{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:35:49Z","timestamp":1791178549156,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":3994,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>Studies with anaemic children and pregnant women from areas where vitamin A deficiency is endemic have shown a beneficial effect on Fe status of supplemental vitamin A in addition to Fe supplementation. This suggests a relationship between vitamin Aand Fe status, which we attempted to mimic in rats with anaemia and chronic vitaminA deficiency. Male rats were fed on Fe-adequate diets (35 mg Fe\/kg)containing different levels of vitamin A (1200,450,150,75 and 0 retinol equivalents (RE)\/kg feed) until they were 5 weeks old. These diets wereidentical to the diets fed to their mothers. Then the young male rats were transferred to diets containing the same levels of vitamin A but no added Fe. After another 2 weeks the rats wererepleted with Fe (35 mg\/kg feed) without or with vitamin A to a level of 1200 RE\/kg feed. Increased vitamin A intake by the groups previously fed on diets with either 0 or 75 RE\/kg produced a reduction in blood haemoglobin concentration, packed cell volume and erythrocyte count. In the group which had been fed on the diet without vitamin A, supplemental vitamin A raised mean cell volume, plasma Fe concentration and total Fe-binding capacity. Vitamin A supplementation during the period of Fe repletion produceda decrease in splenic and tibia Fe concentration, the effect being greater with increasing seventy of previous vitamin A deficiency. The paradoxical effect of supplemental vitamin A on haemoglobin, packed cell volume and erythrocyte count can be explained by a decrease in the degree of haemwoncentration. Thus, the positive effect of supplemental vitamin A seen in humans is also observed with rats under controlled experimental conditions. We speculate that supplemental vitamin A during Fe repletion contributes to optimum erythropoiesis and Fe mobilization when baseline vitamin A status is impaired<\/jats:p>","DOI":"10.1079\/bjn19960165","type":"journal-article","created":{"date-parts":[[2005,9,17]],"date-time":"2005-09-17T00:07:20Z","timestamp":1126915640000},"page":"623-636","source":"Crossref","is-referenced-by-count":48,"title":["Supplemental vitamin A enhances the recovery from iron deficiency in rats with chronic vitamin A deficiency"],"prefix":"10.1017","volume":"75","author":[{"given":"AnnetJ.C","family":"Roodenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive E","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hovenierl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton 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