{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:21:16Z","timestamp":1694632876093},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":2227,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>Whole-blood free amino acids were measured in a control group made up of eight healthy women fasted for 12 h and also in eight patients with acute pancreatitis, five patients with acute cholecystitis and seven patients with acute appendicitis. Blood was withdrawn immediately on admission to hospital and again 3 d later following a controlled peripheral parenteral nutrition diet; this is with the exception of the appendicitis group. L-CYSTATHIONINE AND l-methionine concentrations were significantly higher in pancreatitis and appendicitis patients when compared with controls. In the pancreatitis and cholecystitis patients, l-serine concentration was also significantly higher when compared with controls. The l-homocysteine concentration was significantly higher only in the appendicitis group when compared with the control group. l-Cystine concentration was unchanged in all the patients studied when compared with control subjects. The l-methionine : l-cystine ratio was significantly higher and the l-glutamine : l-cystine ratio was significantly lower in all the patients when compared with controls. The blood S-amino acid pattern reflects an impairment in liver transsulfuration pathway during acute abdominal processes. This work supports the idea that the l-methionine : l-cystine and l-glutamine : l-cystine ratios can be taken as good markers to evaluate the S-amino acid metabolism and suggests the importance of using<jats:italic>N<\/jats:italic>-acetylcysteine as a required nutrient in these situations.<\/jats:p>","DOI":"10.1079\/bjn2000237","type":"journal-article","created":{"date-parts":[[2008,5,15]],"date-time":"2008-05-15T16:07:49Z","timestamp":1210867669000},"page":"173-178","source":"Crossref","is-referenced-by-count":4,"title":["Blood sulfur-amino acid concentration reflects an impairment of liver transsulfuration pathway in patients with acute abdominal inflammatory processes"],"prefix":"10.1017","volume":"85","author":[{"given":"Juan R.","family":"Vi\u00f1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina","family":"Corbacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada R.","family":"Puertes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Borr\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concha","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Barber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,3,9]]},"reference":[{"key":"S0007114501000241_ref018","first-page":"E322","article-title":"Quantitative study in vivo of methionine cycle in humans using [methyl-2H3] and [1\u201313C]-L-methionine","volume":"18","author":"Storch","year":"1988","journal-title":"American Journal of Physiology"},{"key":"S0007114501000241_ref024","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199307000-00001"},{"key":"S0007114501000241_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.5.1067"},{"key":"S0007114501000241_ref022","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19920099"},{"key":"S0007114501000241_ref015","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/59.1.3"},{"key":"S0007114501000241_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.8.837"},{"key":"S0007114501000241_ref020","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a130387"},{"key":"S0007114501000241_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(83)90500-3"},{"key":"S0007114501000241_ref021","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19970198"},{"key":"S0007114501000241_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)92265-Y"},{"key":"S0007114501000241_ref004","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.13.9367343"},{"key":"S0007114501000241_ref002","doi-asserted-by":"publisher","DOI":"10.1080\/01635589709514506"},{"key":"S0007114501000241_ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199611150-00018"},{"key":"S0007114501000241_ref001","doi-asserted-by":"publisher","DOI":"10.1159\/000189298"},{"key":"S0007114501000241_ref007","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19920039"},{"key":"S0007114501000241_ref009","doi-asserted-by":"publisher","DOI":"10.1042\/cs0920297"},{"key":"S0007114501000241_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.1.97"},{"key":"S0007114501000241_ref017","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-10-199805150-00002"},{"key":"S0007114501000241_ref019","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3940.74"},{"key":"S0007114501000241_ref005","doi-asserted-by":"publisher","DOI":"10.1042\/bj2690335"},{"key":"S0007114501000241_ref008","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.1.9034170"},{"key":"S0007114501000241_ref003","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198466010-00011"},{"key":"S0007114501000241_ref025","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198201001-00013"},{"key":"S0007114501000241_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(90)90070-2"},{"key":"S0007114501000241_ref014","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0021-9258(18)70476-6","article-title":"A crystalline enzyme that cleaves homoserine and cystathionine. 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