{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:26:19Z","timestamp":1764001579954},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":3872,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>The present study was designed to test the hypothesis that increasing short-chain fatty acid (SCFA)production in the large bowel increases gut epithelial proliferation rate (EPR). Two experiments were carried out in which rats were fed on bread (wholemeal or white)-based diets containing graded amounts of cooked haricot (<jats:italic>Phaseofus vulgaris<\/jats:italic>) beans; the latter are a rich source of fermentable carbohydrates. Consumption of beans was associated with several-fold increases in SCFA production with the greatest relative increase being for butyrate. Despite the very large increase in SCFA production, there was no evidence that this had any effect on EPR in the duodenum. Where the basal diet contained wholemeal bread (Expt 1) there was no effect of enhanced SCFA supply on EPR in either the caecum or colon, but with the white bread-based diet (Expt 2) adding beans produced increments in both SCFA supply and EPR in the caecum. Evidence that SCFA are responsible for enhanced EPR above normal levels is not convincing. In those instances where enhanced SCFA supply is associated with increased EPR, the increase may be (1) from a hypoproliferative state towards normal, (2) a transient phenomenon accompanying tissue hypertrophy or (3) a homeostatic response to increased cell loss by cell sloughing or apoptosis. It is not likely that there is any direct link with risk of colon cancer<\/jats:p>","DOI":"10.1079\/bjn19960031","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:09:04Z","timestamp":1118513344000},"page":"273-286","source":"Crossref","is-referenced-by-count":14,"title":["Tissue hypertrophy and epithelial proliferation rate in the gut of rats fed on bread and haricot beans (<i>Phaseolus vulgaris<\/i>)"],"prefix":"10.1017","volume":"76","author":[{"given":"Fiona B.","family":"Key","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devina","family":"McClean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Mathers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114596001341_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90263-7"},{"key":"S0007114596001341_ref022","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910034"},{"key":"S0007114596001341_ref006","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19900057"},{"key":"S0007114596001341_ref016","first-page":"47A","article-title":"Effects on volatile fatty acid production and gut epithelial proliferation of adding haricot beans to a wholemeal bread diet","volume":"48","author":"Key","year":"1989","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114596001341_ref039","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(62)89406-5"},{"key":"S0007114596001341_ref018","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19950143"},{"key":"S0007114596001341_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.11.1610"},{"key":"S0007114596001341_ref043","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19880091"},{"key":"S0007114596001341_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91220-3"},{"key":"S0007114596001341_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(88)80019-2"},{"key":"S0007114596001341_ref023","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19900150"},{"key":"S0007114596001341_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.1.37"},{"key":"S0007114596001341_ref017","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19930050"},{"key":"S0007114596001341_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.4.353"},{"key":"S0007114596001341_ref037","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(78)83694-7"},{"key":"S0007114596001341_ref042","volume-title":"The Biology of Epithelial Cell Populations","volume":"2","author":"Wright","year":"1984"},{"key":"S0007114596001341_ref029","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.12.1391"},{"key":"S0007114596001341_ref034","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19870073"},{"key":"S0007114596001341_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.2.254"},{"key":"S0007114596001341_ref025","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19930149"},{"key":"S0007114596001341_ref041","first-page":"12","article-title":"Rat metabolism cage","volume":"21","author":"Thompson","year":"1970","journal-title":"Journal of the Institute of Animal Technicians"},{"key":"S0007114596001341_ref004","first-page":"366","volume-title":"Digestion and Metabolism in the Ruminant","author":"Demeyer","year":"1975"},{"key":"S0007114596001341_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.4.906"},{"key":"S0007114596001341_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.Suppl.221"},{"key":"S0007114596001341_ref008","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1989.sp003291"},{"key":"S0007114596001341_ref009","first-page":"212\/1","volume-title":"Techniques in Life Sciences. Digestive Physiology","author":"Goodlad","year":"1982"},{"key":"S0007114596001341_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945355"},{"key":"S0007114596001341_ref011","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1242\/jcs.107.12.3569","article-title":"Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis","volume":"107","author":"Hall","year":"1994","journal-title":"Journal of Cell Science"},{"key":"S0007114596001341_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/47.6.1004"},{"key":"S0007114596001341_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(88)80068-4"},{"key":"S0007114596001341_ref015","unstructured":"Key F. B. (1990). Digestion and large bowel fermentation of breads and haricot beans (Phaseolus vulgaris). PhD Thesis, University of Newcastle upon Tyne."},{"key":"S0007114596001341_ref020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Fohn phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"S0007114596001341_ref024","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19940128"},{"key":"S0007114596001341_ref026","first-page":"38A","article-title":"Stimulation of large bowel fermentation has no effects on duodenal epithelial proliferation in rats given white bread-based diets","volume":"49","author":"Mathers","year":"1990","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114596001341_ref028","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.3.391"},{"key":"S0007114596001341_ref027","first-page":"376A","article-title":"Factors influencing caecal butyrate in rats fed on raw potato starch","volume":"52","author":"Mathers","year":"1993","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114596001341_ref031","first-page":"7415","article-title":"Increased cell division as a cause of human cancer","volume":"50","author":"Preston-Martin","year":"1990","journal-title":"Cancer Research"},{"key":"S0007114596001341_ref032","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/119.4.560"},{"key":"S0007114596001341_ref033","first-page":"401","volume-title":"Physiological and Clinical Aspects of Short-chain Fatty Acids","author":"Rombeau","year":"1995"},{"key":"S0007114596001341_ref035","doi-asserted-by":"publisher","DOI":"10.3109\/00365528809090191"},{"key":"S0007114596001341_ref036","first-page":"289","volume-title":"physiological and Clinical Aspects of Short-chain Fatty Acids","author":"Sakata","year":"1995"},{"key":"S0007114596001341_ref038","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19890015"},{"key":"S0007114596001341_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(67)90237-6"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114596001341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T17:23:03Z","timestamp":1626024183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114596001341\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["S0007114596001341"],"URL":"https:\/\/doi.org\/10.1079\/bjn19960031","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}