{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:31:44Z","timestamp":1767155504890,"version":"build-2238731810"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":4054,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:sec id=\"S0007114596000335_seco1\">\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>The impaired absorption and metabolism of Fe seen in riboflavin defiaency is attributed, at least in part, to a hyperproliferative response in the small intestine, associated with an altered morphology. Studies were conducted in female weanling Wistar rats to explore further the effect of riboflavin deficiency on the cytokinetics and structure of the small intestine. Feeding a riboflavin-deficient diet for 8 weeks from weaning resulted in a significantly lower villus number, a significant increase in villus length and an increased rate of transit of enterocytes along the villi, compared with weight-matched controls. A second experiment focused on the 3 weeks after weaning and showed that riboflavin deficiency inhibits the increase in villus number observed in control animals over this period. We suggest that riboflavin deficiency induced at weaning impairs the normal increase in villus number and that prolonged deficiency leads to an adaptive increase in length of villi and depth of crypts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1079\/bjn19960133","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:09:04Z","timestamp":1118498944000},"page":"315-324","source":"Crossref","is-referenced-by-count":26,"title":["Cytokinetic and structural responses of the rat small intestine to riboflavin depletion"],"prefix":"10.1017","volume":"75","author":[{"given":"E. A.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D. E.","family":"Rumsey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114596000335_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90412-2"},{"key":"S0007114596000335_ref011","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19930055"},{"key":"S0007114596000335_ref008","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/9780470110324.ch5","volume-title":"Methods of Biochemical Analysis","volume":"5","author":"Munro","year":"1966"},{"key":"S0007114596000335_ref012","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910107"},{"key":"S0007114596000335_ref016","doi-asserted-by":"publisher","DOI":"10.2307\/3571434"},{"key":"S0007114596000335_ref003","first-page":"53","article-title":"Small bowel adaptation and its regulation","volume":"74","author":"Dowling","year":"1982","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"S0007114596000335_ref013","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19880047"},{"key":"S0007114596000335_ref007","doi-asserted-by":"publisher","DOI":"10.1126\/science.7123245"},{"key":"S0007114596000335_ref002","first-page":"27","article-title":"The effect of growth and fasting on the number of villi and crypts in the small intestine of the albino rat","volume":"112","author":"Clarke","year":"1972","journal-title":"Journal of Anatomy"},{"key":"S0007114596000335_ref010","first-page":"371","article-title":"Effects of riboflavin deficiency on some aspects of iron metabolism","volume":"53","author":"Powers","year":"1983","journal-title":"International Journal for Vitamin and Nutrition Research"},{"key":"S0007114596000335_ref017","first-page":"179","article-title":"Use of bromodeoxyuridine for cell kinetic studies in intact animals","volume":"19","author":"Wynford-Thomas","year":"1986","journal-title":"Cell Tissue Kinetics"},{"key":"S0007114596000335_ref004","doi-asserted-by":"publisher","DOI":"10.1159\/000177696"},{"key":"S0007114596000335_ref005","first-page":"283","article-title":"The number of villi in the rat's jejunum and ileum: effect of normal growth, partial enterectomy and tube feeding","volume":"111","author":"Forrester","year":"1972","journal-title":"Journal of Anatomy"},{"key":"S0007114596000335_ref014","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19950015"},{"key":"S0007114596000335_ref006","first-page":"109","article-title":"Changes in intestinal cell proliferation, absorptive capacity and structure in young, adult and old rats","volume":"173","author":"Goodlad","year":"1990","journal-title":"Journal of Anatomy"},{"key":"S0007114596000335_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.5.852"},{"key":"S0007114596000335_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)56696-5"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114596000335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T10:44:29Z","timestamp":1706265869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114596000335\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":17,"aliases":["10.1017\/bjn19960133"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["S0007114596000335"],"URL":"https:\/\/doi.org\/10.1079\/bjn19960133","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}