowest dietary vitamin A levels from week 6\u00b75 onwards but not in the female pups. Fe status was marginally affected. Haemoglobin levels were increased and total Fe-binding capacity was decreased in the groups given no dietary vitamin A at week 9\u00b75. Splenic Fe was increased only in the male pups given the lowest levels of dietary vitamin A. However, as a whole, Fe status was only mildly affected and subject to considerable variation. We conclude that the two-generation rat model described here is not suitable for studying effects of vitamin A deficiency on Fe metabolism.<\/jats:p>","DOI":"10.1079\/bjn19950172","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T04:07:20Z","timestamp":1126930040000},"page":"689-700","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of a two-generation rat model for vitamin A deficiency and the interrelationship with iron metabolism"],"prefix":"10.1017","volume":"74","author":[{"given":"Annet J. C.","family":"Roodenburg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clive E.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hovenier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton C.","family":"Beynen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114595001735_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.8.1410"},{"key":"S0007114595001735_ref019","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19940176"},{"key":"S0007114595001735_ref018","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19960165"},{"key":"S0007114595001735_ref017","volume-title":"Nutrient Requirements of Laboratory Animals","year":"1978"},{"key":"S0007114595001735_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.3.595"},{"key":"S0007114595001735_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.1.87"},{"key":"S0007114595001735_ref010","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/106.12.1817"},{"key":"S0007114595001735_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/17.3.131"},{"key":"S0007114595001735_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1926.02680070022006"},{"key":"S0007114595001735_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.5.876"},{"key":"S0007114595001735_ref004","doi-asserted-by":"publisher","DOI":"10.1042\/bj2470053"},{"key":"S0007114595001735_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.8.1033"},{"key":"S0007114595001735_ref024","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19920085"},{"key":"S0007114595001735_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.5.1271"},{"key":"S0007114595001735_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.7.1439"},{"key":"S0007114595001735_ref006","first-page":"1435","article-title":"Dietary vitamin A restriction produces marginal vitamin A status in young rats","volume":"123","author":"Gardner","year":"1993","journal-title":"Journal of Nutrition"},{"key":"S0007114595001735_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.2.332"},{"key":"S0007114595001735_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/56.6.988"},{"key":"S0007114595001735_ref020","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19930173"},{"key":"S0007114595001735_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.1.129"},{"key":"S0007114595001735_ref015","first-page":"389","article-title":"Hematological studies in vitamin A deficient children","volume":"47","author":"Mohanram","year":"1977","journal-title":"International Journal of Vitamin and Nutrition Research"},{"key":"S0007114595001735_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92246-P"},{"key":"S0007114595001735_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.1.76"},{"key":"S0007114595001735_ref001","unstructured":"Beaton G. H. , Martorell R. , Aronson K. J. , Edmonston B. , McCabe G. , Ross A. C. & Harvey B. (1993). Effectiveness of Vitamin A Supplementation in the Control of Young Child Morbidity and Mortality in Developing Countries. State-of-the-Art Series, Nutrition Policy Discussion Paper No. 13. Geneva:ACC\/SCN."}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114595001735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T20:28:59Z","timestamp":1557779339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114595001735\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["S0007114595001735"],"URL":"https:\/\/doi.org\/10.1079\/bjn19950172","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]}}}